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All Outputs (218)

Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle (2022)
Journal Article
Negussie, E., González-Recio, O., Battagin, M., Bayat, A., Boland, T., de Haas, Y., …Biscarini, F. (2022). Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle. Journal of Dairy Science, 105(6), 5124-5140. https://doi.org/10.3168/jds.2021-20158

Direct measurements of methane (CH4) from individual animals are difficult and expensive. Predictions based on proxies for CH4 are a viable alternative. Most prediction models are based on multiple linear regressions (MLR) and predictor variables tha... Read More about Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle.

In vitro culture of ovine embryos up to early gastrulating stages (2022)
Journal Article
Ramos-Ibeas, P., González-Brusi, L., Used, M. T., Cocero, M. J., Marigorta, P., Alberio, R., & Bermejo-Álvarez, P. (2022). In vitro culture of ovine embryos up to early gastrulating stages. Development, 149(6), Article dev199743. https://doi.org/10.1242/dev.199743

Developmental failures occurring shortly after blastocyst hatching from the zona pellucida constitute a major cause of pregnancy losses in both humans and farm ungulates. The developmental events occurring following hatching in ungulates include the... Read More about In vitro culture of ovine embryos up to early gastrulating stages.

Tig1 regulates proximo-distal identity during salamander limb regeneration (2022)
Journal Article
Oliveira, C. R., Knapp, D., Elewa, A., Gerber, T., Gonzalez Malagon, S. G., Gates, P. B., Walters, H. E., Petzold, A., Arce, H., Cordoba, R. C., Subramanian, E., Chara, O., Tanaka, E. M., Simon, A., & Yun, M. H. (2022). Tig1 regulates proximo-distal identity during salamander limb regeneration. Nature Communications, 13(1), Article 1141. https://doi.org/10.1038/s41467-022-28755-1

Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests that cells in the stump have an awareness of their spatial location, a property termed pos... Read More about Tig1 regulates proximo-distal identity during salamander limb regeneration.

Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency (2022)
Journal Article
Berndt, N., Wolf, C., Fischer, K., Cura Costa, E., Knuschke, P., Zimmermann, N., Schmidt, F., Merkel, M., Chara, O., Lee-Kirsch, M. A., & Günther, C. (2022). Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. Journal of Investigative Dermatology, 142(3), 633-640.e6. https://doi.org/10.1016/j.jid.2021.04.037

The exonuclease TREX1 safeguards the cells against DNA accumulation in the cytosol and thereby prevents innate immune activation and autoimmunity. TREX1 mutations lead to chronic DNA damage and cell-intrinsic IFN-1 response. Associated disease phenot... Read More about Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., …Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens (2022)
Journal Article
Ceccarelli, A. S., Borges, A., & Chara, O. (2022). Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens. Royal Society Open Science, 9(1), Article 211112. https://doi.org/10.1098/rsos.211112

The reaction–diffusion model constitutes one of the most influential mathematical models to study distribution of morphogens in tissues. Despite its widespread use, the effect of finite tissue size on model-predicted spatio-temporal morphogen distrib... Read More about Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial (2022)
Journal Article
Joy, E. J., Kalimbira, A. A., Sturgess, J., Banda, L., Chiutsi-Phiri, G., Manase, H., …Allen, E. (2022). Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial. Frontiers in Nutrition, 8, Article 788096. https://doi.org/10.3389/fnut.2021.788096

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agron... Read More about Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.

Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation (2022)
Journal Article
Wainwright, J., Millar, K. M., & White, G. A. (2022). Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13469

Objectives: To investigate owners’ views around canine nutrition and wellbeing, how these beliefs may differ according to the weight status of the dog and the implications for owner support approaches. Materials and Methods: A researcher-mediated que... Read More about Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation.

Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)
Journal Article
Kinoshita, M., Kobayashi, T., Planells, B., Klisch, D., Spindlow, D., Masaki, H., …Smith, A. (2021). Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species. Development, 148(23), Article dev199901. https://doi.org/10.1242/dev.199901

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em... Read More about Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article
Sargent, C., Ebanks, B., Hardy, I. C., Davies, T. G. E., Chakrabarti, L., & Stöger, R. (2021). Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain. Frontiers in Insect Science, 1, Article 765179. https://doi.org/10.3389/finsc.2021.765179

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells? (2021)
Journal Article
Savage, A. M., Alberio, R., & Johnson, A. D. (2021). Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?. Biology Open, 10(10), Article bio058890. https://doi.org/10.1242/bio.058890

In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of... Read More about Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?.

Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study (2021)
Journal Article
Silvestri, G., Canedo-Ribeiro, C., Serrano-Albal, M., Labrecque, R., Blondin, P., Larmer, S. G., …Griffin, D. K. (2021). Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study. Cells, 10(9), Article 2284. https://doi.org/10.3390/cells10092284

Approximately one million in vitro produced (IVP) cattle embryos are transferred world-wide each year as a way to improve the rates of genetic gain. The most advanced programmes also apply genomic selection at the embryonic stage by SNP genotyping an... Read More about Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study.

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Waite, L., Bonardi, C., Stevenson, C. W., & Cassaday, H. J. (2021). Strain comparisons in inhibitory discrimination learning and novel object recognition procedures. Physiology and Behavior, 240, Article 113557. https://doi.org/10.1016/j.physbeh.2021.113557

Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.

Postembryonic development and aging of the appendicular skeleton in Ambystoma mexicanum (2021)
Journal Article
Riquelme‐Guzmán, C., Schuez, M., Böhm, A., Knapp, D., Edwards‐Jorquera, S., Ceccarelli, A. S., Chara, O., Rauner, M., & Sandoval‐Guzmán, T. (2022). Postembryonic development and aging of the appendicular skeleton in Ambystoma mexicanum. Developmental Dynamics, 251(6), 1015-1034. https://doi.org/10.1002/dvdy.407

Background
The axolotl is a key model to study appendicular regeneration. The limb complexity resembles that of humans in structure and tissue components; however, axolotl limbs develop postembryonically. In this work, we evaluated the postembryonic... Read More about Postembryonic development and aging of the appendicular skeleton in Ambystoma mexicanum.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article
Alberio, R., & Wolf, E. (2021). Nuclear transfer and the development of genetically modified/gene edited livestock. Reproduction, 162(1), F59-F68. https://doi.org/10.1530/REP-21-0078

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article
Alberio, R., & Wolf, E. (2021). Nuclear transfer and the development of genetically modified/gene edited livestock. Reproduction, 162(1), F59-F68. https://doi.org/10.1530/REP-21-0078

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration (2021)
Journal Article
Cura Costa, E., Otsuki, L., Rodrigo Albors, A., Tanaka, E. M., & Chara, O. (2021). Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration. eLife, 10, Article e55665. https://doi.org/10.7554/elife.55665

Axolotls are uniquely able to resolve spinal cord injuries, but little is known about the mechanisms underlying spinal cord regeneration. We previously found that tail amputation leads to reactivation of a developmental-like program in spinal cord ep... Read More about Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.

Conserved features of non-primate bilaminar disc embryos and the germline (2021)
Journal Article
Alberio, R., Kobayashi, T., & Surani, M. A. (2021). Conserved features of non-primate bilaminar disc embryos and the germline. Stem Cell Reports, 16(5), 1078-1092. https://doi.org/10.1016/j.stemcr.2021.03.011

Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar d... Read More about Conserved features of non-primate bilaminar disc embryos and the germline.

In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction (2021)
Journal Article
Warren, W. G., Papagianni, E. P., Stevenson, C. W., & Stubbendorff, C. (2022). In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction. European Journal of Neuroscience, 55(4), 952-970. https://doi.org/10.1111/ejn.15200

Anxiety and trauma-related disorders, such as post-traumatic stress disorder (PTSD), are debilitating mental illnesses with great personal and socioeconomic costs. Examining memory formation and relevant behavioural responding associated with aversiv... Read More about In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction.