Skip to main content

Research Repository

Advanced Search

All Outputs (180)

The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes (2014)
Journal Article
Cable, J. C., Tan, G. D., Alexander, S. P., & O'Sullivan, S. E. (2014). The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. Lipids in Health and Disease, 13(1), Article 43. https://doi.org/10.1186/1476-511X-13-43

Background: Circulating endocannabinoid levels are increased in obesity and diabetes. We have shown that fatty acid amide hydrolase (FAAH, an endocannabinoid hydrolysing enzyme) in subcutaneous adipose tissue positively correlates with BMI in healthy... Read More about The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes.

Accurate position tracking of optically trapped live cells (2014)
Journal Article
McAlinden, N., Glass, D. G., Millington, O. R., & Wright, A. J. (2014). Accurate position tracking of optically trapped live cells. Biomedical Optics Express, 5(4), https://doi.org/10.1364/BOE.5.001026

Optical trapping is a powerful tool in Life Science research and is becoming common place in many microscopy laboratories and facilities. There is a growing need to directly trap the cells of interest rather than introduce beads to the sample that ca... Read More about Accurate position tracking of optically trapped live cells.

SUMOylation proteins in breast cancer (2014)
Journal Article
Alshareeda, A. T., Negm, O. H., Green, A. R., Nolan, C., Tighe, P., Albarakati, N., …Rakha, E. A. (2014). SUMOylation proteins in breast cancer. Breast Cancer Research and Treatment, 144(3), 519-530. https://doi.org/10.1007/s10549-014-2897-7

Small Ubiquitin-like Modifier proteins (or SUMO) modify the function of protein substrates involved in various cellular processes including DNA damage response (DDR). It is becoming apparent that dysregulated SUMO contribute to carcinogenesis by affe... Read More about SUMOylation proteins in breast cancer.

Form and metabolic scaling in colonial animals (2014)
Journal Article
Hartikainen, H., Humphries, S., & Okamura, B. (2014). Form and metabolic scaling in colonial animals. Journal of Experimental Biology, 217(5), 779-786. https://doi.org/10.1242/jeb.093484

Benthic colonial organisms exhibit a wide variation in size and shape and provide excellent model systems for testing the predictions of models that describe the scaling of metabolic rate with organism size. We tested the hypothesis that colony form... Read More about Form and metabolic scaling in colonial animals.

Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection (2014)
Journal Article
Lattimore, S., Irving, W. L., Collins, S., Penman, C., & Ramsay, M. (2014). Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection. Hepatology, 59(4), 1343-1350. https://doi.org/10.1002/hep.26926

The aim of this work was to develop and validate an algorithm to monitor rates of, and response to, treatment of patients infected with hepatitis C virus (HCV) across England using routine laboratory HCV RNA testing data. HCV testing activity between... Read More about Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection.

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action (2014)
Journal Article
Karagöz, G. E., Duarte, A. M., Akoury, E., Ippel, H., Biernat, J., Morán Luengo, T., …Rüdiger, S. G. (2014). Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action. Cell, 156(5), 963-974. https://doi.org/10.1016/j.cell.2014.01.037

Protein folding in the cell relies on the orchestrated action of conserved families of molecular chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding path, yet the molecular basis of this timing is enigmatic, mainly... Read More about Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action.

The past, present and future of neutralizing antibodies for hepatitis C virus (2014)
Journal Article
Ball, J. K., Tarr, A. W., & McKeating, J. A. (2014). The past, present and future of neutralizing antibodies for hepatitis C virus. Antiviral Research, 105(1), 100-111. https://doi.org/10.1016/j.antiviral.2014.02.013

Hepatitis C virus (HCV) is a major cause of liver disease and hepatocellular carcinoma worldwide. HCV establishes a chronic infection in the majority of cases. However, some individuals clear the virus, demonstrating a protective role for the host im... Read More about The past, present and future of neutralizing antibodies for hepatitis C virus.

Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin (2014)
Journal Article
Farr, T. D., Lai, C.-H., Grünstein, D., Orts-Gil, G., Wang, C.-C., Boehm-Sturm, P., …Harms, C. (2014). Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters, 14(4), https://doi.org/10.1021/nl500388h

Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind spec... Read More about Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin.

