Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia

Alemu, R.; Gelaw, A. M.; Gashu, D.; Tafere, K.; Mossa, A. W.; Bailey, E.H.; Masters, W. A.; Broadley, M. R.; Lark, R. M.

doi:10.1016/j.geoderma.2022.116013

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article
Harris, A. E., Metzler, V. M., Lothion-Roy, J., Varun, D., Woodcock, C. L., Haigh, D. B., …Jeyapalan, J. N. (2022). Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Frontiers in Endocrinology, 13, Article 1006101. https://doi.org/10.3389/fendo.2022.1006101

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer (2022)
Journal Article
Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Metzler, V. M., Persson, J. L., …Mongan, N. P. (2022). The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers, 14(20), Article 5148. https://doi.org/10.3390/cancers14205148

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing... Read More about The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

Semantic Segmentation of Spontaneous Intracerebral Hemorrhage, Intraventricular Hemorrhage, and Associated Edema on CT Images Using Deep Learning (2022)
Journal Article
Kok, Y. E., Pszczolkowski, S., Law, Z. K., Ali, A., Krishnan, K., Bath, P., …French, A. P. (2022). Semantic Segmentation of Spontaneous Intracerebral Hemorrhage, Intraventricular Hemorrhage, and Associated Edema on CT Images Using Deep Learning. Radiology: Artificial Intelligence, 4(6), https://doi.org/10.1148/ryai.220096

This study evaluated deep learning algorithms for semantic segmentation and quantification of intracerebral hemorrhage (ICH), perihematomal edema (PHE), and intraventricular hemorrhage (IVH) on noncontrast CT scans of patients with spontaneous ICH. M... Read More about Semantic Segmentation of Spontaneous Intracerebral Hemorrhage, Intraventricular Hemorrhage, and Associated Edema on CT Images Using Deep Learning.

Bioaccessibility of iron in pearl millet flour contaminated with different soil types (2022)
Journal Article
Muleya, M., Young, S. D., Broadley, M. R., Joy, E. J., Chopera, P., & Bailey, E. H. (2023). Bioaccessibility of iron in pearl millet flour contaminated with different soil types. Food Chemistry, 402, Article 134277. https://doi.org/10.1016/j.foodchem.2022.134277

A controlled in-vitro experiment was conducted to determine the bioaccessibility of extrinsic soil iron in pearl millet contaminated with typical Malawian soils. Pearl millet was contaminated with soils at ratios typically encountered in real life. I... Read More about Bioaccessibility of iron in pearl millet flour contaminated with different soil types.

Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice (2022)
Journal Article
Morgan, H. L., Furse, S., Dias, I. H. K., Shabir, K., Castellanos, M., Khan, I., …Watkins, A. J. (2022). Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice. Communications Biology, 5(1), Article 929. https://doi.org/10.1038/s42003-022-03914-8

The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a m... Read More about Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.

Modeling root loss reveals impacts on nutrient uptake and crop development (2022)
Journal Article
Schäfer, E. D., Owen, M. R., Band, L. R., Farcot, E., Bennett, M. J., & Lynch, J. P. (2022). Modeling root loss reveals impacts on nutrient uptake and crop development. Plant Physiology, 190(4), 2260-2278. https://doi.org/10.1093/plphys/kiac405

Abstract Despite the widespread prevalence of root loss in plants, its effects on crop productivity are not fully understood. While root loss reduces the capacity of plants to take up water and nutrients from the soil, it may provide benefits by decr... Read More about Modeling root loss reveals impacts on nutrient uptake and crop development.

The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration (2022)
Journal Article
Almousa, L. A., Salter, A. M., Castellanos, M., May, S. T., & Langley-Evans, S. C. (2022). The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration. Nutrients, 14(17), Article 3586. https://doi.org/10.3390/nu14173586

Vascular endothelial cells have a critical role in the maintenance of cardiovascular function. Evidence suggests that endothelial function may be compromised under conditions of magnesium deficiency, which increases vulnerability to inflammation. Who... Read More about The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration.

Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat (2022)
Journal Article
Kareem, S. H., Hawkesford, M. J., DeSilva, J., Weerasinghe, M., Wells, D. M., Pound, M. P., …Foulkes, M. J. (2022). Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat. European Journal of Agronomy, 140, Article 126603. https://doi.org/10.1016/j.eja.2022.126603

Root system architecture (RSA) is important in optimizing the use of nitrogen. High-throughput phenotyping techniques may be used to study root system architecture traits under controlled environments. A root phenotyping platform, consisting of germi... Read More about Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat.

Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids (2022)
Journal Article
Fischer, S., Flis, P., Zhao, F.-J., & Salt, D. E. (in press). Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids. Plant Physiology, 190(3), 1715-1730. https://doi.org/10.1093/plphys/kiac360

Whole-genome duplication generates a tetraploid from a diploid. Newly created tetraploids (neo-tetraploids) of Arabidopsis (Arabidopsis thaliana) have elevated leaf potassium (K), compared to their diploid progenitor. Micro-grafting has previously es... Read More about Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids.

Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism (2022)
Journal Article
Wood, J., Abdelrazig, S., Evseev, S., Ortori, C., Castellanos-Uribe, M., May, S. T., …Rahman, R. (2022). Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism. Cancers, 14(16), Article 3873. https://doi.org/10.3390/cancers14163873

Poor outcomes associated with diffuse high-grade gliomas occur in both adults and children, despite substantial progress made in the molecular characterisation of the disease. Targeting the metabolic requirements of cancer cells represents an alterna... Read More about Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism.

Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism (2022)
Journal Article
Fusi, R., Rosignoli, S., Lou, H., Sangiorgi, G., Bovina, R., Pattem, J. K., …Salvi, S. (2022). Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism. Proceedings of the National Academy of Sciences,

Root angle in crops represents a key trait for efficient capture of soil resources. Root angle is determined by competing gravitropic versus anti-gravitropic offset (AGO) mechanisms. Here we report a new root angle regulatory gene termed ENHANCED GRA... Read More about Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism.

Cereal grain mineral micronutrient and soil chemistry data from GeoNutrition surveys in Ethiopia and Malawi (2022)
Other
Kumssa, D. B., Mossa, A. W., Amede, T., Ander, E. L., Bailey, E. H., Botoman, L., …Nalivata, P. C. (2022). Cereal grain mineral micronutrient and soil chemistry data from GeoNutrition surveys in Ethiopia and Malawi

The dataset comprises primary data for the concentration of 29 mineral micronutrients in cereal grains and up to 84 soil chemistry properties from GeoNutrition project surveys in Ethiopia and Malawi. The work provided insights on geospatial variation... Read More about Cereal grain mineral micronutrient and soil chemistry data from GeoNutrition surveys in Ethiopia and Malawi.

Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold (2022)
Journal Article
Band, L. R., Nelissen, H., Preston, S. P., Rymen, B., Prinsen, E., Abd Elgawad, H., & Beemster, G. T. S. (2022). Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold. Proceedings of the National Academy of Sciences, 119(31), Article e2121288119. https://doi.org/10.1073/pnas.2121288119

The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to investigate the establishment of... Read More about Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold.

The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults (2022)
Journal Article
Likoswe, B. H., Lark, R. M., Phuka, J., Maleta, K., Joy, E., & Lowe, N. M. (2022). The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults. Frontiers in Nutrition, 9, Article 890209. https://doi.org/10.3389/fnut.2022.890209

Population-level assessment of zinc deficiency remains a challenge due to the lack of suitable biomarkers. Spot urinary zinc concentration (UZC) has the potential to provide information on population zinc status in large-scale surveys, but there is n... Read More about The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults.

Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms (2022)
Journal Article
Huang, G., Kilic, A., Karady, M., Zhang, J., Mehra, P., Song, X., …Pandey, B. K. (2022). Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms. Proceedings of the National Academy of Sciences, 119(30), Article e2201072119. https://doi.org/10.1073/pnas.2201072119

Soil compaction represents a major agronomic challenge, inhibiting root elongation and impacting crop yields. Roots use ethylene to sense soil compaction as the restricted air space causes this gaseous signal to accumulate around root tips. Ethylene... Read More about Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms.

Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review (2022)
Journal Article
Mutonhodza, B., Joy, E. J., Bailey, E. H., Lark, M. R., Kangara, M. G., Broadley, M. R., …Chopera, P. (2022). Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review. International Journal of Food Science and Technology, 57(10), 6336-6349. https://doi.org/10.1111/ijfs.15979

Selenium (Se) is essential for human health, however, data on population Se status and agriculture-nutrition-health linkages are limited in sub-Saharan Africa (SSA). The scoping review aims to identify linkages between Se in soils/crops, dietary Se i... Read More about Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review.

Assessing the potential of using the Langdon 5D(5B) substitution line for the introgression of Aegilops tauschii into durum wheat (2022)
Journal Article
Othmeni, M., Grewal, S., Walker, J., Yang, C., King, I. P., & King, J. (2022). Assessing the potential of using the Langdon 5D(5B) substitution line for the introgression of Aegilops tauschii into durum wheat. Frontiers in Plant Science, 13, Article 927728. https://doi.org/10.3389/fpls.2022.927728

Aegilops tauschii, the D-genome donor of hexaploid wheat, provides a source of genetic variation that could be used for tetraploid (durum) wheat improvement. In addition to the genes for wheat quality on the D-genome, which differentiate between brea... Read More about Assessing the potential of using the Langdon 5D(5B) substitution line for the introgression of Aegilops tauschii into durum wheat.

Identification of Fusarium Head Blight Resistance in Triticum timopheevii Accessions and Characterization of Wheat-T. timopheevii Introgression Lines for Enhanced Resistance (2022)
Journal Article
Steed, A., King, J., Grewal, S., Yang, C. Y., Clarke, M., Devi, U., King, I. P., & Nicholson, P. (2022). Identification of Fusarium Head Blight Resistance in Triticum timopheevii Accessions and Characterization of Wheat-T. timopheevii Introgression Lines for Enhanced Resistance. Frontiers in Plant Science, 13, Article 943211. https://doi.org/10.3389/fpls.2022.943211

A diverse panel of wheat wild relative species was screened for resistance to Fusarium head blight (FHB) by spray inoculation. The great majority of species and accessions were susceptible or highly susceptible to FHB. Accessions of Triticum timophee... Read More about Identification of Fusarium Head Blight Resistance in Triticum timopheevii Accessions and Characterization of Wheat-T. timopheevii Introgression Lines for Enhanced Resistance.

The botanical education extinction and the fall of plant awareness (2022)
Journal Article
Stroud, S., Fennell, M., Mitchley, J., Lydon, S., Peacock, J., & Bacon, K. L. (2022). The botanical education extinction and the fall of plant awareness. Ecology and Evolution, 12(7), Article e9019. https://doi.org/10.1002/ece3.9019

Civilization is dependent upon plants for survival. Plants permeate our every moment and our relationship with them will dictate how we will manage the threats of climate change and ecological collapse defining the Anthropocene. Yet, despite the sign... Read More about The botanical education extinction and the fall of plant awareness.

Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia (2022)
Journal Article
Alemu, R., Gelaw, A. M., Gashu, D., Tafere, K., Mossa, A. W., Bailey, E., …Lark, R. M. (2022). Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia. Geoderma, 424, Article 116013. https://doi.org/10.1016/j.geoderma.2022.116013

The value of physical archives of soil material from field sampling activities has been widely recognized. If we want to use archive material for new destructive analyses to support a task, such as spatial mapping, then an efficient sub-sampling stra... Read More about Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia.

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