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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., Emes, R. D., Harris, D. W., Wattis, J. A., Dryden, I. L., Hodgman, T. C., Brameld, J. M., & Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombin... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

Defining and quantifying the resilience of responses to disturbance: a conceptual and modelling approach from soil science (2016)
Journal Article
Todman, L., Fraser, F., Corstanje, R., Deeks, L., Harris, J., Pawlett, M., …Whitmore, A. (2016). Defining and quantifying the resilience of responses to disturbance: a conceptual and modelling approach from soil science. Scientific Reports, 6(1), Article 28426. https://doi.org/10.1038/srep28426

There are several conceptual definitions of resilience pertaining to environmental systems and, even if resilience is clearly defined in a particular context, it is challenging to quantify. We identify four characteristics of the response of a system... Read More about Defining and quantifying the resilience of responses to disturbance: a conceptual and modelling approach from soil science.

A novel analytical ultracentrifugation based approach to the low resolution structure of gum arabic (2016)
Journal Article
Gillis, R. B., Adams, G. G., Alzahrani, Q., Harding, S. E., & Allen Bush, C. (2016). A novel analytical ultracentrifugation based approach to the low resolution structure of gum arabic. Biopolymers, 105(9), 618-625. https://doi.org/10.1002/bip.22823

Under investigation are the structural properties of gum arabic, an industrially important biopolymer for use as a stabilizer or in drug delivery, using Analytical Ultracentrifugation—a well-established, matrix-free probe for macromolecular size and... Read More about A novel analytical ultracentrifugation based approach to the low resolution structure of gum arabic.

Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions (2016)
Journal Article
Hussain, R., Harding, S. E., Hughes, C. S., Ma, P., Patching, S. G., Edara, S., …Phillips-Jones, M. K. (2016). Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions. Biochemical Society Transactions, 44(3), 810-823. https://doi.org/10.1042/BST20160023

This article reviews current methods for the reliable heterologous overexpression in Escherichia coli and purification of milligram quantities of bacterial membrane sensor kinase (MSK) proteins belonging to the two-component signal transduction famil... Read More about Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions.

The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health (2016)
Journal Article
Horniblow, R. D., Latunde-Dada, G. O., Harding, S. E., Schneider, M., Almutairi, F. M., Sahni, M., …Tselepis, C. (2016). The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health. Molecular Nutrition and Food Research, 60(9), 2098-2108. https://doi.org/10.1002/mnfr.201500882

Scope Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been shown to exacerbate inflammatory bowel disease and intestinal cancer. Therefore, the aims of this study were... Read More about The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health.

A novel Brassica–rhizotron system to unravel the dynamic changes in root system architecture of oilseed rape under phosphorus deficiency (2016)
Journal Article
Yuan, P., Ding, G., Cai, H., Jin, K.-M., Broadley, M. R., Xu, F., & Shi, L. (in press). A novel Brassica–rhizotron system to unravel the dynamic changes in root system architecture of oilseed rape under phosphorus deficiency. Annals of Botany, 118(2), https://doi.org/10.1093/aob/mcw083

Background and Aims: An important adaptation of plants to phosphorus (P) deficiency is to alter root system architecture (RSA) to increase P acquisition from the soil, but soil-based observations of RSA are technically challenging, especially in matu... Read More about A novel Brassica–rhizotron system to unravel the dynamic changes in root system architecture of oilseed rape under phosphorus deficiency.

Effects of elevated soil CO2 concentration on growth and competition in a grass-clover mix (2016)
Journal Article
Smith, K. L., Lake, J. A., Steven, M. D., & Lomax, B. H. (in press). Effects of elevated soil CO2 concentration on growth and competition in a grass-clover mix. International Journal of Greenhouse Gas Control, https://doi.org/10.1016/j.ijggc.2016.04.032

To investigate potential environmental affects in the context of carbon dioxide (CO2) leakage from Carbon Capture and Storage (CCS) schemes. The ASGARD (Artificial Soil Gassing and Response Detection) facility was established, where CO2 can be inject... Read More about Effects of elevated soil CO2 concentration on growth and competition in a grass-clover mix.

The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm (2016)
Journal Article
Shorinola, O., Bird, N., Simmonds, J., Berry, S., Henriksson, T., Jack, P., …Uauy, C. (2016). The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm. Journal of Experimental Botany, 67(14), 4169-4178. https://doi.org/10.1093/jxb/erw194

The precocious germination of cereal grains before harvest, also known as pre-harvest sprouting, is an important source of yield and quality loss in cereal production. Pre-harvest sprouting is a complex grain defect and is becoming an increasing chal... Read More about The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm.

Plant ionomics: from elemental profiling to environmental adaptation (2016)
Journal Article
Huang, X.-Y., & Salt, D. E. (in press). Plant ionomics: from elemental profiling to environmental adaptation. Molecular Plant, 9(6), https://doi.org/10.1016/j.molp.2016.05.003

Ionomics is a high-throughput elemental profiling approach to study the molecular mechanistic basis underlying mineral nutrient and trace element composition (also known as the ionome) of living organisms. Since the concept of ionomics was first intr... Read More about Plant ionomics: from elemental profiling to environmental adaptation.

Evidence of Mycobacterium tuberculosis Complex bacteraemia in intradermal skin test positive cattle detected using phage-RPA (2016)
Journal Article
Swift, B., Convery, T., & Rees, C. (2016). Evidence of Mycobacterium tuberculosis Complex bacteraemia in intradermal skin test positive cattle detected using phage-RPA. Virulence, 7(7), 779-788. https://doi.org/10.1080/21505594.2016.1191729

Bovine tuberculosis is a zoonotic infectious disease caused by Mycobacterium bovis 19 that affects cattle and can cause tuberculosis in a range of wildlife animals. A 20 bacteriophage-based method combined with PCR (phage-PCR) has been recently used... Read More about Evidence of Mycobacterium tuberculosis Complex bacteraemia in intradermal skin test positive cattle detected using phage-RPA.

Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK (2016)
Journal Article
Liu, Q.-M., Yang, Y., Maleki, S. J., Alcocer, M., Xu, S.-S., Shi, C.-L., …Liu, G.-M. (in press). Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK. Journal of Agricultural and Food Chemistry, 64(22), https://doi.org/10.1021/acs.jafc.6b01086

Polysaccharides from Gracilaria lemaneiformis in particular possess various bioactive functions, but their antiallergic activity remains incompletely defined. Sulfated polysaccharide from Gracilaria lemaneiformis (GLSP) was obtained by water extracti... Read More about Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK.

Deep Machine Learning provides state-of-the-art performance in image-based plant phenotyping (2016)
Preprint / Working Paper
Pound, M. P., Burgess, A. J., Wilson, M. H., Atkinson, J. A., Griffiths, M., Jackson, A. S., …French, A. P. Deep Machine Learning provides state-of-the-art performance in image-based plant phenotyping

Deep learning is an emerging field that promises unparalleled results on many data analysis problems. We show the success offered by such techniques when applied to the challenging problem of image-based plant phenotyping, and demonstrate state-of-th... Read More about Deep Machine Learning provides state-of-the-art performance in image-based plant phenotyping.

Direct and host-mediated interactions between Fusarium pathogens and herbivorous arthropods in cereals (2016)
Journal Article
Drakulic, J., Bruce, T., & Ray, R. V. (2017). Direct and host-mediated interactions between Fusarium pathogens and herbivorous arthropods in cereals. Plant Pathology, 66(1), 3-13. https://doi.org/10.1111/ppa.12546

Fusarium head blight and fusarium ear rot diseases of cereal crops are significant global problems, causing yield and grain quality losses and accumulation of harmful mycotoxins. Safety limits have been set by the European Commission for several Fusa... Read More about Direct and host-mediated interactions between Fusarium pathogens and herbivorous arthropods in cereals.

SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance (2016)
Journal Article
Asiani, K. R., Williams, H. E. L., Bird, L., Jenner, M., Searle, M. S., Hobman, J. L., …Soultanas, P. (2016). SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance. Molecular Microbiology, 101(5), 731-742. https://doi.org/10.1111/mmi.13399

Ag+ resistance was initially found on the Salmonella enetrica serovar Typhimurium multi-resistance plasmid pMG101 from burns patients in 1975. The putative model of Ag+ resistance, encoded by the sil operon from pMG101, involves export of Ag+ via an... Read More about SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance.

Molecular weight analysis of starches: which technique? (2016)
Journal Article
Harding, S. E., Adams, G. G., & Gillis, R. B. (2016). Molecular weight analysis of starches: which technique?. Starch/Stärke, 68(9-10), https://doi.org/10.1002/star.201600042

A number of methods are available to researchers for estimating molecular weights (molar masses) and molecular weight distributions of starches − or those in solution, using an appropriate solvent/solubilisation protocol. We outline the methods avail... Read More about Molecular weight analysis of starches: which technique?.

A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana (2016)
Journal Article
Muraro, D., Larrieu, A., Lucas, M., Chopard, J., Byrne, H. M., Godin, C., & King, J. R. (in press). A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana. Journal of Theoretical Biology, 404, https://doi.org/10.1016/j.jtbi.2016.04.036

The growth of the root of Arabidopsis thaliana is sustained by the meristem, a region of cell proliferation and differentiation which is located in the root apex and generates cells which move shootwards, expanding rapidly to cause root growth. The b... Read More about A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana.

Aspects of the analytical ultracentrifuge determination of the molar mass distribution of polysaccharides (2016)
Book Chapter
Harding, S. E., Adams, G. G., Gillis, R. B., Almutairi, F. M., & Morris, G. A. (2016). Aspects of the analytical ultracentrifuge determination of the molar mass distribution of polysaccharides. In S. Uchiyama, F. Arisaka, W. F. Stafford, & T. M. Laue (Eds.), Analytical ultracentrifugation: instrumentation, software and applications (375-386). Springer. https://doi.org/10.1007/978-4-431-55985-6_18

Molar mass or ‘molecular weight’ is one of the most fundamental parameters describing a macromolecule. Because of their polydisperse nature, polysaccharides are usually described by distributions of molar mass. SEC-MALS (size exclusion chromatography... Read More about Aspects of the analytical ultracentrifuge determination of the molar mass distribution of polysaccharides.

Sex ratios, virginity, and local resource enhancement in a quasisocial parasitoid (2016)
Journal Article
Kapranas, A., Hardy, I. C., Tang, X., Gardner, A., & Li, B. (2016). Sex ratios, virginity, and local resource enhancement in a quasisocial parasitoid. Entomologia Experimentalis et Applicata, 159(2), 243-251. https://doi.org/10.1111/eea.12418

Sclerodermus harmandi (Buysson) (Hymenoptera: Bethylidae) is an economically beneficial 2 species of parasitoid wasp that has an unusual level of sociality: groups of female foundresses 3 reproduce on a single host and exhibit cooperative post-ovipos... Read More about Sex ratios, virginity, and local resource enhancement in a quasisocial parasitoid.

Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio (2016)
Journal Article
Hardy, I. C., & Maalouf, W. E. (in press). Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio. Journal of Biosocial Science, https://doi.org/10.1017/S0021932016000146

Infertility affects around 15% of human couples and in many countries approximately 1–4% of babies are born following Assisted Reproductive Technologies (ART). Several ART techniques are used and these differentially affect the sex ratio of offspring... Read More about Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio.