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Cannabinoids and their actions: An update (2019)
Journal Article
Alexander, S. P., & Molina-Holgado, F. (2019). Cannabinoids and their actions: An update. British Journal of Pharmacology, 176(10), 1359-1360. https://doi.org/10.1111/bph.14627

Linked Articles: This article is part of a themed section on 8th European Workshop on Cannabinoid Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.10/issuetoc.

Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway (2019)
Journal Article
Boardman, R., Pang, V., Malhi, N., Lynch, A. P., Leach, L., Benest, A. V., …Machado, M. J. (2019). Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway. AJP - Heart and Circulatory Physiology, 316(5), H1065-H1075. https://doi.org/10.1152/ajpheart.00610.2018

© 2019 the American Physiological Society. The Notch ligand delta-like ligand 4 (Dll4), upregulated by VEGF, is a key regulator of vessel morphogenesis and function, controlling tip and stalk cell selection during sprouting angiogenesis. Inhibition o... Read More about Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway.

Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird (2019)
Journal Article
Kim, K., Jackson, B. C., Zhang, H., Toews, D. P. L., Taylor, S. A., Greig, E. I., …Burke, T. (2019). Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird. Nature Communications, 10(1), Article 1852. https://doi.org/10.1038/s41467-019-09806-6

Colour polymorphisms play a key role in sexual selection and speciation, yet the mechanisms that generate and maintain them are not fully understood. Here, we use genomic and transcriptomic tools to identify the precise genetic architecture and evolu... Read More about Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird.

Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus (2019)
Journal Article
Taylor, C. H., Young, S., Fenn, J., Lamb, A. L., Lowe, A. E., Poulin, B., …Bradley, J. E. (2019). Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus. Functional Ecology, 33(8), 1425-1435. https://doi.org/10.1111/1365-2435.13354

1. The ability, propensity and need to mount an immune response vary both among individuals and within a single individual over time. 2. A wide array of parameters have been found to influence immune state in carefully controlled experiments, but... Read More about Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus.

Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation (2019)
Journal Article
Negm, O. H., Singh, S., Abduljabbar, W., Hamed, M. R., Radford, P., McDermott, E. M., …Tighe, P. J. (2019). Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation. Clinical and Experimental Immunology, 197(3), 352-360. https://doi.org/10.1111/cei.13306

Tumour necrosis factor receptor‐associated periodic syndrome (TRAPS) is an hereditary autoinflammatory disorder characterised by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, which encod... Read More about Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation.

Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis (2019)
Journal Article
Peterson, M. E., Li, Y., Shanks, H., Mile, R., Nair, H., Kyaw, M. H., & Meningococcal Carriage Group. (2019). Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis. BMJ Open, 9(4), Article e024343. https://doi.org/10.1136/bmjopen-2018-024343

Objective Neisseria meningitidis carriage prevalence has known variation across the lifespan, but it is unclear whether carriage varies among meningococcal capsular groups. Therefore, we aimed to characterise group-specific meningococcal carriage by... Read More about Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis.

Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide (2019)
Journal Article
Norman, R. O., Millat, T., Schatschneider, S., Henstra, A. M., Breitkopf, R., Pander, B., …Hodgman, C. (2019). Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide. Engineering Biology, 3(2), 32-40. https://doi.org/10.1049/enb.2018.5003

Clostridium autoethanogenum is an industrial microbe used for the commercial-scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desi... Read More about Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide.

A retrospective analysis of responsible innovation for low-technology innovation in the Global South (2019)
Journal Article
Hartley, S., McLeod, C., Clifford, M., Jewitt, S., & Ray, C. (2019). A retrospective analysis of responsible innovation for low-technology innovation in the Global South. Journal of Responsible Innovation, 6(2), 143-162. https://doi.org/10.1080/23299460.2019.1575682

The role of low-technology innovation in addressing global challenges is undervalued. Responsible innovation (RI) has the potential to direct low-technology innovation toward global challenges in the Global South, yet this possibility remains largely... Read More about A retrospective analysis of responsible innovation for low-technology innovation in the Global South.

A conserved protein, BcmA, mediates motility, biofilm formation, and host colonisation in Adherent Invasive Escherichia coli (2019)
Other
Cogger-Ward, R., Collins, A., McLean, D., Dehinsilu, J., & Huett, A. (2019). A conserved protein, BcmA, mediates motility, biofilm formation, and host colonisation in Adherent Invasive Escherichia coli

Adherent Invasive Escherichia coli (AIEC) is a non-diarrhoeagenic intestinal E. coli pathotype associated with Crohn’s Disease. AIEC pathogenesis is characterised by biofilm formation, adhesion to and invasion of intestinal epithelial cells, and intr... Read More about A conserved protein, BcmA, mediates motility, biofilm formation, and host colonisation in Adherent Invasive Escherichia coli.

Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum (2019)
Journal Article
Annan, F. J., Al-Sinawi, B., Humphreys, C. M., Norman, R., Winzer, Köpke, M., …Henstra, A. M. (2019). Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum. Applied Microbiology and Biotechnology, 103(11), 4633–4648. https://doi.org/10.1007/s00253-019-09763-6

Clostridium autoethanogenum and Clostridium ljungdahlii are physiologically and genetically very similar strict anaerobic acetogens capable of growth on carbon monoxide as sole carbon source. While exact nutritional requirements have not been reporte... Read More about Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum.

Comparative analysis of the chicken IFITM locus by targeted genome sequencing reveals evolution of the locus and positive selection in IFITM1 and IFITM3 (2019)
Journal Article
Bassano, I., Ong, S. H., Sanz-Hernandez, M., Vinkler, M., Kebede, A., Hanotte, O., …Kellam, P. (2019). Comparative analysis of the chicken IFITM locus by targeted genome sequencing reveals evolution of the locus and positive selection in IFITM1 and IFITM3. BMC Genomics, 20(1), Article 272. https://doi.org/10.1186/s12864-019-5621-5

Background The interferon-induced transmembrane (IFITM) protein family comprises a class of restriction factors widely characterised in humans for their potent antiviral activity. Their biological activity is well documented in several animal spec... Read More about Comparative analysis of the chicken IFITM locus by targeted genome sequencing reveals evolution of the locus and positive selection in IFITM1 and IFITM3.

Complex formation between VEGFR2 and the β2-adrenoceptor (2019)
Journal Article
Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., …Hill, S. J. (2019). Complex formation between VEGFR2 and the β2-adrenoceptor. Cell Chemical Biology, 26(6), 830-841.e9. https://doi.org/10.1016/j.chembiol.2019.02.014

Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma that is caused by a rapid... Read More about Complex formation between VEGFR2 and the β2-adrenoceptor.

Survivin at a glance (2019)
Journal Article
Wheatley, S. P., & Altieri, D. C. (2019). Survivin at a glance. Journal of Cell Science, 132(7), Article jcs223826. https://doi.org/10.1242/jcs.223826

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all can... Read More about Survivin at a glance.

REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain (2019)
Journal Article
Mampay, M., & Sheridan, G. K. (2019). REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain. Frontiers in Neuroendocrinology, 53, Article 100744. https://doi.org/10.1016/j.yfrne.2019.04.001

The transcriptional repressor REST (Repressor Element-1 Silencing Transcription factor)is a key modulator of the neuronal epigenome and targets genes involved in neuronal differentiation, axonal growth, vesicular transport, ion channel conductance an... Read More about REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain.

Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils (2019)
Journal Article
Preite, V., Sailer, C., Syllwasschy, L., Bray, S., Ahmadi, H., Krämer, U., & Yant, L. (2019). Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils. Philosophical Transactions B: Biological Sciences, 374(1777), https://doi.org/10.1098/rstb.2018.0243

© 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of simila... Read More about Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils.

Whole genome duplication potentiates inter-specific hybridisation and niche shifts in Australian burrowing frogs Neobatrachus (2019)
Other
Novikova, P. Y., Brennan, I. G., Booker, W., Mahony, M., Doughty, P., Lemmon, A. R., …Donnellan, S. C. (2019). Whole genome duplication potentiates inter-specific hybridisation and niche shifts in Australian burrowing frogs Neobatrachus

Polyploidy plays an important role in evolution because it can lead to increased genetic complexity and speciation. It also provides an extra copy buffer and increases genetic novelty. While both common and well-studied in plants, polyploidy is rare... Read More about Whole genome duplication potentiates inter-specific hybridisation and niche shifts in Australian burrowing frogs Neobatrachus.

Azospirillum brasilense Az39, a model rhizobacterium with AHL quorum quenching capacity (2019)
Journal Article
Gualpa, J., Lopez, G., Nievas, S., Coniglio, A., Halliday, N., Cámara, M., & Cassán, F. (2019). Azospirillum brasilense Az39, a model rhizobacterium with AHL quorum quenching capacity. Journal of Applied Microbiology, 126(6), 1850-1860. https://doi.org/10.1111/jam.14269

Aims The aim of this research was to analyze the Quorum sensing (QS) and Quorum quenching (QQ) mechanisms based on N‐acyl‐L‐homoserine lactones (AHLs) in A. brasilense Az39, a strain with remarkable capacity to benefit a wide range of crops under... Read More about Azospirillum brasilense Az39, a model rhizobacterium with AHL quorum quenching capacity.

A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor (2019)
Journal Article
Bouzo-Lorenzo, M., Stoddart, L. A., Xia, L., Jerzman, A. P., Heitman, L. H., Briddon, S. J., & Hill, S. J. (2019). A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor. Purinergic Signalling, 15(2), 139–153. https://doi.org/10.1007/s11302-019-09650-9

There is a growing interest in understanding the binding kinetics of compounds that bind to G proteincoupled receptors prior to progressing a lead compound into clinical trials. The widely expressed adenosine A3 receptor (A3AR) has been implicated in... Read More about A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor.

Paternally expressed imprinted genes under positive Darwinian selection in Arabidopsis thaliana (2019)
Journal Article
Tuteja, R., McKeown, P. C., Ryan, P., Morgan, C. C., Donoghue, M. T., Downing, T., …Spillane, C. (2019). Paternally expressed imprinted genes under positive Darwinian selection in Arabidopsis thaliana. Molecular Biology and Evolution, 36(6), 1239–1253. https://doi.org/10.1093/molbev/msz063

Genomic imprinting is an epigenetic phenomenon where autosomal genes display uniparental expression depending on whether they are maternally or paternally inherited. Genomic imprinting can arise from parental conflicts over resource allocation to the... Read More about Paternally expressed imprinted genes under positive Darwinian selection in Arabidopsis thaliana.