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Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide

Norman, Rupert O.J.; Millat, Thomas; Schatschneider, Sarah; Henstra, Anne M.; Breitkopf, Ronja; Pander, Bart; Annan, Florence J.; Piatek, Pawel; Hartman, Hassan B.; Poolman, Mark G.; Fell, David A.; Winzer, Klaus; Minton, Nigel P.; Hodgman, Charlie

Authors

Rupert O.J. Norman

Sarah Schatschneider

Anne M. Henstra

Ronja Breitkopf

Bart Pander

Florence J. Annan

Pawel Piatek

Hassan B. Hartman

Mark G. Poolman

David A. Fell

NIGEL MINTON nigel.minton@nottingham.ac.uk
Professor of Appliedmolecular Microbiology

Charlie Hodgman



Abstract

Clostridium autoethanogenum is an industrial microbe used for the commercial-scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desirable, particularly in the formation of the high-value platform chemicals, such as 2,3-butanediol. A new, experimentally parameterised genome scale model of C. autoethanogenum predicts dramatically increased 2,3-butanediol production under non-carbon-limited conditions when thermodynamic constraints on hydrogen production are considered.

Journal Article Type Article
Publication Date Jun 30, 2019
Journal Engineering Biology
Electronic ISSN 2398-6182
Publisher Institution of Engineering and Technology
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
Pages 32-40
APA6 Citation Norman, R. O., Millat, T., Schatschneider, S., Henstra, A. M., Breitkopf, R., Pander, B., …Hodgman, C. (2019). Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide. Engineering Biology, 3(2), 32-40. https://doi.org/10.1049/enb.2018.5003
DOI https://doi.org/10.1049/enb.2018.5003
Publisher URL https://digital-library.theiet.org/content/journals/10.1049/enb.2018.5003

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