All Outputs (156)

Guidance in an uncertain world (2020)
Journal Article
Moppett, I. K., Gardiner, D., & Harvey, D. J. R. (2020). Guidance in an uncertain world. British Journal of Anaesthesia, 125(1), 7-9. https://doi.org/10.1016/j.bja.2020.04.003

In the face of the coronavirus pandemic, clinicians are looking to multiple sources for guidance. Good guidance provides a helpful tool to support decision making by experienced and highly-trained healthcare professionals. However, in the context of... Read More about Guidance in an uncertain world.

Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing (2020)
Journal Article
Autio, J. A., Glasser, M. F., Ose, T., Donahue, C. J., Bastiani, M., Ohno, M., Kawabata, Y., Urushibata, Y., Murata, K., Nishigori, K., Yamaguchi, M., Hori, Y., Yoshida, A., Go, Y., Coalson, T. S., Jbabdi, S., Sotiropoulos, S. N., Kennedy, H., Smith, S., Van Essen, D. C., & Hayashi, T. (2020). Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing. NeuroImage, 215, Article 116800. https://doi.org/10.1016/j.neuroimage.2020.116800

© 2020 The Author(s) Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization of primates including humans. However, the tools and methods for noninvasive image acquis... Read More about Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing.

The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells (2020)
Journal Article
Ruiter, F. A., Sidney, L. E., Kiick, K. L., Segal, J. I., Alexander, C., & Rose, F. R. A. J. (2020). The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells. Biomaterials Science, 8(9), 2611-2626. https://doi.org/10.1039/c9bm01965k

Current cell expansion methods for tissue engineering and regenerative medicine applications rely on the use of enzymatic digestion passaging and 2D platforms. However, this enzymatic treatment significantly reduces cell quality, due to the destructi... Read More about The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells.

Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial) (2020)
Journal Article
Haines, R., White, J., Meakin, G., Tan, W., Hepburn, T., Leighton, P., Hall, D., & Sereda, M. (2020). Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial). Pilot and Feasibility Studies, 6, Article 41. https://doi.org/10.1186/s40814-020-00582-5

Background: The most common management strategy for tinnitus provided in UK audiology clinics is education and advice. This may also be combined with some form of sound therapy (e.g. digital hearing aids). While education and advice is generally prov... Read More about Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial).

An evaluation of paediatric tinnitus services in UK National Health Service audiology departments (2020)
Journal Article
Smith, H., Fackrell, K., Kennedy, V., Barry, J. G., Broomhead, E., & Hoare, D. J. (2020). An evaluation of paediatric tinnitus services in UK National Health Service audiology departments. BMC Health Services Research, 20(1), Article 214. https://doi.org/10.1186/s12913-020-5040-y

© 2020 The Author(s). Background: Whilst evidence indicates many children experience troublesome tinnitus, specialist services for children are far less established than those available for adults. To date, there is limited understanding of how paedi... Read More about An evaluation of paediatric tinnitus services in UK National Health Service audiology departments.

A process for prioritising systematic reviews in tinnitus (2020)
Journal Article
Sereda, M., McFerran, D., Axon, E., Baguley, D. M., Hall, D. A., Potgieter, I., Cima, R., Cox, S., & Hoare, D. J. (2020). A process for prioritising systematic reviews in tinnitus. International Journal of Audiology, 59(8), 640-646. https://doi.org/10.1080/14992027.2020.1733677

© 2020 British Society of Audiology, International Society of Audiology, and Nordic Audiological Society. Objective: To develop an innovative prioritisation process to identify topics for new or updated systematic reviews of tinnitus research. Design... Read More about A process for prioritising systematic reviews in tinnitus.

Readability assessment of self-report hyperacusis questionnaires (2020)
Journal Article
Margol-Gromada, M., Sereda, M., & Baguley, D. M. (2020). Readability assessment of self-report hyperacusis questionnaires. International Journal of Audiology, 59(7), 506-512. https://doi.org/10.1080/14992027.2020.1723033

Objective: To assess the overall readability of five currently available hyperacusis questionnaires and to assess the variability of single items within each questionnaire. Design: Comparative study of self-report hyperacusis questionnaires: (1) Gerä... Read More about Readability assessment of self-report hyperacusis questionnaires.

Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey (2020)
Journal Article
Katiri, R., Hall, D. A., Buggy, N., Hogan, N., Horobin, A., van de Heyning, P., Firszt, J. B., Bruce, I. A., & Kitterick, P. T. (2020). Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey. Trials, 21(1), Article 238. https://doi.org/10.1186/s13063-020-4094-9

Background

Single-sided deafness (SSD) describes the presence of a unilateral severe to profound sensorineural hearing loss. SSD disrupts spatial hearing and understanding speech in background noise. It has functional, psychological and social con... Read More about Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey.

The aetiology of Spaceflight‐Associated Neuro‐ocular Syndrome (SANS) might be explained by a neural mechanism regulating intraocular pressure (2020)
Journal Article
Mekjavic, P. J., Amoaku, W., Mlinar, T., & Mekjavic, I. B. (2020). The aetiology of Spaceflight‐Associated Neuro‐ocular Syndrome (SANS) might be explained by a neural mechanism regulating intraocular pressure. Journal of Physiology, 598(8), 1431-1432. https://doi.org/10.1113/jp279699

Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification (2020)
Journal Article
Godolphin, P. J., Bath, P. M., Partlett, C., Berge, E., Brown, M. M., Eliasziw, M., Sandset, P. M., Serena, J., & Montgomery, A. A. (2020). Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification. European Stroke Journal, 5(2), 174-183. https://doi.org/10.1177/2396987320910047

Neuropsychological outcomes of children with Optic Pathway Glioma (2020)
Journal Article
Papini, C., Dineen, R. A., Walker, D. A., Thomas, S., & Pitchford, N. J. (2020). Neuropsychological outcomes of children with Optic Pathway Glioma. Scientific Reports, 10(1), Article 3344. https://doi.org/10.1038/s41598-020-59896-2

Optic Pathway Glioma (OPG) is a relatively common brain tumour in childhood; however, there is scarce understanding of neuropsychological sequelae in these survivors. In this study, 12 children with diagnosis of OPG before 6 years of age received a c... Read More about Neuropsychological outcomes of children with Optic Pathway Glioma.

Calcium buffers and L-type calcium channels as modulators of cardiac subcellular alternans (2020)
Journal Article
Lai, Y. M., Coombes, S., & Thul, R. (2020). Calcium buffers and L-type calcium channels as modulators of cardiac subcellular alternans. Communications in Nonlinear Science and Numerical Simulation, 85, Article 105181. https://doi.org/10.1016/j.cnsns.2020.105181

In cardiac myocytes, calcium cycling links the dynamics of the membrane potential to the activation of the contractile filaments. Perturbations of the calcium signalling toolkit have been demonstrated to disrupt this connection and lead to numerous p... Read More about Calcium buffers and L-type calcium channels as modulators of cardiac subcellular alternans.

Graph Theoretic Analysis of Brain Connectomics in Multiple Sclerosis: Reliability and Relationship to Cognition (2020)
Journal Article
Welton, T., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2020). Graph Theoretic Analysis of Brain Connectomics in Multiple Sclerosis: Reliability and Relationship to Cognition. Brain Connectivity, 10(2), 95-104. https://doi.org/10.1089/brain.2019.0717

Research suggests that disruption of brain networks might explain cognitive deficits in multiple sclerosis (MS). The reliability and effectiveness of graph-theoretic network metrics as measures of cognitive performance were tested in 37 people with M... Read More about Graph Theoretic Analysis of Brain Connectomics in Multiple Sclerosis: Reliability and Relationship to Cognition.

Face and content validity analysis of the Speech, Spatial and Qualities of Hearing Scale for Parents (SSQ-P) when used in a clinical service without interviews or week-long observation periods (2020)
Journal Article
Killan, C. F., Baxter, P. D., & Killan, E. C. (2020). Face and content validity analysis of the Speech, Spatial and Qualities of Hearing Scale for Parents (SSQ-P) when used in a clinical service without interviews or week-long observation periods. International Journal of Pediatric Otorhinolaryngology, 133, Article 109964. https://doi.org/10.1016/j.ijporl.2020.109964

Objectives
To assess the face and content validity of the Speech, Spatial and Qualities of Hearing Scale for Parents (SSQ-P) when used in a clinical setting without the recommended interviews and observation periods.

Methods
SSQ-P responses comp... Read More about Face and content validity analysis of the Speech, Spatial and Qualities of Hearing Scale for Parents (SSQ-P) when used in a clinical service without interviews or week-long observation periods.

Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer (2020)
Journal Article
Smith, A. K., Ray, K. J., Larkin, J. R., Craig, M., Smith, S. A., & Chappell, M. A. (2020). Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer. Magnetic Resonance in Medicine, 84(3), 1359-1375. https://doi.org/10.1002/mrm.28212

Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI (2020)
Journal Article
Iwabuchi, S. J., Xing, Y., Cottam, W. J., Drabek, M. M., Tadjibaev, A., Fernandes, G. S., Petersen, K. K., Arendt-Nielsen, L., Graven-Nielsen, T., Valdes, A. M., Zhang, W., Doherty, M., Walsh, D., & Auer, D. P. (2020). Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI. PAIN, 161(6), 1255-1263. https://doi.org/10.1097/j.pain.0000000000001829

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity, for example, in postoperative pain after knee replacement. Other factors such as low mood,... Read More about Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) (2020)
Journal Article
Muir, K. W., Bulters, D., Willmot, M., Sprigg, N., Dixit, A., Ward, N., Tyrrell, P., Majid, A., Dunn, L., Bath, P. M., Howell, J., Stroemer, P., Pollock, K., & Sinden, J. (2020). Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). Journal of Neurology, Neurosurgery and Psychiatry, 91(4), 396-401. https://doi.org/10.1136/jnnp-2019-322515

Background

Human neural stem cell implantation may offer improved recovery from stroke. We investigated the feasibility of intracerebral implantation of the allogeneic human neural stem cell line CTX0E03 in the subacute—chronic recovery phase of... Read More about Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2).

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial (2020)
Journal Article
Macho, O., Borges, F. K., Bhandari, M., Guerra-Farfan, E., Patel, A., Sigamani, A., Umer, M., Tiboni, M. E., Villar-Casares, M. D. M., Tandon, V., Tomas-Hernandez, J., Teixidor-Serra, J., Avram, V. R., Winemaker, M., Ramokgopa, M. T., Szczeklik, W., Landoni, G., Wang, C. Y., Begum, D., Neary, J. D., …Quintas, S. (2020). Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. Lancet, 395(10225), 698-708. https://doi.org/10.1016/s0140-6736%2820%2930058-1

Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals (2020)
Journal Article
Mekjavic, I. B., Amoaku, W., Mlinar, T., & Mekjavic, P. J. (2020). Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals. Experimental Physiology, 105(4), 641-651. https://doi.org/10.1113/ep088236

The present study assessed the effect of 6° head down (establishing the cephalad displacement noted in astronauts in microgravity) prone (simulating the effect on the eye) tilt during rest and exercise (simulating exercise performed by astronauts to... Read More about Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals.

Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine (2020)
Journal Article
Lindsay, W. A., Murphy, M. M., Almghairbi, D. S., & Moppett, I. K. (2020). Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine. Anaesthesia, 75(6), 809-815. https://doi.org/10.1111/anae.14967

The applicability of the results of any clinical trial will depend to a large extent on whether the study population is representative of the population seen in clinical practice. The growing older surgical population presents challenges for peri-ope... Read More about Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine.