Skip to main content

Research Repository

Advanced Search

All Outputs (2211)

Assessing Handheld Mobile Laser Scanners for Forest Surveys (2015)
Journal Article
Ryding, J., Williams, E., Smith, M. J., & Eichhorn, M. P. (2015). Assessing Handheld Mobile Laser Scanners for Forest Surveys. Remote Sensing, 7(1), 1095-1111. https://doi.org/10.3390/rs70101095

Abstract: A handheld mobile laser scanning (HMLS) approach to forest inventory surveying allows virtual reconstructions of forest stands and extraction of key structural parameters from beneath the canopy, significantly reducing survey time when comp... Read More about Assessing Handheld Mobile Laser Scanners for Forest Surveys.

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration (2015)
Journal Article
Peretti, D., Bastide, A., Radford, H., Verity, N., Molloy, C., Martin, M. G., …Mallucci, G. R. (2015). RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration. Nature, 518(7538), 236-239. https://doi.org/10.1038/nature14142

In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity1. Reduction in synapse number is a consistent early feature of neurodegenerative diseases2,3, suggesting def... Read More about RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.

Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection (2015)
Journal Article
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H. L., Paszkiewicz, K., …Diggle, S. P. (2015). Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific Reports, 5, Article 7649. https://doi.org/10.1038/srep07649

The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly resistant to multiple antibiotics. Here, we investigate the phenotypic and genotyp... Read More about Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection.

Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer (2015)
Journal Article
Gaspari, A. L., Sica, G. S., Iaculli, E., Fiorani, C., Tema, G., Stolfi, C., …Amelio, I. (2015). Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer. Oncotarget, 6(15), 13402-13415. https://doi.org/10.18632/oncotarget.2830

Recurrence of colorectal cancer (CRC) following a potentially curative resection is a challenging clinical problem. Matrix metalloproteinase-7 (MMP-7) is over-expressed by CRC cells and supposed to play a major role in CRC cell diffusion and metastas... Read More about Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.

Impact of surface chemistry and topography on the function of antigen presenting cells (2015)
Journal Article
Rostam, H. M., Singh, S., Vrana, N. E., Alexander, M. R., & Ghaemmaghami, A. M. (2015). Impact of surface chemistry and topography on the function of antigen presenting cells. Biomaterials Science, 3(3), 424-441. https://doi.org/10.1039/c4bm00375f

Antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs) play a crucial role in orchestrating immune responses against foreign materials. The activation status of APCs can determine the outcome of an immune response following imp... Read More about Impact of surface chemistry and topography on the function of antigen presenting cells.

[18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections (2015)
Journal Article
Mills, B., Awais, R., Luckett, J., Turton, D., Williams, P., Perkins, A., & Hill, P. (2015). [18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections. EJNMMI Research, 5, Article 13. https://doi.org/10.1186/s13550-015-0095-1

Background Management of infection is a major clinical problem. Staphylococcus aureus is a Gram-positive bacterium which colonises approximately one third of the adult human population. Staphylococcal infections can be life-threatening and are frequ... Read More about [18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections.

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging (2014)
Journal Article
Harston, G. W. J., Tee, Y. K., Blockley, N., Okell, T. W., Thandeswaran, S., Shaya, G., …Kennedy, J. (2015). Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain, 138(1), 36-42. https://doi.org/10.1093/brain/awu374

© 2014 The Author. The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imagi... Read More about Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.

'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models (2014)
Journal Article

© 2014 The British Pharmacological Society. Background and Purpose Non-competitive drugs that confer allosteric modulation of orthosteric ligand binding are of increasing interest as therapeutic agents. Sought-after advantages include a ceiling level... Read More about 'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models.

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor (2014)
Journal Article
Wall, R. J., Fernades, A., Rose, M., Bell, D. R., & Mellor, I. R. (2015). Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor. Environment International, 76, 49-56. https://doi.org/10.1016/j.envint.2014.12.002

The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls. Mixed halogenated variants have been recently identified in food at significant levels but full characterisation requires potency data in... Read More about Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

Spatial complementarity and the coexistence of species (2014)
Journal Article
Velázquez, J., Garrahan, J. P., & Eichhorn, M. P. (2014). Spatial complementarity and the coexistence of species. PLoS ONE, 9(12), Article e114979. https://doi.org/10.1371/journal.pone.0114979

© 2014 Velázquez et al. Coexistence of apparently similar species remains an enduring paradox in ecology. Spatial structure has been predicted to enable coexistence even when population-level models predict competitive exclusion if it causes each spe... Read More about Spatial complementarity and the coexistence of species.

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation (2014)
Journal Article
Melino, G., Amelio, I., Mak, T. W., Inoue, S., Knight, R. A., Markert, E. K., & Levine, A. J. (2015). TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proceedings of the National Academy of Sciences, 112(1), 226-231. https://doi.org/10.1073/pnas.1410609111

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.

Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014)
Journal Article
Bossù, P., Tsuang, D. W., Lleò, A., Wallon, D., Todd, S., Dufouil, C., …Holmans, P. (2015). Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 11(6), 658-671. https://doi.org/10.1016/j.jalz.2014.05.1757

© 2015, Elsevier Inc. All rights reserved. Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underly... Read More about Convergent genetic and expression data implicate immunity in Alzheimer's disease.

Contrasting patterns of turnover between plants, pollinators and their interactions (2014)
Journal Article
Norfolk, O., Eichhorn, M. P., & Gilbert, F. S. (2015). Contrasting patterns of turnover between plants, pollinators and their interactions. Diversity and Distributions, 21(4), https://doi.org/10.1111/ddi.12295

Aim: Biogeographers typically assess patterns of diversity across landscapes. As interacting groups often exhibit contrasting trends, this leads to variation in the structure of interaction networks and thereby influences ecosystem processes. Here we... Read More about Contrasting patterns of turnover between plants, pollinators and their interactions.

Migratory bird species benefit from traditional agricultural gardens in arid South Sinai (2014)
Journal Article
Norfolk, O., Power, A., Eichhorn, M. P., & Gilbert, F. (2015). Migratory bird species benefit from traditional agricultural gardens in arid South Sinai. Journal of Arid Environments, 114, 110-115. https://doi.org/10.1016/j.jaridenv.2014.12.004

In temperate and tropical regions agricultural conversion of natural habitat typically has negative impacts upon the diversity and functional complexity of bird communities. In arid environments however, the irrigation associated with agricultural ca... Read More about Migratory bird species benefit from traditional agricultural gardens in arid South Sinai.

Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers (2014)
Journal Article
Ebrahim, N. A., & Leach, L. (2015). Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers. Stem Cells and Development, 24(4), https://doi.org/10.1089/scd.2014.0207

Mesenchymal stem cells from Wharton’s jelly of human umbilical cords (WJ-MSC) are a valuable alternate source of stem cells. Their role in situ and whether they can interact and cross intact endothelial monolayers requires elucidation. The aim of thi... Read More about Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers.