Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

Chalmers, J.R.; Thomas, K.S.; Apfelbacher, C.; Williams, H.C.; Prinsen, C.A.; Spuls, P.I.; Simpson, E.; Gerbens, L.A.A.; Boers, M.; Barbarot, S.; Stalder, J.F.; Abuabara, K.; Aoki, V.; Ardeleanu, M.; Armstrong, J.; Bang, B.; Berents, T.L.; Burton, T.; Butler, L.; Chubachi, T.; Cresswell-Melville, A.; DeLozier, A.; Eckert, L.; Eichenfield, L.; Flohr, C.; Futamura, M.; Gadkari, A.; Gjerde, E.S.; van Halewijn, K.F.; Hawkes, C.; Howells, L.; Howie, L.; Humphreys, R.; Ishii, H.A.; Kataoka, Y.; Katayama, I.; Kouwenhoven, W.; Langan, S.M.; Leshem, Y.A.; Merhand, S.; Mina-Osorio, P.; Murota, H.; Nakahara, T.; Nunes, F.P.; Nygaard, U.; Nygårdas, M.; Ohya, Y.; Ono, E.; Rehbinder, E.; Rogers, N.K.; Romeijn, G.L.E.; Schuttelaar, M.L.A.; Sears, A.V.; Simpson, M.A.; Singh, J.A.; Srour, J.; Stuart, B.; Svensson, Å.; Talmo, G.; Talmo, H.; Teixeira, H.D.; Thyssen, J.P.; Todd, G.; Torchet, F.; Volke, A.; von Kobyletzki, L.; Weisshaar, E.; Wollenberg, A.; Zaniboni, M.

doi:10.1111/bjd.16543

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial (2018)
Journal Article
Varlet, P., Mackay, A., Burford, A., Molinari, V., Jones, D. T., Izquierdo, E., …Jones, C. (2018). Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. Cancer Cell, 33(5), 829-842.e5. https://doi.org/10.1016/j.ccell.2018.04.004

The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years.... Read More about Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer (2018)
Journal Article
Wilcock, A., Koon, S., Manderson, C., Taylor, V., & Maddocks, M. (2018). Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer. Respiratory Medicine, 140, https://doi.org/10.1016/j.rmed.2018.05.018

Background: Breathlessness is common in patients with thoracic cancer but difficult to manage. The Incremental Shuttle Walking Test (ISWT) can help assess new treatments, but its repeatability has not been described in this group. Aim: To examin... Read More about Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer.

Relapse after treatment withdrawal of antiepileptic drugs for juvenile absence epilepsy and juvenile myoclonic epilepsy (2018)
Journal Article
Healy, L., Moran, M., Singhal, S., O'Donoghue, M. F., Alzoubidi, R., & Whitehouse, W. P. (2018). Relapse after treatment withdrawal of antiepileptic drugs for juvenile absence epilepsy and juvenile myoclonic epilepsy. Seizure - European Journal of Epilepsy, 59, https://doi.org/10.1016/j.seizure.2018.05.015

Purpose Conventional teaching is that juvenile myoclonic epilepsy (JME) and juvenile absence epilepsy (JAE) require lifelong antiepileptic drug (AED) treatment. We therefore wanted to determine how many patients attending our epilepsy service with J... Read More about Relapse after treatment withdrawal of antiepileptic drugs for juvenile absence epilepsy and juvenile myoclonic epilepsy.

Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort (2018)
Journal Article
Schuil, H., Derks, M., Liefers, G.-J., Portielje, J., van de Velde, C., Syed, B., …Bastiaannet, E. (in press). Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2018.05.004

Objective: Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational c... Read More about Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort.

Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol (2018)
Journal Article
Stocks, J., & Valdes, A. M. (2018). Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol. BMJ Open, 8(5), Article e021344. https://doi.org/10.1136/bmjopen-2017-021344

Introduction: The beneficial effect of dietary omega-3 supplementation in younger adults or older people with acute or chronic disease is established. Knowledge is now needed about the effect in medically stable older people. The objective of this st... Read More about Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol.

Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress (2018)
Journal Article
Nwidu, L. L., Oboma, Y. I., Elmorsy, E., & Carter, W. G. (2018). Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress. Journal of Taibah University Medical Sciences, 13(4), https://doi.org/10.1016/j.jtumed.2018.04.006

Objective: Natural antioxidant products are gaining popularity as treatments for various pathological liver injuries. Musanga cecropioides (Urticaceae) leaf extract is used in ethnomedicine for the management of jaundice and other hepatic ailments in... Read More about Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress.

The pattern of penetration and aspiration in acute stroke survivors (2018)
Presentation / Conference Contribution
Everton, L., Benfield, J., Michou, E., Hamdy, S., & Bath, P. M. (2018). The pattern of penetration and aspiration in acute stroke survivors.

Background and Aims: Aspiration is common in acute stroke survivors with dysphagia, is associated with increased pneumonia rates, and is an independent predictor of mortality. However, studies evaluating the nature and pattern of penetration and aspi... Read More about The pattern of penetration and aspiration in acute stroke survivors.

Fulvestrant for the treatment of advanced breast cancer (2018)
Journal Article
Blackburn, S. A., Parks, R. M., & Cheung, K.-L. (2018). Fulvestrant for the treatment of advanced breast cancer. Expert Review of Anticancer Therapy, 18(7), 619-628. https://doi.org/10.1080/14737140.2018.1473038

Introduction: The current issues with endocrine therapy for treatment of advanced breast cancer include balance of efficacy of therapy versus tolerability as well as hormone resistance. The efficacy of fulvestrant, a selective oestrogen receptor degr... Read More about Fulvestrant for the treatment of advanced breast cancer.

A systematic review of the literature describing the outcomes of near-peer mentoring programs for first year medical students (2018)
Journal Article
Akinla, O., Hagan, P., & Atiomo, W. (2018). A systematic review of the literature describing the outcomes of near-peer mentoring programs for first year medical students. BMC Medical Education, 18, Article 98. https://doi.org/10.1186/s12909-018-1195-1

Background Transition into higher education has been identified as one of the most stressful periods for learners. Interventions targeting the transition phase such as near- peer mentoring might help address some of these challenges. We were however... Read More about A systematic review of the literature describing the outcomes of near-peer mentoring programs for first year medical students.

Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study (2018)
Journal Article
Palaniyappan, L., Hodgson, O., Balain, V., Iwabuchi, S., Gowland, P., & Liddle, P. (2019). Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study. Psychological Medicine, 49(3), 412-420. https://doi.org/10.1017/S0033291718001010

Background: In patients with schizophrenia, distributed abnormalities are observed in grey matter volume. A recent hypothesis posits that these distributed changes are indicative of a plastic reorganization process occurring in response to a function... Read More about Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study.

Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness (2018)
Journal Article
Santer, M., Ridd, M. J., Francis, N. A., Stuart, B., Rumsby, K., Chorozoglou, M., …Little, P. (2018). Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness. BMJ, 361, 1-8. https://doi.org/10.1136/bmj.k1332

Objectives: To determine the clinical and cost-effectiveness of including emollient bath additives in the management of childhood eczema. Trial design: Pragmatic randomised open-label superiority trial with two parallel groups. Setting and recrui... Read More about Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness.

Reasons for presenteeism in nurses working in geriatric settings: a qualitative study (2018)
Journal Article
Fiorini, L. A., Griffiths, A., & Houdmont, J. (in press). Reasons for presenteeism in nurses working in geriatric settings: a qualitative study. Journal of Hospital Administration, 7(4), https://doi.org/10.5430/jha.v7n4p9

Objective: To explore the perceived causes of presenteeism in nurses on geriatric wards. Background: Presenteeism, defined as working when unwell, is associated with lost productivity and increased absenteeism. It is more commonly reported by employ... Read More about Reasons for presenteeism in nurses working in geriatric settings: a qualitative study.

Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape (2018)
Journal Article
Kader, T., Hill, P., Rakha, E. A., Campbell, I. G., & Gorringe, K. L. (2018). Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape. Breast Cancer Research, 20, 1-11. https://doi.org/10.1186/s13058-018-0967-1

Background Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportion are upgraded to carcinoma u... Read More about Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape.

Sociodemographic and medical risk factors associated with antepartum depression (2018)
Journal Article
Babu, G. R., Murthy, G. V. S., Singh, N., Nath, A., Rathnaiah, M., Saldanha, N., …Kinra, S. (2018). Sociodemographic and medical risk factors associated with antepartum depression. Frontiers in Public Health, 6, Article 127. https://doi.org/10.3389/fpubh.2018.00127

Background: The increasing recognition of antenatal depression is an emerging area of concern in developing countres. We conducted a study to estimate the prevalence of antenatal mental distress and its relation with sociodemographic factors, obstetr... Read More about Sociodemographic and medical risk factors associated with antepartum depression.

Development of a multimedia educational programme for first-time hearing aid users: a participatory design (2018)
Journal Article
Ferguson, M. A., Leighton, P., Brandreth, M., & Wharrad, H. (in press). Development of a multimedia educational programme for first-time hearing aid users: a participatory design. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1457803

Objective: To develop content for a series of interactive video tutorials (or reusable learning objects, RLOs) for first-time adult hearing aid users, to enhance knowledge of hearing aids and communication. Design: RLO content was based on an elect... Read More about Development of a multimedia educational programme for first-time hearing aid users: a participatory design.

Tumour heterogeneity of breast cancer: from morphology to personalised medicine (2018)
Journal Article
Aleskandarany, M. A., Vandenberghe, M. E., Marchiò, C., Ellis, I. O., Sapino, A., & Rakha, E. A. (2018). Tumour heterogeneity of breast cancer: from morphology to personalised medicine. Pathobiology, 85(1-2), 23-34. https://doi.org/10.1159/000477851

Breast cancer (BC) displays striking clinical, morphological, and behavioural diversity within a single tumour and between tumours. Currently, mounting evidence indicates that the morphological heterogeneity of BC reflects an underlying spectrum of g... Read More about Tumour heterogeneity of breast cancer: from morphology to personalised medicine.

Interventions for preventing occupational irritant hand dermatitis (Review) (2018)
Journal Article
Bauer, A., Rönsch, H., Elsner, P., Dittmar, D., Bennett, C., Schuttelaar, M.-L. A., …Williams, H. C. (in press). Interventions for preventing occupational irritant hand dermatitis (Review). Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD004414.pub3

Background: Occupational irritant hand dermatitis (OIHD) causes significant functional impairment, disruption of work, and discomfort in the working population. Different preventive measures such as protective gloves, barrier creams and moisturisers... Read More about Interventions for preventing occupational irritant hand dermatitis (Review).

A gyral coordinate system predictive of fibre orientations (2018)
Journal Article
Cottaar, M., Bastiani, M., Chen, C., Dikranian, K., Van Essen, D., Behrens, T. E., …Jbabdi, S. (2018). A gyral coordinate system predictive of fibre orientations. NeuroImage, 176, https://doi.org/10.1016/j.neuroimage.2018.04.040

When axonal fibres approach or leave the cortex, their trajectories tend to closely follow the cortical convolutions. To quantify this tendency, we propose a three-dimensional coordinate system based on the gyral geometry. For every voxel in the brai... Read More about A gyral coordinate system predictive of fibre orientations.

Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial (2018)
Journal Article
Cullington, H., Kitterick, P. T., Weal, M., & Margol-Gromada, M. (2018). Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial. BMJ Open, 8(4), Article e019640. https://doi.org/10.1136/bmjopen-2017-019640

Introduction: substantial resources are required to provide lifelong post-operative care to people with cochlear implants. Most patients visit the clinic annually. We introduced a person-centred remote follow-up pathway, giving patients telemedicine... Read More about Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial.

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2018)
Journal Article
Chalmers, J., Thomas, K., Apfelbacher, C., Williams, H., Prinsen, C., Spuls, P., …Zaniboni, M. (2018). Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178(5), e332-e341. https://doi.org/10.1111/bjd.16543

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus... Read More about Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

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