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Immunological and pathological effects of electronic cigarettes

Chen, I. Ling; Todd, Ian; Fairclough, Lucy C.

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I. Ling Chen

Ian Todd


© 2019 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Electronic cigarettes (E-cigarettes) are considered a preferable alternative to conventional cigarettes due to the lack of combustion and the absence of tobacco-specific toxicants. E-cigarettes have rapidly gained in popularity in recent years amongst both existing smokers and previous non-smokers. However, a growing literature demonstrates that E-cigarettes are not as safe as generally believed. Here, we discuss the immunological, and other, deleterious effects of E-cigarettes on a variety of cell types and host defence mechanisms in humans and in murine models. We review not only the effects of complete E-cigarette liquids, but also each of the main components—nicotine, humectants and flavourings. This MiniReview thus highlights the possible role of E-cigarettes in the pathogenesis of disease and raises awareness of the potential harm that E-cigarettes may cause.


Chen, I. L., Todd, I., & Fairclough, L. C. (2019). Immunological and pathological effects of electronic cigarettes. Basic and Clinical Pharmacology and Toxicology, 125(3), 237-252.

Journal Article Type Article
Acceptance Date Mar 4, 2019
Online Publication Date Mar 12, 2019
Publication Date 2019-09
Deposit Date Mar 8, 2019
Publicly Available Date Jun 10, 2019
Journal Basic and Clinical Pharmacology and Toxicology
Print ISSN 1742-7835
Electronic ISSN 1742-7843
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 125
Issue 3
Pages 237-252
Keywords Toxicology; Pharmacology; General Medicine
Public URL
Publisher URL


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