All Outputs (27)

Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β (2013)
Journal Article
Williams, A., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2013). Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β. Arthritis Research and Therapy, 15(6), Article R223. https://doi.org/10.1186/ar4424

Introduction: Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metalloproteinases (MMPs) is partly... Read More about Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article
Sharquie, I. K., Al-Ghouleh, A., Fitton, P., Clark, M. R., Armour, K. L., Sewell, H. F., …Ghaemmaghami, A. M. (2013). An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14(Decemb), Article 12. https://doi.org/10.1186/1471-2172-14-54

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods (2013)
Journal Article
Charman, C., Venn, A., Ravenscroft, J., & Williams, H. (2013). Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods. British Journal of Dermatology, 169(6), https://doi.org/10.1111/bjd.12590

Background: The Patient-Oriented Eczema Measure (POEM) is a validated, patient-derived assessment measure for monitoring atopic eczema severity, although further information on how different POEM scores translate into disease severity categories is n... Read More about Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods.

Risk factors for wheezing in infants born in Cuba (2013)
Journal Article
Venero-Fernandez, S., Suarez-Medina, R., Mora-Faife, E., Garcia-Garcia, G., Valle-Infante, I., Gomez-Marrero, L., …Fogarty, A. W. (2013). Risk factors for wheezing in infants born in Cuba. QJM: An International Journal of Medicine, 106(11), https://doi.org/10.1093/qjmed/hct143

Background: Cuba is a unique country, and despite limited economic development, has an excellent health system. However, the prevalence of asthma symptoms in children in Havana, Cuba, is unusually high.

Aim: As early life exposures are critical t... Read More about Risk factors for wheezing in infants born in Cuba.

Preparation to care for confused older patients in general hospitals: a study of UK health professionals (2013)
Journal Article
Griffiths, A., Knight, A., Harwood, R. H., & Gladman, J. R. (2014). Preparation to care for confused older patients in general hospitals: a study of UK health professionals. Age and Ageing, 43(4), 521-527. https://doi.org/10.1093/ageing/aft171

Background and Objective: in the UK, two-thirds of patients in general hospitals are older than 70, of whom half have dementia or delirium or both. Our objective was to explore doctors, nurses and allied health professionals' perceptions of their pre... Read More about Preparation to care for confused older patients in general hospitals: a study of UK health professionals.

A psychometric comparison of two carer quality of life questionnaires in Huntington's disease: implications for neurodegenerative disorders - a response to: Hagell and Smith (2013) Journal of Huntington’s Disease 2(3) 315-322 (2013)
Journal Article
Aubeeluck, A., Buchanan, H., & Stupple, E. J. (2013). A psychometric comparison of two carer quality of life questionnaires in Huntington's disease: implications for neurodegenerative disorders - a response to: Hagell and Smith (2013) Journal of Huntington’s Disease 2(3) 315-322. Journal of Huntington's Disease, 2(4),

GSTCD and INTS12 regulation and expression in the human lung (2013)
Journal Article
Obeidat, M., Miller, S., Probert, K., Billington, C. K., Henry, A. P., Hodge, E., …Hall, I. P. (2013). GSTCD and INTS12 regulation and expression in the human lung. PLoS ONE, 8(9), Article e74630. https://doi.org/10.1371/journal.pone.0074630

Genome-Wide Association Study (GWAS) meta-analyses have identified a strong association signal for lung function, which maps to a region on 4q24 containing two oppositely transcribed genes: glutathione S-transferase, C-terminal domain containing (GST... Read More about GSTCD and INTS12 regulation and expression in the human lung.

Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of Helicobacter pylori (2013)
Journal Article
Grove, J. I., Alandiyjany, M. N., & Delahay, R. M. (2013). Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of Helicobacter pylori. Journal of Biological Chemistry, 288(37), https://doi.org/10.1074/jbc.M113.496430

Four different type IV secretion systems are variously represented in the genomes of different Helicobacter pylori strains. Two of these, encoded by tfs3 and tfs4 gene clusters are contained within self-transmissible genomic islands. Although chromos... Read More about Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of Helicobacter pylori.

Same-sex sexual identity development in an Indian context (2013)
Journal Article
Kumar Pandya, A., Pandya, S., & das Nair, R. (2013). Same-sex sexual identity development in an Indian context. Psychology of Sexualities Section Review, 4(1),

One of the challenges of writing a chapter on inter sectionality, with a specific emphasis on sexuality and ethnicity, is that specificity distorts the ideal of inter sectionality, which seeks to see people as multiple composites of identities, not s... Read More about Same-sex sexual identity development in an Indian context.

Alcohol imagery on popularly viewed television in the UK (2013)
Journal Article
Lyons, A., McNeill, A., & Britton, J. (2013). Alcohol imagery on popularly viewed television in the UK. Journal of Public Health, https://doi.org/10.1093/pubmed/fdt074

Background: Exposure to alcohol consumption and product imagery in films is associated with increased alcohol consumption among young people, but the extent to which exposure also occurs through television is not clear. We have measured the occurrenc... Read More about Alcohol imagery on popularly viewed television in the UK.

Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases (2013)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2013). Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases. British Journal of Cancer, 109, https://doi.org/10.1038/bjc.2013.383

Background: Bisphosphonates are the most commonly prescribed osteoporosis drugs but long-term effects are unclear, although antitumour properties are known from preclinical studies.
Methods: Nested case–control studies were conducted to investigate... Read More about Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases.

The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor (2013)
Journal Article
Patoli, A. A., Winter, J. A., & Bunting, K. A. (2013). The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor. BMC Structural Biology, 13(July), Article 13. https://doi.org/10.1186/1472-6807-13-12

Background
Strict regulation of replisome components is essential to ensure the accurate transmission of the genome to the next generation. The sliding clamp processivity factors play a central role in this regulation, interacting with both DNA poly... Read More about The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor.

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes (2013)
Journal Article
Corriden, R., Self, T., Akong-Moore, K., Nizet, V., Kellam, B., Briddon, S. J., & Hill, S. J. (2013). Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Reports, 14(8), https://doi.org/10.1038/embor.2013.89

The A3‐adenosine receptor (A3AR) has recently emerged as a key regulator of neutrophil behaviour. Using a fluorescent A3AR ligand, we show that A3ARs aggregate in highly polarized immunomodulatory microdomains on human neutrophil membranes. In additi... Read More about Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.

A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components (2013)
Journal Article
de Leon, J. C., Scheumann, N., Beatty, W., Beck, J. R., Tran, J. Q., Yau, C., …Morrissette, N. S. (2013). A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryotic Cell, 12(7), https://doi.org/10.1128/EC.00096-13

SAS-6 is required for centriole biogenesis in diverse eukaryotes. Here, we describe a novel family of SAS-6-like (SAS6L) proteins that share an N-terminal domain with SAS-6 but lack coiled-coil tails. SAS6L proteins are found in a subset of eukaryote... Read More about A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components.

Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation (2013)
Journal Article
Hashmani, K., Branch, M. J., Sidney, L. E., Dhillon, P. S., Verma, M., McIntosh, O. D., …Dua, H. S. (2013). Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation. Stem Cell Research and Therapy, 4(3), Article 75. https://doi.org/10.1186/scrt226

Introduction: The corneal stroma is being increasingly recognized as a repository for stem cells. Like the limbal and endothelial niches, stromal stem cells often reside in the peripheral cornea and limbus. These peripheral and limbal corneal stromal... Read More about Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation.

Universities, the public good and professional education in the UK (2013)
Journal Article
East, L., Stokes, R., & Walker, M. (2013). Universities, the public good and professional education in the UK. Studies in Higher Education, https://doi.org/10.1080/03075079.2013.801421

In times of economic uncertainty, questions of the purpose and value of higher education come to the fore. Such questions have particular relevance when directed towards the preparation of professionally qualified graduates who might be expected to c... Read More about Universities, the public good and professional education in the UK.

Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis (2013)
Journal Article
Narkwichean, A., Maalouf, W., Campbell, B. K., & Jayaprakasan, K. (2013). Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis. Reproductive Biology and Endocrinology, 11, Article 44. https://doi.org/10.1186/1477-7827-11-44

Women with diminished ovarian reserve often respond poorly to controlled ovarian stimulation resulting in retrieval of fewer oocytes and reduced pregnancy rates. It has been proposed that pre-IVF Dehydroepiandrosterone (DHEA) adjuvant therapy may imp... Read More about Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis.

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database (2013)
Journal Article
Coupland, C., Morriss, R., Arthur, A., Moore, M., Hill, T., & Hippisley-Cox, J. (2013). Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry, 13(135), https://doi.org/10.1186/1471-244X-13-135

Background: Antidepressants are among the most commonly prescribed drugs in primary care in England and their use is increasing. This is largely due to longer durations of treatment of depression. Observational studies have shown some differences in... Read More about Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database.

The forgotten smoker: a qualitative study of attitudes towards smoking, quitting, and tobacco control policies among continuing smokers (2013)
Journal Article
Uppal, N., Shahab, L., Britton, J., & Ratschen, E. (2013). The forgotten smoker: a qualitative study of attitudes towards smoking, quitting, and tobacco control policies among continuing smokers. BMC Public Health, 13(May), Article 9. https://doi.org/10.1186/1471-2458-13-432

Background: Although research suggests that the majority of smokers want to quit smoking, the uptake of Stop Smoking Services, designed to assist smokers with quitting, remains low. Little is known about continuing smokers who do not access these ser... Read More about The forgotten smoker: a qualitative study of attitudes towards smoking, quitting, and tobacco control policies among continuing smokers.

What do we tell patients about elective total hip replacement in the UK?: an analysis of patient literature (2013)
Journal Article
Drummond, A. E., Edwards, C., Coole, C., & Brewin, C. (2013). What do we tell patients about elective total hip replacement in the UK?: an analysis of patient literature. BMC Musculoskeletal Disorders, 14, Article 152. https://doi.org/10.1186/1471-2474-14-152

Background: Although hip information literature is given to people following total hip replacement (THR) almost routinely, little evaluation has been conducted on it to date. Our aim was therefore to analyse and evaluate the literature provided to pa... Read More about What do we tell patients about elective total hip replacement in the UK?: an analysis of patient literature.