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Cisplatin induced sensory neuropathy is prevented by vascular endothelial growth factor-A (2015)
Journal Article
Vencappa, S., Donaldson, L. F., & Hulse, R. P. (2015). Cisplatin induced sensory neuropathy is prevented by vascular endothelial growth factor-A. American Journal of Translational Research, 7(6),

Increased patient survival is a mark of modern anti-cancer therapy success. Unfortunately treatment side-effects such as neurotoxicity are a major long term concern. Sensory neuropathy is one of the common toxicities that can arise during platinum ba... Read More about Cisplatin induced sensory neuropathy is prevented by vascular endothelial growth factor-A.

A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes (2015)
Journal Article
Devonshire, I. M., Kwok, C., Suvik, A., Haywood, A. R., Cooper, A. H., & Hathway, G. (in press). A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes. European Journal of Neuroscience, 42(1), https://doi.org/10.1111/ejn.12942

The rostral ventromedial medulla (RVM) regulates a range of involuntary behaviours but is most often associated with nociception via the action of pronociceptive ON cells and antinociceptive OFF cells. The phasic responses of ON and OFF cells determi... Read More about A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes.

TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: A novel mechanism of reduced regulatory T cell function in multiple sclerosis (2015)
Journal Article
Nyirenda, M. H., Morandi, E., Vinkemeier, U., Constantin-Teodosiu, D., Drinkwater, S., Mee, M., …Gran, B. (2015). TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: A novel mechanism of reduced regulatory T cell function in multiple sclerosis. Journal of Immunology, 194(12), 5761-5774. https://doi.org/10.4049/jimmunol.1400472

CD4+ CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defec... Read More about TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: A novel mechanism of reduced regulatory T cell function in multiple sclerosis.

Application of BRET to monitor ligand binding to GPCRs (2015)
Journal Article
Stoddart, L. A., Johnstone, E. K., Wheal, A. J., Goulding, J., Robers, M. B., Machleidt, T., …Pfleger, K. D. (in press). Application of BRET to monitor ligand binding to GPCRs. Nature Methods, 12, https://doi.org/10.1038/nmeth.3398

Bioluminescence resonance energy transfer (BRET) is a well-established method for investigating protein-protein interactions. Here we present a BRET approach to monitor ligand binding to G protein–coupled receptors (GPCRs) on the surface of living ce... Read More about Application of BRET to monitor ligand binding to GPCRs.

Close-range photogrammetry enables documentation of environment-induced deformation of architectural heritage (2015)
Journal Article
Sužiedelytė-Visockienė, J., Bagdžiūnaitė, R., Malys, N., & Maliene, V. (2015). Close-range photogrammetry enables documentation of environment-induced deformation of architectural heritage. Environmental Engineering and Management Journal, 14(6),

Deformation, damage and permanent loss of heritage assets due to various physical and environmental factors has always been a major problem. As the availability of funds for conservation and restoration is limited, the digital documentation of herita... Read More about Close-range photogrammetry enables documentation of environment-induced deformation of architectural heritage.

ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis (2015)
Journal Article
Manna, P. T., Gadelha, C., Puttick, A. E., & Field, M. C. (2015). ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis. Journal of Cell Science, 128(11), https://doi.org/10.1242/jcs.167726

Clathrin-mediated endocytosis (CME) is a major route of entry into eukaryotic cells. A core of evolutionarily ancient genes encodes many components of this system but much of our mechanistic understanding of CME is derived from a phylogenetically nar... Read More about ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis.

Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla (2015)
Journal Article
Walker, S. M., Fitzgerald, M., & Hathway, G. J. (2015). Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla. Anesthesiology, 122(6), https://doi.org/10.1097/ALN.0000000000000658

Background: Neonatal pain and injury can alter long-term sensory thresholds. Descending rostroventral medulla (RVM) pathways can inhibit or facilitate spinal nociceptive processing in adulthood. As these pathways undergo significant postnatal maturat... Read More about Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla.

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression (2015)
Journal Article
Melino, G., & Amelio, I. (2015). The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression. Trends in Biochemical Sciences, 40(8), 425-434. https://doi.org/10.1016/j.tibs.2015.04.007

HIFs have long been associated with resistance to therapy, metastasis, and poor survival rates in cancer patients. In parallel, although the tumor-suppressor p53 acts as the first barrier against tumor transformation, its inactivation also appears to... Read More about The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression.

Model Organisms in G Protein–Coupled Receptor Research (2015)
Journal Article
Langenhan, T., Barr, M. M., Bruchas, M. R., Ewer, J., Griffith, L. C., Maiellaro, I., …Monk, K. R. (2015). Model Organisms in G Protein–Coupled Receptor Research. Molecular Pharmacology, 88(3), 596-603. https://doi.org/10.1124/mol.115.098764

The study of G protein–coupled receptors (GPCRs) has benefited greatly from experimental approaches that interrogate their functions in controlled, artificial environments. Working in vitro, GPCR receptorologists discovered the basic biologic mechani... Read More about Model Organisms in G Protein–Coupled Receptor Research.

Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling (2015)
Journal Article

Background Cerebellar parallel fibres release glutamate at both the synaptic active zone and at extrasynaptic sites—a process known as ectopic release. These sites exhibit different short-term and long-term plasticity, the basis of which is incomple... Read More about Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling.

Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics (2015)
Journal Article
Gadelha, C., Zhang, W., Chamberlain, J. W., Chait, B. T., Wickstead, B., & Field, M. C. (2015). Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics. Molecular and Cellular Proteomics, 14(7), https://doi.org/10.1074/mcp.M114.047647

Surface membrane organization and composition is key to cellular function, and membrane proteins serve many essential roles in endocytosis, secretion, and cell recognition. The surface of parasitic organisms, however, is a double-edged sword; this is... Read More about Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics.

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist (2015)
Journal Article
Stoddart, L. A., Vernall, A. J., Briddon, S. J., Kellam, B., & Hill, S. J. (2015). Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98, 68-77. https://doi.org/10.1016/j.neuropharm.2015.04.013

Fluorescence based probes provide a novel way to study the dynamic internalization process of G protein-coupled receptors (GPCRs). Recent advances in the rational design of fluorescent ligands for GPCRs have been used here to generate new fluorescent... Read More about Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.

Characterisation and comparison of temporal release profiles of nitric oxide generating donors (2015)
Journal Article
Bradley, S. A., & Steinert, J. R. (2015). Characterisation and comparison of temporal release profiles of nitric oxide generating donors. Journal of Neuroscience Methods, 245, 116-124. https://doi.org/10.1016/j.jneumeth.2015.02.024

Background Nitric oxide (NO) is a vital signalling molecule in a variety of tissues including the neuronal, vascular and reproductive system. However, its high diffusibility and inactivation make characterisation of nitrergic signalling difficult. T... Read More about Characterisation and comparison of temporal release profiles of nitric oxide generating donors.

Perspective on Multi-Target Antiplatelet Therapies: High Content Phenotypic Screening as an Unbiased Source of Novel Polypharmacological Strategies (2015)
Journal Article
Landre, V., Amelio, I., Barlev, N., Knight, R., Lisitsa, A., Melino, G., & Antonov, A. (2015). Perspective on Multi-Target Antiplatelet Therapies: High Content Phenotypic Screening as an Unbiased Source of Novel Polypharmacological Strategies. Mini-Reviews in Medicinal Chemistry, 15(8), 622-629. https://doi.org/10.2174/1389557515666150219124018

Platelets play an important role in cardiovascular thrombosis as well as in many other pathological conditions such as inflammation, atherosclerosis and cancer. While multi-target strategies to treat complex diseases are gaining considerable attenti... Read More about Perspective on Multi-Target Antiplatelet Therapies: High Content Phenotypic Screening as an Unbiased Source of Novel Polypharmacological Strategies.

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule (2015)
Journal Article
Soh, E. Y.-C., Chhabra, S. R., Halliday, N., Heeb, S., Müller, C., Birmes, F. S., …Williams, P. (2015). Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule. Environmental Microbiology, 17(11), https://doi.org/10.1111/1462-2920.12857

In Pseudomonas aeruginosa, quorum sensing (QS) regulates the production of secondary metabolites, many of which are antimicrobials that impact on polymicrobial community composition. Consequently, quenching QS modulates the environmental impact of P.... Read More about Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule.

Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces (2015)
Journal Article
Hakami, A. R., Ball, J. K., & Tarr, A. W. (2015). Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces. Journal of Virological Methods, 221, 1-8. https://doi.org/10.1016/j.jviromet.2015.04.023

© 2015 Elsevier B.V. Phage-displayed random peptide libraries are widely used for identifying peptide interactions with proteins and other substrates. Selection of peptide ligands involves iterative rounds of affinity enrichment. The binding properti... Read More about Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces.

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems (2015)
Journal Article
Amelio, I., Landré, V., Knight, R. A., Lisitsa, A., Melino, G., & Antonov, A. V. (2015). Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems. Oncotarget, 6(12), 9646-9656. https://doi.org/10.18632/oncotarget.3917

Targeting the ubiquitin–proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and immunological disorders. There have been multiple efforts recently... Read More about Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems.

Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men (2015)
Journal Article
Stephens, F. B., Chee, C., Wall, B. T., Murton, A. J., Shannon, C. E., van Loon, L. J., & Tsintzas, K. (2015). Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men. Diabetes, 64(5), https://doi.org/10.2337/db14-0961

The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The current study investigated the effect of acutely increasing lipid a... Read More about Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men.