All Outputs (84)

Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements (2021)
Journal Article
Zhang, Q., Pavanello, L., Potapov, A., Bartlam, M., & Winkler, G. S. (2022). Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Science, 31(3), 758-764. https://doi.org/10.1002/pro.4262

Regulated degradation of mature, cytoplasmic mRNA is a key step in eukaryotic gene regulation. This process is typically initiated by the recruitment of deadenylase enzymes by cis-acting elements in the 3' untranslated region resulting in the shorten... Read More about Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements.

Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents (2021)
Journal Article
Ottino-González, J., Albaugh, M. D., Cao, Z., Cupertino, R. B., Schwab, N., Spechler, P. A., Allen, N., Artiges, E., Banaschewski, T., Bokde, A. L. W., Burke Quinlan, E., Brühl, R., Orr, C., Cousijn, J., Desrivières, S., Flor, H., Foxe, J. J., Fröhner, J. H., Goudriaan, A. E., Gowland, P., …Garavan, H. (2022). Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents. Addiction, 117(5), 1312-1325. https://doi.org/10.1111/add.15772

BACKGROUND AND AIMS: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults wi... Read More about Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents.

Perspectives on COVID-19 prevention and treatment using herbal medicine in Vietnam: A cross-sectional study (2021)
Journal Article
Tran, V. D., Pham, D. T., Cao, T. T. N., Bahlol, M., Dewey, R. S., Le, M. H., & Nguyen, V. A. (2021). Perspectives on COVID-19 prevention and treatment using herbal medicine in Vietnam: A cross-sectional study. Annali di Igiene, Medicina Preventiva e di Comunità, 34(5), 515-531. https://doi.org/10.7416/ai.2021.2484

Introduction. The significance of herbal medicine (HM) during the COVID-19 pandemic has been confirmed. Nevertheless, limited studies have included the people perspectives on COVID-19 prevention/treatment using herbal medicine in Vietnam. Thus, this... Read More about Perspectives on COVID-19 prevention and treatment using herbal medicine in Vietnam: A cross-sectional study.

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma (2021)
Journal Article
Dury, R. J., Lourdusamy, A., Macarthur, D. C., Peet, A. C., Auer, D. P., Grundy, R. G., & Dineen, R. A. (2022). Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma. Journal of Magnetic Resonance Imaging, 56(1), 147-157. https://doi.org/10.1002/jmri.28007

Background: Medulloblastoma, ependymoma, and pilocytic astrocytoma are common pediatric posterior fossa tumors. These tumors show overlapping characteristics on conventional MRI scans, making diagnosis difficult. Purpose: To investigate whether appar... Read More about Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.

In silico evaluation and optimisation of magnetic resonance elastography of the liver (2021)
Journal Article
McGrath, D. M., Bradley, C. R., & Francis, S. T. (2021). In silico evaluation and optimisation of magnetic resonance elastography of the liver. Physics in Medicine and Biology, 66(22), Article 225005. https://doi.org/10.1088/1361-6560/ac3263

Objective. Magnetic resonance elastography (MRE) is widely adopted as a biomarker of liver fibrosis. However, in vivo MRE accuracy is difficult to assess. Approach. Finite element model (FEM) simulation was employed to evaluate liver MRE accuracy and... Read More about In silico evaluation and optimisation of magnetic resonance elastography of the liver.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., Argyriou, K., Lobo, A., Lung, P., Baldwin-Cleland, R., Sahnan, K., Hart, A., Limdi, J. K., McLaughlin, J., Atkinson, D., Parker, G. J. M., O’Connor, J. P. B., Little, R. A., Gowland, P. A., & Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Global urbanicity is associated with brain and behaviour in young people (2021)
Journal Article
Xu, J., Liu, X., Li, Q., Goldblatt, R., Qin, W., Liu, F., Chu, C., Luo, Q., Ing, A., Guo, L., Liu, N., Liu, H., Huang, C., Cheng, J., Wang, M., Geng, Z., Zhu, W., Zhang, B., Liao, W., Qiu, S., …Schumann, G. (2022). Global urbanicity is associated with brain and behaviour in young people. Nature Human Behaviour, 6(2), 279-293. https://doi.org/10.1038/s41562-021-01204-7

Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867).... Read More about Global urbanicity is associated with brain and behaviour in young people.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., Gowland, P., & Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics (2021)
Journal Article
Rier, L., Zamyadi, R., Zhang, J., Emami, Z., Seedat, Z. A., Mocanu, S., Gascoyne, L. E., Allen, C. M., Scadding, J. W., Furlong, P. L., Gooding-Williams, G., Woolrich, M. W., Evangelou, N., Brookes, M. J., & Dunkley, B. T. (2021). Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics. NeuroImage: Clinical, 32, Article 102841. https://doi.org/10.1016/j.nicl.2021.102841

Mild traumatic brain injury (mTBI) poses a considerable burden on healthcare systems. Whilst most patients recover quickly, a significant number suffer from sequelae that are not accompanied by measurable structural damage. Understanding the neural u... Read More about Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics.

Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model (2021)
Journal Article
Penninck, L., Ibrahim, E. C., Artiges, E., Gorgievski, V., Desrivières, S., Farley, S., Filippi, I., de Macedo, C. E. A., Belzeaux, R., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Nees, F., Papadopoulos Orfanos, D., …Martinot, J.-L. (2021). Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model. Frontiers in Systems Neuroscience, 15, 1-14. https://doi.org/10.3389/fnsys.2021.725413

Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia. Chronic neuroinflammation is considered to pl... Read More about Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.

The role of hepatic lipid composition in obesity-related metabolic disease (2021)
Journal Article
Willis, S. A., Bawden, S., Malaikah, S., Sargeant, J. A., Stensel, D. J., Aithal, G. P., & King, J. A. (2021). The role of hepatic lipid composition in obesity-related metabolic disease. Liver International, 41(12), 2819-2835. https://doi.org/10.1111/liv.15059

Obesity is a primary antecedent to non-alcoholic fatty liver disease whose cardinal feature is excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates with hepatic and systemic metabolic dysfunction, accumulating... Read More about The role of hepatic lipid composition in obesity-related metabolic disease.

Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation (2021)
Journal Article
Elkrief, L., Lin, B., Marchi, M., Afzali, M. H., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Desrivières, S., Flor, H., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot, M.-L. P., Nees, F., Orfanos, D. P., Paus, T., Poustka, L., Hohmann, S., …Consortium, I. (2023). Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation. Psychological Medicine, 53(5), 1759-1769. https://doi.org/10.1017/s0033291721003378

Background
It has not yet been determined if the commonly reported cannabis–psychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders.

Methods
We examined whether the relationship between polygenic ri... Read More about Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging (2021)
Journal Article
O’Farrell, C., Hoad, C. L., Stamatopoulos, K., Marciani, L., Sulaiman, S., Simmons, M. J. H., & Batchelor, H. K. (2021). Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging. Pharmaceutics, 13(10), Article 1545. https://doi.org/10.3390/pharmaceutics13101545

Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us... Read More about Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging.

Similarity and stability of face network across populations and throughout adolescence and adulthood (2021)
Journal Article
Liao, Z., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J. L., Martinot, M.-L. P., Artiges, E., Nees, F., Orfanos, D. P., Poustka, L., Hohmann, S., Millenet, S., Fröhner, J. H., Smolka, M. N., …Paus, T. (2021). Similarity and stability of face network across populations and throughout adolescence and adulthood. NeuroImage, 244, Article 118587. https://doi.org/10.1016/j.neuroimage.2021.118587

The ability to extract cues from faces is fundamental for social animals, including humans. An individual's profile of functional connectivity across a face network can be shaped by common organizing principles, stable individual traits, and time-var... Read More about Similarity and stability of face network across populations and throughout adolescence and adulthood.

The Human Connectome Project: A retrospective (2021)
Journal Article
Elam, J. S., Glasser, M. F., Harms, M. P., Sotiropoulos, S. N., Andersson, J. L., Burgess, G. C., Curtiss, S. W., Oostenveld, R., Larson-Prior, L. J., Schoffelen, J. M., Hodge, M. R., Cler, E. A., Marcus, D. M., Barch, D. M., Yacoub, E., Smith, S. M., Ugurbil, K., & Van Essen, D. C. (2021). The Human Connectome Project: A retrospective. NeuroImage, 244, Article 118543. https://doi.org/10.1016/j.neuroimage.2021.118543

The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study a large number of healthy young adults; and fr... Read More about The Human Connectome Project: A retrospective.

Willingness of Healthcare Students in Vietnam to Volunteer During the COVID-19 Pandemic (2021)
Journal Article
Tran, V. D., Pham, D. T., Dao, T. N. P., Pham, K. A. T., Ngo, P. T., & Dewey, R. S. (2022). Willingness of Healthcare Students in Vietnam to Volunteer During the COVID-19 Pandemic. Journal of Community Health, 47(1), 108-117. https://doi.org/10.1007/s10900-021-01030-y

Healthcare students play an important role in volunteering activity, often addressing staff shortages. However, during the COVID-19 pandemic, the willingness of students to volunteer in contribution to the pandemic response, especially in Vietnam, ha... Read More about Willingness of Healthcare Students in Vietnam to Volunteer During the COVID-19 Pandemic.

Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients (2021)
Journal Article
Jewell, A., Williams, H., Hoad, C. L., Gellert, P. R., Ashford, M. B., Butler, J., Stolnik, S., Scurr, D., Stocks, M. J., Marciani, L., Gowland, P. A., & Gershkovich, P. (2021). Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients. Pharmaceutics, 13(9), Article 1343. https://doi.org/10.3390/pharmaceutics13091343

Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was... Read More about Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients.

Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset? (2021)
Journal Article
Schilling, K. G., Rheault, F., Petit, L., Hansen, C. B., Nath, V., Yeh, F. C., Girard, G., Barakovic, M., Rafael-Patino, J., Yu, T., Fischi-Gomez, E., Pizzolato, M., Ocampo-Pineda, M., Schiavi, S., Canales-Rodríguez, E. J., Daducci, A., Granziera, C., Innocenti, G., Thiran, J. P., Mancini, L., …Descoteaux, M. (2021). Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?. NeuroImage, 243, Article 118502. https://doi.org/10.1016/j.neuroimage.2021.118502

White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability i... Read More about Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?.

Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model (2021)
Journal Article
Plas, M. C. E., Craig, M., Schmid, S., Chappell, M. A., & Osch, M. J. P. (2022). Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model. Magnetic Resonance in Medicine, 87(1), 85-101. https://doi.org/10.1002/mrm.28960

Purpose
In this paper, the ability to quantify cerebral blood flow by arterial spin labeling (ASL) was studied by investigating the separation of the macrovascular and tissue component using a 2-component model. Underlying assumptions of this model,... Read More about Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model.