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c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs (2019)
Journal Article
Luo, W., Chen, J., Li, L., Ren, X., Cheng, T., Lu, S., …Hanotte, O. (2019). c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs. Cell Death and Differentiation, 26(3), 426-442. https://doi.org/10.1038/s41418-018-0129-0

© 2018, ADMC Associazione Differenziamento e Morte Cellulare. The transcription factor c-Myc is an important regulator of cellular proliferation, differentiation and embryogenesis. While c-Myc can inhibit myoblast differentiation, the underlying mech... Read More about c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs.

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., …Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, 1-13. https://doi.org/10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More about Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.

Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis (2019)
Journal Article
Davison, A., Jackson, H. J., Murphy, E. W., & Reader, T. (2019). Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis. Heredity, 123(2), 162-175. https://doi.org/10.1038/s41437-019-0189-z

Biologists have long tried to describe and name the different phenotypes that make up the shell polymorphism of the land snail Cepaea nemoralis. Traditionally, the view is that the ground colour of the shell is one of a few major colour classes, eith... Read More about Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis.

The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis. Annals of Surgery, 270(2), 247-246. https://doi.org/10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer.

Summary background data: Although studies have shown that perioperative IMN... Read More about The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations (2019)
Journal Article
Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., …Cho, M. H. (2019). Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations. Nature Genetics, 51(3), 494–505. https://doi.org/10.1038/s41588-018-0342-2

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 control... Read More about Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations.

Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa (2019)
Journal Article
Monnahan, P., Kolář, F., Baduel, P., Sailer, C., Koch, J., Horvath, R., …Yant, L. (2019). Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa. Nature Ecology and Evolution, 3(3), 457-468. https://doi.org/10.1038/s41559-019-0807-4

Ploidy-variable species allow direct inference of the effects of chromosome copy number on fundamental evolutionary processes. While an abundance of theoretical work suggests polyploidy should leave distinct population genomic signatures, empirical d... Read More about Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa.

Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity (2019)
Journal Article
Holmes, J., Fairclough, L., & Todd, I. (2019). Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity. Archives of Dermatological Research, 311(3), 141-162. https://doi.org/10.1007/s00403-019-01890-4

Atopic dermatitis (AD) is a widespread condition that appears to be increasing in prevalence and severity worldwide, yet the underlying mechanisms are not well understood. Recent research has identified various similarities between AD and autoimmune... Read More about Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity.

Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance (2019)
Journal Article
Merat, S. J., Bru, C., van de Berg, D., Molenkamp, R., Tarr, A. W., Koekkoek, S., …Schinkel, J. (2019). Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance. Journal of Hepatology, 71(1), 14-24. https://doi.org/10.1016/j.jhep.2019.02.013

Background & Aims
Understanding immune protection against hepatitis C virus (HCV) infection is necessary for designing an effective vaccine. A number of broadly-reactive, neutralizing antibodies have been isolated from B cells of HCV-infected subjec... Read More about Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance.

Internal embryonic development in a non-copulatory, egg-laying teleost, the three-spined stickleback, Gasterosteus aculeatus (2019)
Journal Article
Dean, L. L., Robertson, S., Mahmud, M., & Maccoll, A. D. C. (2019). Internal embryonic development in a non-copulatory, egg-laying teleost, the three-spined stickleback, Gasterosteus aculeatus. Scientific Reports, 9(1), Article 2395. https://doi.org/10.1038/s41598-019-38584-w

The switch from egg-laying to retaining and giving birth to live young is a major transition in the history of life. Despite its repeated evolution across the fishes, records of intermediate phenotypes are vanishingly rare, with only two known cases... Read More about Internal embryonic development in a non-copulatory, egg-laying teleost, the three-spined stickleback, Gasterosteus aculeatus.

FT modulates genome-wide DNA-binding of the bZIP transcription factor FD (2019)
Journal Article
Collani, S., Neumann, M., Yant, L., & Schmid, M. (2019). FT modulates genome-wide DNA-binding of the bZIP transcription factor FD. Plant Physiology, 180(1), 367-380. https://doi.org/10.1104/pp.18.01505

© 2019, American Society of Plant Biologists. All rights reserved. The transition to flowering is a crucial step in the plant life cycle that is controlled by multiple endogenous and environmental cues, including hormones, sugars, temperature, and ph... Read More about FT modulates genome-wide DNA-binding of the bZIP transcription factor FD.

Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis (2019)
Journal Article
Ramos Gonzalez, D., Aramendia, A. C., & Davison, A. (2019). Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis. Heredity, 123(2), 153-161. https://doi.org/10.1038/s41437-019-0190-6

Although the land snail Cepaea nemoralis is one of the most thoroughly investigated colour polymorphic species, there have been few recent studies on the inheritance of the shell traits. Previously, it has been shown that the shell polymorphism is co... Read More about Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis.

The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes (2019)
Journal Article
Robinson, C. L., Evans, R. D., Sivarasa, K., Ramalho, J. S., Briggs, D. A., & Hume, A. N. (2019). The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes. Molecular Biology of the Cell, 30(6), 731-809. https://doi.org/10.1091/mbc.E18-04-0237

Regulation of organelle transport by the cytoskeleton is fundamental for eukaryotic survival. Cytoskeleton motors are typically modular proteins with conserved motor and diverse cargo binding domains. Motor:cargo interactions are often indirect and m... Read More about The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes.

G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases (2019)
Journal Article
Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L., & Bunnett, N. W. (2019). G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases. Gastroenterology, 156(6), 1600-1616. https://doi.org/10.1053/j.gastro.2019.01.266

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neu... Read More about G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases.

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis (2019)
Journal Article
Savage, A. M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R. B., …Wilkinson, R. N. (2019). tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10, Article 732. https://doi.org/10.1038/s41467-019-08590-7

Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour of endothelial cells (ECs) as they form vascular networks. Vascular endothelial growth factor (VEGF) is essential for angiogenesis and induces downstream sign... Read More about tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis.

Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses (2019)
Journal Article
Irving, W. L., Jalal, P. J., Urbanowicz, R. A., Horncastle, E., Pathak, M., Goddard, C., …Tarr, A. W. (2019). Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses. Journal of Medical Microbiology, 68(4), 642-648. https://doi.org/10.1099/jmm.0.000935

The liver-expressed pattern recognition receptors (PRRs) mannose binding lectin (MBL), ficolin-2 and ficolin-3 contribute to the innate immune response by activating complement. Binding of soluble ficolin-2 to viral pathogens can directly neutralize... Read More about Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses.

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2020). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, 39(1), 304-305. https://doi.org/10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More about The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

CRISPR-Cas9D10A nickase-assisted base editing in the solvent producer Clostridium beijerinckii (2019)
Journal Article
Li, Q., Seys, F. M., Minton, N. P., Yang, J., Jiang, Y., Jiang, W., & Yang, S. (2019). CRISPR-Cas9D10A nickase-assisted base editing in the solvent producer Clostridium beijerinckii. Biotechnology and Bioengineering, 116(6), 1475-1483. https://doi.org/10.1002/bit.26949

Clostridium beijerinckii is a potentially important industrial microorganism as it can synthesize valuable chemicals and fuels from various carbon sources. The establishment of convenient to use, effective gene tools with which the organism can be ra... Read More about CRISPR-Cas9D10A nickase-assisted base editing in the solvent producer Clostridium beijerinckii.

Effect of a long bout versus short bouts of walking on weight loss during a weight loss diet: a randomized trial (2019)
Journal Article
Madjd, A., Taylor, M. A., Delavari, A., Malekzadeh, R., Macdonald, I. A., & Farshchi, H. R. (2019). Effect of a long bout versus short bouts of walking on weight loss during a weight loss diet: a randomized trial. Obesity, 27(4), 551-558. https://doi.org/10.1002/oby.22416

Objective: To evaluate the effect of different daily physical activity (PA) frequencies while maintaining the same daily volume of PA on weight loss, carbohydrate and lipid metabolism, in women with overweight/obesity throughout a 24- week interventi... Read More about Effect of a long bout versus short bouts of walking on weight loss during a weight loss diet: a randomized trial.