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Effects of noise exposure on young adults with normal audiograms I: Electrophysiology (2016)
Journal Article
Prendergast, G., Guest, H., Munro, K. J., Kluk, K., Léger, A., Hall, D. A., …Plack, C. J. (2017). Effects of noise exposure on young adults with normal audiograms I: Electrophysiology. Hearing Research, 344, 68-81. https://doi.org/10.1016/j.heares.2016.10.028

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas... Read More about Effects of noise exposure on young adults with normal audiograms I: Electrophysiology.

Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study (2016)
Journal Article
Dziewas, R., Mistry, S., Hamdy, S., Minnerup, J., Van Der Tweel, I., Schäbitz, W., & Bath, P. M. (2017). Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study. International Journal of Stroke, 12(4), https://doi.org/10.1177/1747493016676618

Rationale: Ongoing dysphagia in stroke patients weaned from mechanical ventilation often requires long-term tracheotomy to protect the airway from aspiration. In a recently reported single-centre pilot study, a significantly larger proportion (75%) o... Read More about Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study.

Have cochlear implant, won’t have to travel: introducing telemedicine to people using cochlear implants (2016)
Journal Article
Cullington, H., Kitterick, P. T., DeBold, L., Weal, M., Clarke, N., Newberry, E., & Aubert, L. (2016). Have cochlear implant, won’t have to travel: introducing telemedicine to people using cochlear implants. American Journal of Audiology, 25, https://doi.org/10.1044/2016_AJA-16-0018

Purpose: This paper describes a planned project to design, implement, and evaluate remote care for adults using cochlear implants and compare their outcomes with those following the standard care pathway.Method: Sixty people with cochlear implants wi... Read More about Have cochlear implant, won’t have to travel: introducing telemedicine to people using cochlear implants.

High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery (2016)
Journal Article
Chikhani, M., Das, A., Haque, M., Wang, W., Bates, D., & Hardman, J. (2016). High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117(5), 650-658. https://doi.org/10.1093/bja/aew314

Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial... Read More about High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery.

Effectiveness of alternative listening devices to conventional hearing aids for adults with hearing loss: a systematic review protocol (2016)
Journal Article
Maidment, D. W., Barker, A., Xia, J., & Ferguson, M. A. (2016). Effectiveness of alternative listening devices to conventional hearing aids for adults with hearing loss: a systematic review protocol. BMJ Open, 6(10), Article e011683. https://doi.org/10.1136/bmjopen-2016-011683

Introduction Hearing loss is a major public health concern, affecting over 11 million people in the UK. While hearing aids are the most common clinical intervention for hearing loss, the majority of people that would benefit from using hearing aids d... Read More about Effectiveness of alternative listening devices to conventional hearing aids for adults with hearing loss: a systematic review protocol.

Tinnitus and sleep difficulties after cochlear implantation (2016)
Journal Article
Pierzycki, R. H., Edmondson-Jones, M., Dawes, P., Munro, K. J., Moore, D. R., & Kitterick, P. T. (in press). Tinnitus and sleep difficulties after cochlear implantation. Ear and Hearing, 37(6), Article e402-e408. https://doi.org/10.1097/AUD.0000000000000341

OBJECTIVES:
To estimate and compare the prevalence of and associations between tinnitus and sleep difficulties in a sample of UK adult cochlear implant users and those identified as potential candidates for cochlear implantation.
DESIGN:
The study... Read More about Tinnitus and sleep difficulties after cochlear implantation.

Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials (2016)
Journal Article
Law, Z. K., Meretoja, A., Engelter, S. T., Christensen, H., Muresan, E.-M., Glad, S. B., …Sprigg, N. (in press). Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials. European Stroke Journal, https://doi.org/10.1177/2396987316676610

Purpose
Haematoma expansion is a devastating complication of intracerebral haemorrhage with no established treatment. Tranexamic acid had been an effective haemostatic agent in reducing post-operative and traumatic bleeding. We review current evide... Read More about Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials.

Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging (2016)
Journal Article
Faas, H., Taylor, A. J., Granwehr, J., Lesbats, C., Krupa, J. L., Six, J. S., …Meersmann, T. (2016). Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging. PLoS ONE, 11(10), e0163704. https://doi.org/10.1371/journal.pone.0163704

© 2016 Taylor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging.

Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex (2016)
Journal Article
Wallace, M. N., Cronin, M. J., Bowtell, R. W., Scott, I., Palmer, A. R., & Gowland, P. A. (2016). Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex. Frontiers in Neuroscience, 10, Article 455. https://doi.org/10.3389/fnins.2016.00455

Functional magnetic resonance imaging (fMRI) studies of the auditory region of the temporal lobe would benefit from the availability of image contrast that allowed direct identification of the primary auditory cortex, as this region cannot be accurat... Read More about Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex.

Internet competency predicts practical hearing aid knowledge and skills in first-time hearing aid users (2016)
Journal Article
Maidment, D. W., Brassington, W., Wharrad, H., & Ferguson, M. A. (2016). Internet competency predicts practical hearing aid knowledge and skills in first-time hearing aid users. American Journal of Audiology, 25(3S), https://doi.org/10.1044/2016_AJA-16-0022

Purpose. The purpose of the study was to assess whether Internet competency predicted practical hearing aid knowledge and handling skills in first-time hearing aid users.

Method. The design was a prospective, randomized controlled trial of a multi... Read More about Internet competency predicts practical hearing aid knowledge and skills in first-time hearing aid users.

Altered whole-brain connectivity in albinism (2016)
Journal Article
Welton, T., Ather, S., Proudlock, F. A., Gottlob, I., & Dineen, R. A. (2017). Altered whole-brain connectivity in albinism. Human Brain Mapping, 38(2), 740-752. https://doi.org/10.1002/hbm.23414

Albinism is a group of congenital disorders of the melanin synthesis pathway. Multiple ocular, white matter and cortical abnormalities occur in albinism, including a greater decussation of nerve fibres at the optic chiasm, foveal hypoplasia and nysta... Read More about Altered whole-brain connectivity in albinism.

Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid (2016)
Journal Article
Sidney, L. E., & Hopkinson, A. (in press). Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid. Journal of Tissue Engineering and Regenerative Medicine, https://doi.org/10.1002/term.2316

Keratocytes of the corneal limbal stroma can derive populations of mesenchymal stem cells (MSC) when expanded in vitro. However, once a corneal MSC (cMSC) phenotype is achieved, regaining the keratocyte phenotype can be challenging, and there is no s... Read More about Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid.

Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization (2016)
Journal Article
Alshuft, H., Condon, L., Dineen, R. A., & Auer, D. P. (in press). Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization. PLoS ONE, 11(9), Article e0161687. https://doi.org/10.1371/journal.pone.0161687

Objective

This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis.

Methods

Whole brain cortical thickness and pressure pain th... Read More about Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization.

Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging (2016)
Journal Article
Allan, T. W., Besle, J., Langers, D. R., Davies, J., Hall, D. A., Palmer, A. R., & Adjamian, P. (2016). Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging. Frontiers in Aging Neuroscience, 8, Article 221. https://doi.org/10.3389/fnagi.2016.00221

Previous studies of anatomical changes associated with tinnitus have provided inconsistent results, with some showing significant cortical and subcortical changes, while others have found effects due to hearing loss, but not tinnitus. In this study,... Read More about Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging.

The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage (2016)
Journal Article
Meng, Q., An, S., Damion, R. A., Jin, Z., Wilcox, R., Fisher, J., & Jones, A. (2017). The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage. Journal of the Mechanical Behavior of Biomedical Materials, 65, 439-453. https://doi.org/10.1016/j.jmbbm.2016.09.001

The highly inhomogeneous distribution of collagen fibrils may have important effects on the biphasic mechanics of articular cartilage. However, the effect of the inhomogeneity of collagen fibrils has mainly been investigated using simplified three-la... Read More about The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage.

Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review (2016)
Journal Article
Vas, V., Akeroyd, M. A., & Hall, D. A. (2016). Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review. BMJ Open, 6(9), 1-6. https://doi.org/10.1136/bmjopen-2016-011463

INTRODUCTION:
Hearing loss is a highly prevalent condition that affects around 1 in 6 people in the UK alone. This number is predicted to rise by the year 2031 to a staggering 14.5 million people due to the ageing population of the UK. Currently, th... Read More about Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review.

Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease (2016)
Journal Article
Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2017). Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease. Radiology, 282(2), 502-515. https://doi.org/10.1148/radiol.2016152685

Purpose: To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD).
Material... Read More about Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease.

Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730) (2016)
Journal Article
Sprigg, N., O’Connor, R., Woodhouse, L. J., Krishnan, K., England, T. J., Connell, L. A., …Bath, P. M. (2016). Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730). PLoS ONE, 11(9), Article e0161359. https://doi.org/10.1371/journal.pone.0161359

Background
Granulocyte-colony stimulating factor (G-CSF) mobilises endogenous haematopoietic stem cells and enhances recovery in experimental stroke. Recovery may also be dependent on an enriched environment and physical activity. G-CSF may have the... Read More about Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730).

Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity (2016)
Journal Article
Li, X., Zhang, Y., Yan, Y., Ciric, B., Ma, C. G., Gran, B., …Zhang, G. X. (2016). Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity. Molecular Therapy, 24(8), 1456-1469. https://doi.org/10.1038/mt.2016.104

© The American Society of Gene and Cell Therapy. Treatment of chronic neurodegenerative diseases such as multiple sclerosis (MS) remains a major challenge. Here we genetically engineer neural stem cells (NSCs) to produce a triply therapeutic cocktail... Read More about Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity.