Skip to main content

Research Repository

Advanced Search

All Outputs (213)

Progress, challenges and opportunities for Red Listing (2019)
Journal Article
Bachman, S. P., Field, R., Reader, T., Raimondo, D., Donaldson, J., Schatz, G. E., & Lughadha, E. N. (2019). Progress, challenges and opportunities for Red Listing. Biological Conservation, 234, 45-55. https://doi.org/10.1016/j.biocon.2019.03.002

Despite its recognition as an important global resource for conservation, the International Union for Conservation of Nature's (IUCN) Red List of Threatened Species only provides assessments of extinction risk for a small and biased subset of known b... Read More about Progress, challenges and opportunities for Red Listing.

Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus (2019)
Journal Article
Lowry, R. C., Milner, D. S., Al-Bayati, A. M., Lambert, C., Francis, V. I., Porter, S. L., & Sockett, R. E. (2019). Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus. Scientific Reports, 9(1), 1-15. https://doi.org/10.1038/s41598-019-41263-5

Bdellovibrio bacteriovorus is a predatory deltaproteobacterium that encounters individual Gram-negative prey bacteria with gliding or swimming motility, and then is able to invade such prey cells via type IVa pilus-dependent mechanisms. Movement cont... Read More about Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus.

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a (2019)
Journal Article
Sanzà, P., Evans, R. D., Briggs, D. A., Cantero, M., Montoliu, L., Patel, S., …Hume, A. N. (2019). Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a. Journal of Cell Science, 132(9), 1-8. https://doi.org/10.1242/jcs.212035

Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is imp... Read More about Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

Metabolic Peculiarities of Paracoccidioides brasiliensis Dimorphism as Demonstrated by iTRAQ Labeling Proteomics (2019)
Journal Article
Araújo, D. S., Pereira, M., Portis, I. G., dos Santos Junior, A. D. C. M., Fontes, W., de Sousa, M. V., …Soares, C. M. D. A. (2019). Metabolic Peculiarities of Paracoccidioides brasiliensis Dimorphism as Demonstrated by iTRAQ Labeling Proteomics. Frontiers in Microbiology, 10, 1-12. https://doi.org/10.3389/fmicb.2019.00555

Paracoccidioidomycosis (PCM), a systemic mycosis with a high incidence in Latin America, is caused by thermodimorphic fungi of the Paracoccidioides genus. The contact with host occurs by the inhalation of conidia or mycelial propagules which once rea... Read More about Metabolic Peculiarities of Paracoccidioides brasiliensis Dimorphism as Demonstrated by iTRAQ Labeling Proteomics.

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI (2019)
Journal Article
Li, C., Voos, K. M., Pathak, M., Hall, G., McCrae, K. R., Dreveny, I., …Emsley, J. (2019). Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. Journal of Thrombosis and Haemostasis, 17(5), 759-770. https://doi.org/10.1111/jth.14418

Background Plasma prekallikrein (PK) and factor XI (FXI) are apple domain‐containing serine proteases that when activated to PKa and FXIa cleave substrates kininogen, factor XII, and factor IX, respectively, directing plasma coagulation, bradykinin... Read More about Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation (2019)
Journal Article
Mayer, D., Damberger, F. F., Samarasimhareddy, M., Feldmueller, M., Vuckovic, Z., Flock, T., …Veprintsev, D. B. (2019). Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Nature Communications, 10(1), 1-14. https://doi.org/10.1038/s41467-019-09204-y

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution structural data of arrestins bound to phosphorylated receptor C-termi... Read More about Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.

The Epistasis Project: a multi-cohort study of the effects of BDNF, DBH and SORT1 epistasis on Alzheimer's disease risk (2019)
Journal Article
Belbin, O., Morgan, K., Medway, C., Warden, D., Cortina-Borja, M., van Duijn, C. M., …Lehmann, D. J. (2019). The Epistasis Project: a multi-cohort study of the effects of BDNF, DBH and SORT1 epistasis on Alzheimer's disease risk. Journal of Alzheimer's Disease, 68(4), 1535-1547. https://doi.org/10.3233/JAD-181116

Pre-synaptic secretion of brain-derived neurotrophic factor (BDNF) from noradrenergic neurons may protect the Alzheimer’s disease (AD) brain from amyloid pathology. While the BDNF polymorphism (rs6265) is associated with faster cognitive decline and... Read More about The Epistasis Project: a multi-cohort study of the effects of BDNF, DBH and SORT1 epistasis on Alzheimer's disease risk.

Altered haemodynamics cause aberrations in the epicardium (2019)
Journal Article
Perdios, C., Parnall, M., Pang, K. L., & Loughna, S. (2019). Altered haemodynamics cause aberrations in the epicardium. Journal of Anatomy, 234(6), 800-814. https://doi.org/10.1111/joa.12977

During embryo development, the heart is the first functioning organ. Although quiescent in the adult, the epicardium is essential during development to form a normal four‐chambered heart. Epicardial‐derived cells contribute to the heart as it develop... Read More about Altered haemodynamics cause aberrations in the epicardium.

Halofrax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems (2019)
Journal Article
Haque, R., Paradisi, F., & Allers, T. (2019). Halofrax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems. Applied Microbiology and Biotechnology, 103(9), 3807-3817. https://doi.org/10.1007/s00253-019-09725-y

Enzyme-mediated synthesis of pharmaceutical compounds is a ‘green’ alternative to traditional synthetic chemistry, and microbial engineering opens up the possibility of using whole cells as mini-factories. Whole-cell biocatalysis reduces cost by elim... Read More about Halofrax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems.

Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential (2019)
Journal Article
Raghunathan, D., Radford, P. M., Gell, C., Negus, D., Moore, C., Till, R., …Tyson, J. (2019). Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential. Scientific Reports, 9, 1-16. https://doi.org/10.1038/s41598-019-40223-3

In assessing the potential of predatory bacteria, such as Bdellovibrio bacteriovorus, to become live therapeutic agents against bacterial infections, it is crucial to understand and quantify Bdellovibrio host cell interactions at a molecular level. H... Read More about Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential.

Immunological and pathological effects of electronic cigarettes (2019)
Journal Article
Chen, I. L., Todd, I., & Fairclough, L. C. (2019). Immunological and pathological effects of electronic cigarettes. Basic and Clinical Pharmacology and Toxicology, 125(3), 237-252. https://doi.org/10.1111/bcpt.13225

© 2019 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Electronic cigarettes (E-cigarettes) are cons... Read More about Immunological and pathological effects of electronic cigarettes.

Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach (2019)
Journal Article
Stone, A. J., Harston, G. W. J., Carone, D., Okell, T. W., Kennedy, J., & Blockley, N. P. (2019). Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach. Human Brain Mapping, 40(10), 2853-2866. https://doi.org/10.1002/hbm.24564

Metabolic markers of baseline brain oxygenation and tissue perfusion have an important role to play in the early identification of ischaemic tissue in acute stroke. Although well established MRI techniques exist for mapping brain perfusion, quantitat... Read More about Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach.

De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation (2019)
Journal Article
Ducker, C., Chow, L., Saxton, J., Handwerger, J., McGregor, A., Strahl, T., …Shaw, P. E. (2019). De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation. Nucleic Acids Research, 47(9), 4495-4508. https://doi.org/10.1093/nar/gkz166

ELK-1 is a transcription factor involved in ERK-induced cellular proliferation. Here we show that its transcriptional activity is modulated by ubiquitination at lysine 35 (K35). The level of ubiquitinated ELK-1 rises in mitogen-deprived cells and fal... Read More about De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation.

Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function (2019)
Journal Article
Curry, L., Almukhtar, H., Alahmed, J., Roberts, R., & Smith, P. A. (2019). Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function. Toxicological Sciences, 169(2), 543–552. https://doi.org/10.1093/toxsci/kfz068

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognised “off-targets” for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolaemia, but which is also associated wit... Read More about Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function.

Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function (2019)
Journal Article
Curry, L., Almukhtar, H., Alahmed, J., Roberts, R., & Smith, P. A. (2019). Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function. Toxicological Sciences, 169(2), 543–552. https://doi.org/10.1093/toxsci/kfz068

© The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Toxicology. Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognized "off targets" for certain drugs. Simvastatin is one s... Read More about Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function.

Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET (2019)
Journal Article
Cooper, S. L., Soave, M., Jörg, M., Scammells, P. J., Woolard, J., & Hill, S. J. (2019). Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET. British Journal of Pharmacology, 176(7), 864-878. https://doi.org/10.1111/bph.14575

Background and Purpose: Adenosine is a local mediator that regulates a number of physiological and pathological processes via activation of adenosine A1‐receptors. The activity of adenosine can be regulated at the level of its target receptor via dru... Read More about Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET.

Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article
Brown, A. M., Evans, R. D., Smith, P. A., Rich, L. R., & Ransom, B. R. (2019). Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification. Physiological Reports, 7(5), 1-13. https://doi.org/10.14814/phy2.14007

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More about Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification.

c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs (2019)
Journal Article
Luo, W., Chen, J., Li, L., Ren, X., Cheng, T., Lu, S., …Hanotte, O. (2019). c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs. Cell Death and Differentiation, 26(3), 426-442. https://doi.org/10.1038/s41418-018-0129-0

© 2018, ADMC Associazione Differenziamento e Morte Cellulare. The transcription factor c-Myc is an important regulator of cellular proliferation, differentiation and embryogenesis. While c-Myc can inhibit myoblast differentiation, the underlying mech... Read More about c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs.

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., …Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, 1-13. https://doi.org/10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More about Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.