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Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin

Farr, Tracy D.; Lai, Chian-Hui; Grünstein, Dan; Orts-Gil, Guillermo; Wang, Cheng-Chung; Boehm-Sturm, Philipp; Seeberger, Peter H.; Harms, Christoph

Authors

Tracy D. Farr

Chian-Hui Lai

Dan Grünstein

Guillermo Orts-Gil

Cheng-Chung Wang

Philipp Boehm-Sturm

Peter H. Seeberger

Christoph Harms

Abstract

Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic.

Journal Article Type Article
Publication Date Feb 25, 2014
Journal Nano Letters
Print ISSN 1530-6984
Electronic ISSN 1530-6992
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 14
Issue 4
Institution Citation Farr, T. D., Lai, C., Grünstein, D., Orts-Gil, G., Wang, C., Boehm-Sturm, P., …Harms, C. (2014). Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters, 14(4), doi:10.1021/nl500388h
DOI https://doi.org/10.1021/nl500388h
Keywords Glyco-magnetic nanoparticle; MRI; Stroke; Selection; Nano-medicine
Publisher URL http://dx.doi.org/10.1021/nl500388h
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Nano Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see http://dx.doi.org/10.1021/nl500388h

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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