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Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis

Narkwichean, Amarin; Maalouf, Walid; Campbell, Bruce K.; Jayaprakasan, Kannamannadiar

Authors

Amarin Narkwichean mzxan@nottingham.ac.uk

Walid Maalouf

Bruce K. Campbell

Kannamannadiar Jayaprakasan

Abstract

Women with diminished ovarian reserve often respond poorly to controlled ovarian stimulation resulting in retrieval of fewer oocytes and reduced pregnancy rates. It has been proposed that pre-IVF Dehydroepiandrosterone (DHEA) adjuvant therapy may improve ovarian response and pregnancy rates in women with diminished ovarian reserve. This meta-analysis aims to investigate efficacy of DHEA as an adjuvant to improve ovarian response and IVF outcome in women with diminished ovarian reserve. Electronic databases were searched under the following terms: (DHEA) and (diminished ovarian reserve) and/or (poor response). Studies were included if they reported at least one of the following outcomes; clinical pregnancy rate, number of oocytes retrieved, miscarriage rate. We identified 22 publications determining effects of DHEA in clinical trials. Only 3 controlled studies were eligible for meta-analysis. There was no significant difference in the clinical pregnancy rate and miscarriage rates between women pre-treated with DHEA compared to those without DHEA pre-treatment (RR 1.87, 95% CI 0.96-3.64; and RR 0.59, 95% CI 0.21-1.65, respectively). The number of oocytes retrieved (WMD -1.88, 95% CI -2.08, 1.67; P 

Journal Article Type Article
Publication Date May 16, 2013
Journal Reproductive Biology and Endocrinology
Electronic ISSN 1477-7827
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 11
Article Number 44
Institution Citation Narkwichean, A., Maalouf, W., Campbell, B. K., & Jayaprakasan, K. (2013). Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis. Reproductive Biology and Endocrinology, 11, doi:10.1186/1477-7827-11-44
DOI https://doi.org/10.1186/1477-7827-11-44
Publisher URL http://www.rbej.com/content/11/1/44
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0




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