All Outputs (213)

Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable (2019)
Journal Article
McDonald, M. W., Black, S. E., Copland, D. A., Corbett, D., Dijkhuizen, R. M., Farr, T. D., …O’Sullivan, M. J. (2019). Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14(8), 774-782. https://doi.org/10.1177/1747493019873600

© 2019 World Stroke Organization. Cognitive impairment is an important target for rehabilitation as it is common following stroke, is associated with reduced quality of life and interferes with motor and other types of recovery interventions. Cogniti... Read More about Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable.

A complete genome sequence of Cupriavidus necator H16 (DSM 428) (2019)
Journal Article
Little, G. T., Ehsaan, M., Arenas-López, C., Jawed, K., Winzer, K., Kovacs, K., & Minton, N. P. (2019). A complete genome sequence of Cupriavidus necator H16 (DSM 428). Microbiology Resource Announcements, 8(37), 1-2. https://doi.org/10.1128/MRA.00814-19

The hydrogen-utilizing strain Cupriavidus necator H16 (DSM 428) was sequenced using a combination of PacBio and Illumina sequencing. Annotation of this strain reveals 6,543 protein-coding genes, 263 pseudogenes, 64 tRNA genes, and 15 rRNA genes.

Strigolactone synthesis is ancestral in land plants, but canonical strigolactone signalling is a flowering plant innovation (2019)
Journal Article
Walker, C., Siu-Ting, K., Taylor, A., O'Connell, M. J., & Bennett, T. (2019). Strigolactone synthesis is ancestral in land plants, but canonical strigolactone signalling is a flowering plant innovation. BMC Biology, 17, 1-19. https://doi.org/10.1186/s12915-019-0689-6

Background Strigolactones (SLs) are an important class of carotenoid-derived signalling molecule in plants, which function both as exogenous signals in the rhizosphere and as endogenous plant hormones. In flowering plants, SLs are synthesized by a c... Read More about Strigolactone synthesis is ancestral in land plants, but canonical strigolactone signalling is a flowering plant innovation.

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus (2019)
Journal Article
Ansari, M. A., Aranday-Cortes, E., Lc, C., Da Silva Filipe, A., Hin, L. S., Bamford, C. G., …Pedergnana, V. (2019). Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 2019(8), 1-23. https://doi.org/10.7554/eLife.42463

© Ansari et al. Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of other host factors is unclear. Here, we... Read More about Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.

Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21 (2019)
Journal Article
Lisci, C., Lewis, J. E., Daniel, Z. C., Stevenson, T. J., Monnier, C., Marshall, H. J., …Jethwa, P. H. (2019). Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21. PLoS ONE, 14(8), Article e0221517. https://doi.org/10.1371/journal.pone.0221517

TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is the natural a... Read More about Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21.

Eukaryote genes are more likely than prokaryote genes to be composites (2019)
Journal Article
Ou, Y., & McInerney, J. O. (2019). Eukaryote genes are more likely than prokaryote genes to be composites. Genes, 10(9), Article 648. https://doi.org/10.3390/genes10090648

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The formation of new genes by combining parts of existing genes is an important evolutionary process. Remodelled genes, which we call composites, have been investigated in many species, howeve... Read More about Eukaryote genes are more likely than prokaryote genes to be composites.

Impaired Awareness of Hypoglycemia Disrupts Blood Flow to Brain Regions Involved in Arousal and Decision Making in Type 1 Diabetes (2019)
Journal Article
Nwokolo, M., Amiel, S. A., O'Daly, O., Byrne, M. L., Wilson, B. M., Pernet, A., …Choudhary, P. (2019). Impaired Awareness of Hypoglycemia Disrupts Blood Flow to Brain Regions Involved in Arousal and Decision Making in Type 1 Diabetes. Diabetes Care, 42(11), 2127-2135. https://doi.org/10.2337/dc19-0337

© 2019 by the American Diabetes Association. OBJECTIVE: Impaired awareness of hypoglycemia (IAH) affects one-quarter of adults with type 1 diabetes and significantly increases the risk of severe hypoglycemia. Differences in regional brain responses t... Read More about Impaired Awareness of Hypoglycemia Disrupts Blood Flow to Brain Regions Involved in Arousal and Decision Making in Type 1 Diabetes.

No evidence for association of body mass index with salivary amylase gene copy number in the UK 1958 Birth Cohort (2019)
Journal Article
Shwan, N. A. A., & Armour, J. A. L. (2019). No evidence for association of body mass index with salivary amylase gene copy number in the UK 1958 Birth Cohort. Obesity, 27(9), 1533-1538. https://doi.org/10.1002/oby.22565

Objective In a 2014 publication, evidence was presented supporting the association of BMI with the copy number of the salivary amylase 1 (AMY1) gene, with an unprecedented effect size of −0.15 kg/m2 (SE 0.02) per copy of AMY1. Most well‐powered atte... Read More about No evidence for association of body mass index with salivary amylase gene copy number in the UK 1958 Birth Cohort.

Piezo1 regulates calcium oscillations and cytokine release from astrocytes (2019)
Journal Article
Sheridan, G. K., Velasco‐Estevez, M., Dev, K. K., Rolle, S. O., & Mampay, M. (2020). Piezo1 regulates calcium oscillations and cytokine release from astrocytes. Glia, 68(1), 145-160. https://doi.org/10.1002/glia.23709

Astrocytes are important for information processing in the brain and they achieve this by fine‐tuning neuronal communication via continuous uptake and release of biochemical modulators of neurotransmission and synaptic plasticity. Often overlooked ar... Read More about Piezo1 regulates calcium oscillations and cytokine release from astrocytes.

Engineering Geobacillus thermoglucosidasius for direct utilisation of holocellulose from wheat straw (2019)
Journal Article
Bashir, Z., Sheng, L., Anil, A., Lali, A., Minton, N. P., & Zhang, Y. (2019). Engineering Geobacillus thermoglucosidasius for direct utilisation of holocellulose from wheat straw. Biotechnology for Biofuels, 12(1), Article 199. https://doi.org/10.1186/s13068-019-1540-6

Background: A consolidated bioprocessing (CBP), where lignocellulose is converted into the desired product(s) in a single fermentative step without the addition of expensive degradative enzymes, represents the ideal solution of renewable routes to ch... Read More about Engineering Geobacillus thermoglucosidasius for direct utilisation of holocellulose from wheat straw.

Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission (2019)
Journal Article
Zeeshan, M., Ferguson, D. J., Abel, S., Burrrell, A., Rea, E., Brady, D., …Tewari, R. (2019). Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission. Life Science Alliance, 2(4), 1-13. https://doi.org/10.26508/lsa.201900488

Eukaryotic flagella are conserved microtubule-based organelles that drive cell motility. Plasmodium, the causative agent of malaria, has a single flagellate stage: the male gamete in the mosquito. Three rounds of endomitotic division in male gametocy... Read More about Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission.

Gene Fusions derived by transcriptional readthrough are Driven by Segmental Duplication in Human (2019)
Journal Article
Mccartney, A., Hyland, E., Cormican, P., Moran, R., Webb, A., Lee, K., …O'Connell, M. (2019). Gene Fusions derived by transcriptional readthrough are Driven by Segmental Duplication in Human. Genome Biology and Evolution, 11(9), 2678-2690. https://doi.org/10.1093/gbe/evz163

Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail have been associated with no... Read More about Gene Fusions derived by transcriptional readthrough are Driven by Segmental Duplication in Human.

Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans (2019)
Journal Article
Alyami, J., Whitehouse, E., Yakubov, G. E., Pritchard, S. E., Hoad, C. L., Blackshaw, E., …Marciani, L. (2019). Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans. British Journal of Nutrition, https://doi.org/10.1017/S0007114519001880

Whole grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known... Read More about Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans.

A statistical and biological response to an informatics appraisal of healthy aging gene signatures (2019)
Journal Article
Timmons, J. A., Gallagher, I. J., Sood, S., Phillips, B., Crossland, H., Howard, R., …Atherton, P. J. (2019). A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20(1), 1-4. https://doi.org/10.1186/s13059-019-1734-z

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. Read More about A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

Timing is everything – impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction (2019)
Journal Article
Sloan, T. J., Murray, E., Yokoyama, M., Massey, R. C., Chan, W. C., Bonev, B., & Williams, P. (2019). Timing is everything – impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction. Journal of Bacteriology, 201(20), Article e00409-19. https://doi.org/10.1128/jb.00409-19

Mutations in the polymorphic Staphylococcus aureus agr locus responsible for quorum sensing (QS) dependent virulence gene regulation occur frequently during host adaptation. In two genomically closely related S. aureus clinical isolates exhibiting ma... Read More about Timing is everything – impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction.

Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo (2019)
Journal Article
Singh, N., Romero, M., Travanut, A., Monteiro, P., Jordana-Lluch, E., Hardie, K. R., …Alexander, C. (2019). Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo. Biomaterials Science, 10(7), 4099-4111. https://doi.org/10.1039/C9BM00773C

Many debilitating infections result from persistent microbial biofilms that do not respond to conventional antibiotic regimens. A potential method to treat such chronic infections is to combine agents which interfere with bacterial biofilm developmen... Read More about Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo.

The genome-wide impact of cadmium on microRNA and mRNA expression in contrasting Cd responsive wheat genotypes (2019)
Journal Article
Zhou, M., Zheng, S., Liu, R., Lu, L., Zhang, C., Zhang, L., …Wu, Y. (2019). The genome-wide impact of cadmium on microRNA and mRNA expression in contrasting Cd responsive wheat genotypes. BMC Genomics, 20(1), Article 615. https://doi.org/10.1186/s12864-019-5939-z

© 2019 The Author(s). Background: Heavy metal ATPases (HMAs) are responsible for Cd translocation and play a primary role in Cd detoxification in various plant species. However, the characteristics of HMAs and the regulatory mechanisms between HMAs a... Read More about The genome-wide impact of cadmium on microRNA and mRNA expression in contrasting Cd responsive wheat genotypes.

Towards a surrogate system to express human lipid binding TCRs (2019)
Journal Article
Wang, R., Pscheid, R., Ghumra, A., Kan, L. Y. L., Cochrane, S., Fairclough, L., & Alcocer, M. J. C. (2019). Towards a surrogate system to express human lipid binding TCRs. Biotechnology Letters, 41(10), 1095-1104. https://doi.org/10.1007/s10529-019-02713-2

Background Previously we reported that natural nut lipids were necessary for sensitization and that natural killer T cells (NKTs) must play a critical role in the development of food allergic responses. A major bottleneck in further understanding... Read More about Towards a surrogate system to express human lipid binding TCRs.

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole (2019)
Journal Article
Klein Herenbrink, C., Verma, R., Lim, H. D., Kopinathan, A., Keen, A., Shonberg, J., …Lane, J. R. (2019). Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole. ACS Chemical Biology, 14(8), 1780-1792. https://doi.org/10.1021/acschembio.9b00342

Partial agonists of the dopamine D2 receptor (D2R) have been developed to treat the symptoms of schizophrenia without causing the side effects elicited by antagonists. The receptor-ligand interactions that determine the intrinsic efficacy of such dru... Read More about Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages (2019)
Journal Article
Wall, R. J., Zeeshan, M., Katris, N. J., Limenitakis, R., Rea, E., Stock, J., …Tewari, R. (2019). Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages. Cellular Microbiology, 21(10), Article e13082. https://doi.org/10.1111/cmi.13082

The myosin superfamily comprises of actin‐dependent eukaryotic molecular motors important in a variety of cellular functions. Although well studied in many systems, knowledge of their functions in Plasmodium, the causative agent of malaria, is restri... Read More about Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages.