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The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults (2016)
Journal Article
Chowdhury, E. A., Richardson, J. D., Holman, G. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016). The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults. American Journal of Clinical Nutrition, 103(3), https://doi.org/10.3945/ajcn.115.122044

Background: The causal nature of associations between breakfast and health remain unclear in obese individuals. Objective: We sought to conduct a randomized controlled trial to examine causal links between breakfast habits and components of energy b... Read More about The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults.

Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis (2016)
Journal Article
Bonthala, V. S., Mayes, S., Moreton, J., Blythe, M. J., Wright, V., May, S., …Twycross, J. (2016). Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis. PLoS ONE, 11(2), Article e0148771. https://doi.org/10.1371/journal.pone.0148771

Bambara groundnut (Vigna subterranea (L.) Verdc.) is an African legume and is a promising underutilized crop with good seed nutritional values. Low temperature stress in a number of African countries at night, such as Botswana, can effect the growth... Read More about Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis.

Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae (2016)
Journal Article
Xu, Z., & Brown, W. (2016). Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae. BMC Biotechnology, 16, Article 13. https://doi.org/10.1186/s12896-016-0241-5

Background: Phage-encoded serine integrases, such as ϕC31 integrase, are widely used for genome engineering but have not been optimized for use in Saccharomyces cerevisiae although this organism is a widely used organism in biotechnology. Results:... Read More about Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae.

Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling (2016)
Journal Article
Lau, J. T., Whelan, F. J., Herath, I., Lee, C. H., Collins, S. M., Bercik, P., & Surette, M. G. (2016). Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling. Genome Medicine, 8(1), Article 72. https://doi.org/10.1186/s13073-016-0327-7

Background The human gut microbiota has been implicated in most aspects of health and disease; however, most of the bacteria in this community are considered unculturable, so studies have relied on molecular-based methods. These methods generally... Read More about Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12 (2016)
Journal Article
Jackson, V. E., Ntalla, I., Sayers, I., Morris, R., Whincup, P., Casas, J.-P., …Wain, L. V. (in press). Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-207876

Background Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants. Objective To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated... Read More about Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Fruit gardens enhance mammal diversity and biomass in a Southeast Asian rainforest (2016)
Journal Article
Moore, J. H., Sittimongkol, S., Campos-Arceiz, A., Sumpah, T., & Eichhorn, M. P. (2016). Fruit gardens enhance mammal diversity and biomass in a Southeast Asian rainforest. Biological Conservation, 194, https://doi.org/10.1016/j.biocon.2015.12.015

Protected areas are frequently inhabited by people and conservation must be integrated with traditional management systems. Cultivation of fruit gardens is a low-impact agroforestry technique which alters the structure and composition of forest stand... Read More about Fruit gardens enhance mammal diversity and biomass in a Southeast Asian rainforest.

Long-term exposure to irinotecan reduces cell migration in glioma cells. (2016)
Journal Article
Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462. https://doi.org/10.1007/s11060-016-2058-4

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local in... Read More about Long-term exposure to irinotecan reduces cell migration in glioma cells..

Asymmetric competition causes multimodal size distributions in spatially structured populations (2016)
Journal Article
Velázquez, J., Allen, R. B., Coomes, D. A., & Eichhorn, M. P. (2016). Asymmetric competition causes multimodal size distributions in spatially structured populations. Proceedings of the Royal Society B: Biological Sciences, 283(1823), 20152404. https://doi.org/10.1098/rspb.2015.2404

Plant sizes within populations often exhibit multimodal distributions, even when all individuals are the same age and have experienced identical conditions. To establish the causes of this, we created an individual-based model simulating the growth o... Read More about Asymmetric competition causes multimodal size distributions in spatially structured populations.

PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism (2016)
Journal Article
Drees, S. L., Li, C., Prasetya, F., Saleem, M., Dreveny, I., Williams, P., …Fetzner, S. (2016). PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism. Journal of Biological Chemistry, 291(13), https://doi.org/10.1074/jbc.M115.708453

Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinolone biosynthetic pathway, the β-ketoacyl-(acyl carrier prot... Read More about PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism.

The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae (2016)
Journal Article
Ziegler, A. B., Augustin, H., Clark, N. L., Berthelot-Grosjean, M., Simonnet, M. M., Steinert, J. R., …Grosjean, Y. (2016). The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae. Scientific Reports, 6(1), Article 19692. https://doi.org/10.1038/srep19692

Changes in synaptic physiology underlie neuronal network plasticity and behavioral phenomena, which are adjusted during development. The Drosophila larval glutamatergic neuromuscular junction (NMJ) represents a powerful synaptic model to investigate... Read More about The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae.

The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite (2016)
Journal Article
Shang, V., O'Sullivan, S., Kendall, D., & Roberts, R. E. (2016). The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite. Pharmacological Research, 105, https://doi.org/10.1016/j.phrs.2016.01.023

Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the lossof barrier function and an elevated sensitivity to environmental insults. An increased release of theendogenous cannabinoid, anandamide in response... Read More about The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite.

Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration (2016)
Journal Article
Merola, A., Murphy, K., Stone, A. J., Germuska, M. A., Griffeth, V. E., Blockley, N. P., …Wise, R. G. (2016). Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration. NeuroImage, 129, 159-174. https://doi.org/10.1016/j.neuroimage.2016.01.021

© 2016 The Authors. Several techniques have been proposed to estimate relative changes in cerebral metabolic rate of oxygen consumption (CMRO2) by exploiting combined BOLD fMRI and cerebral blood flow data in conjunction with hypercapnic or hyperoxic... Read More about Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration.

The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger (2016)
Journal Article
Raulo, R., Archer, D. B., & Kokolski, M. (2016). The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger. AMB Express, 6(5), https://doi.org/10.1186/s13568-016-0177-0

Genes encoding the key transcription factors (TF) XlnR, ClrA and ClrB were deleted from Aspergillus niger and the resulting strains were assessed for growth on glucose and wheat straw, transcription of genes encoding glycosyl hydrolases and saccharif... Read More about The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger.

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications (2016)
Journal Article
Alvarez, M. M., Liu, J. C., Trujillo-de Santiago, G., Cha, B. H., Vishwakarma, A., Ghaemmaghami, A. M., & Khademhosseini, A. (2016). Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications. Journal of Controlled Release, 240, 349-363. https://doi.org/10.1016/j.jconrel.2016.01.026

Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflamma... Read More about Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications.

Do crab spiders perceive Batesian mimicry in hoverflies? (2016)
Journal Article
Morris, R. L., & Reader, T. (2016). Do crab spiders perceive Batesian mimicry in hoverflies?. Behavioral Ecology, 27(3), 920-931. https://doi.org/10.1093/beheco/arv233

© 2015 The Author. Many putative Batesian mimics only approximately resemble their supposed models, and such "imperfect" mimics are readily distinguished from defended species by humans and other vertebrates. One explanation for the existence of impe... Read More about Do crab spiders perceive Batesian mimicry in hoverflies?.

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines (2016)
Journal Article
Noor, D. A. M., Jeyapalan, J. N., Alhazmi, S., Carr, M., Squibb, B., Wallace, C., …Scotting, P. J. (2016). Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines. npj Genomic Medicine, 1(15009), https://doi.org/10.1038/npjgenmed.2015.9

Silencing of genes by DNA methylation is a common phenomenon in many types of cancer. However, the genome wide effect of DNA methylation on gene expression has been analysed in relatively few cancers. Germ cell tumours (GCTs) are a complex group of m... Read More about Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines.

A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations (2016)
Journal Article
Simon, A. B., Dubowitz, D. J., Blockley, N. P., & Buxton, R. B. (2016). A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations. NeuroImage, 129, 198-213. https://doi.org/10.1016/j.neuroimage.2016.01.001

Calibrated blood oxygenation level dependent (BOLD) imaging is a multimodal functional MRI technique designed to estimate changes in cerebral oxygen metabolism from measured changes in cerebral blood flow and the BOLD signal. This technique addresses... Read More about A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations.

Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage and disease-associated organisms (2016)
Journal Article
Oldfield, N. J., Harrison, O. B., Bayliss, C. D., Maiden, M. C., Ala'Aldeen, D. A., & Turner, D. P. (2016). Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage and disease-associated organisms. Journal of Infectious Diseases, 213(11), 1777-1785. https://doi.org/10.1093/infdis/jiw008

Background. Neisseria meningitidis is a frequent colonizer of the human nasopharynx with asymptomatic carriage providing the reservoir for invasive, disease-causing strains. Serogroup Y (MenY) strains are a major cause of meningococcal disease. High... Read More about Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage and disease-associated organisms.