Observed drug-receptor association rates are governed by membrane affinity: The importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor (2014)
Journal Article
Sykes, D. A., Parry, C., Reilly, J., Wright, P., Fairhurst, R. A., & Charlton, S. J. (2014). Observed drug-receptor association rates are governed by membrane affinity: The importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor. Molecular Pharmacology, 85(4), 608-617. https://doi.org/10.1124/mol.113.090209

Current pharmacological models for determining affinity and kinetics of drugs for membrane receptors assume the interacting molecules are homogeneously distributed in the bulk aqueous phase. The phospholipid membrane can, however, provide a second co... Read More about Observed drug-receptor association rates are governed by membrane affinity: The importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor.

p63 transcriptionally regulates the expression of matrix metallopeptidase 13 (2014)
Journal Article
Celardo, I., Antonov, A., Amelio, I., Annicchiarico-Petruzzelli, M., & Melino, G. (2014). p63 transcriptionally regulates the expression of matrix metallopeptidase 13. Oncotarget, 5(5), 1279-1289. https://doi.org/10.18632/oncotarget.1778

p63 is a transcriptional factor belonging to p53 family of genes. Beside the role in cancer, partially shared with p53 and the other member p73, p63 also plays exclusive roles in development and homeostasis of ectodermal/epidermal-related organs. Her... Read More about p63 transcriptionally regulates the expression of matrix metallopeptidase 13.

T(2)-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS (2014)
Journal Article
Evans, M. C., Serres, . S., Khrapitchev, A. A., Stolp, H. B., Anthony, D. C., Talbot, K., Turner, M. R., & Sibson, N. R. (2014). T(2)-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS. Journal of Cerebral Blood Flow and Metabolism, 34(5), 785-793. https://doi.org/10.1038/jcbfm.2014.19

Neuroinflammation has been identified as a potential therapeutic target in amyotrophic lateral sclerosis (ALS), but relevant biomarkers are needed. The superoxide dismutase (SOD1)G93A transgenic mouse model of ALS offers a unique opportunity to study... Read More about T(2)-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.

The genetics of Alzheimer's disease: putting flesh on the bones (2014)
Journal Article
Medway, C., & Morgan, K. (2014). The genetics of Alzheimer's disease: putting flesh on the bones. Neuropathology and Applied Neurobiology, 40(2), https://doi.org/10.1111/nan.12101

For two decades the search for genes involved in Alzheimer's disease brought little reward; it was not until the advent of genome-wide association studies (GWAS) that genetic associations started to be revealed. Since 2009 increasingly large GWAS hav... Read More about The genetics of Alzheimer's disease: putting flesh on the bones.

Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution (2014)
Journal Article
Brown, R. J., Koutsoudakisu, G., Urbanowicz, R. A., Mirza, D., Ginkel, C., Riebesehl, N., …Ball, J. K. (2014). Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution. Journal of Virology, 88(1), 667-678. https://doi.org/10.1128/JVI.01745-13

Serine is encoded by two divergent codon types, UCN and AGY, which are not interchangeable by a single nucleotide substitution. Switching between codon types therefore occurs via intermediates (threonine or cysteine) or via simultaneous tandem substi... Read More about Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution.

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis (2014)
Journal Article
Treude, F., Kappes, F., Fahrenkamp, D., Müller-Newen, G., Dajas-Bailador, F., Krämer, O. H., …Hartkamp, J. (2014). Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. Oncotarget, 5(10), https://doi.org/10.18632/oncotarget.1634

The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset of human cancers and its down-regulation serves as a mechanism for cancer cell survival following chemotherapy. PAR-4 re-expression selectively causes apoptosi... Read More about Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis.

A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization (2014)
Journal Article
Mahdavi, J., Pirinccioglu, N., Oldfield, N. J., Carlsohn, E., Stoof, J., Aslam, A., …Ala'Aldeen, D. A. (2014). A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization. Open Biology, 4(1), Article 130202. https://doi.org/10.1098/rsob.130202

Campylobacter jejuni is an important cause of human foodborne gastroenteritis; strategies to prevent infection are hampered by a poor understanding of the complex interactions between host and pathogen. Previous work showed that C. jejuni could bind... Read More about A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization.

B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins (2014)
Journal Article

Chronic hepatitis C virus (HCV) infection has been implicated in the induction and maintenance of B-cell lymphomas. The strongest evidence for this derives from clinical observations of tumor regressions upon antiviral treatments. Here we used multip... Read More about B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins.