All Outputs (112)

Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution (2021)
Journal Article
Vaud, S., Pearcy, N., Hanževački, M., Van Hagen, A. M., Abdelrazig, S., Safo, L., …Bryan, S. J. (2021). Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution. Metabolic Engineering, 67, 308-320. https://doi.org/10.1016/j.ymben.2021.07.001

Ethylene is a small hydrocarbon gas widely used in the chemical industry. Annual worldwide production currently exceeds 150 million tons, producing considerable amounts of CO2 contributing to climate change. The need for a sustainable alternative is... Read More about Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model (2021)
Journal Article
Markides, H., Foster, N. C., McLaren, J. S., Hopkins, T., Black, C., Oreffo, R. O. C., …El Haj, A. J. (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, 10(7), Article 1776. https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.

In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease (2021)
Journal Article
Uras, G., Manca, A., Zhang, P., Markus, Z., Mack, N., Allen, S., …Zhu, Z. (2021). In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease. Frontiers in Neuroscience, 15, Article 691222. https://doi.org/10.3389/fnins.2021.691222

Alzheimer’s disease is a neurodegenerative disease characterized by disrupted memory, learning functions, reduced life expectancy, and locomotor dysfunction, as a result of the accumulation and aggregation of amyloid peptides that cause neuronal dama... Read More about In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease.

De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization (2021)
Journal Article
Okesola, B. O., Mendoza-Martinez, A. K., Cidonio, G., Derkus, B., Boccorh, D. K., Osuna de la Peña, D., …Mata, A. (2021). De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization. ACS Nano, 15(7), 11202–11217. https://doi.org/10.1021/acsnano.0c09814

Synthetic nanostructured materials incorporating both organic and inorganic components offer a unique, powerful and versatile class of materials for widespread applications due to the distinct, yet complementary, nature of the intrinsic properties of... Read More about De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization.

Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells (2021)
Journal Article
Conte, C., Monteiro, P., Gurnani, P., Stolnik, S., Ungaro, F., Quaglia, F., …Alexander, C. (2021). Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells. Nanoscale, 13(26), 11414-11426. https://doi.org/10.1039/d1nr02179f

Bioresponsive nanoparticles (NPs) are of interest for anticancer nanomedicines, owing to the possibility to ‘design in’ selective modulation of drug release at target sites. Here we describe the double emulsion formulation of redox-responsive NPs bas... Read More about Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells.

Collaboration between adult patients and practitioners when making decisions about prescribing opioid medicines for chronic non-cancer pain in primary care: a scoping review (2021)
Journal Article
Bathia, N. S., McAskill, R. E., Hancox, J. E., & Knaggs, R. D. (2022). Collaboration between adult patients and practitioners when making decisions about prescribing opioid medicines for chronic non-cancer pain in primary care: a scoping review. British Journal of Pain, 16(1), 119-126. https://doi.org/10.1177/20494637211025560

Background: Long-term opioid therapy (>12 months) is not effective for improving chronic non-cancer pain and function. Where patients are not experiencing pain relief with long-term opioids, the opioid should be tapered and discontinuation considered... Read More about Collaboration between adult patients and practitioners when making decisions about prescribing opioid medicines for chronic non-cancer pain in primary care: a scoping review.

Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation (2021)
Journal Article
Hollmann, B., Perkins, M., Chauhan, V. M., Aylott, J. W., & Hardie, K. R. (2021). Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation. npj Biofilms and Microbiomes, 7(1), Article 50. https://doi.org/10.1038/s41522-021-00221-8

Understanding the dynamic environmental microniches of biofilms will permit us to detect, manage and exploit these communities. The components and architecture of biofilms have been interrogated in depth; however, little is known about the environmen... Read More about Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation.

Topographically guided hierarchical mineralization (2021)
Journal Article
Deng, X., Hasan, A., Elsharkawy, S., Tejeda-Montes, E., Tarakina, N. V., Greco, G., …Mata, A. (2021). Topographically guided hierarchical mineralization. Materials Today Bio, 11, Article 100119. https://doi.org/10.1016/j.mtbio.2021.100119

Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated m... Read More about Topographically guided hierarchical mineralization.

Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants (2021)
Journal Article
Henshaw, C. A., Dundas, A. A., Cuzzucoli Crucitti, V., Alexander, M. R., Wildman, R., Rose, F. R. A. J., …Williams, P. M. (2021). Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants. Molecules, 26(11), Article 3302. https://doi.org/10.3390/molecules26113302

Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polyme... Read More about Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants.

Explorative Research on Health Literacy and Self-care Management in Patients with Type 2 Diabetes Mellitus (2021)
Journal Article
Ely, A., Azhari, A., Chai, J., & Anderson, C. (2021). Explorative Research on Health Literacy and Self-care Management in Patients with Type 2 Diabetes Mellitus. Malaysian Journal of Qualitative Research, 7(1), 40-52

Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition which is associated with high blood sugar, insulin resistance and relative lack of insulin. This qualitative research explores newly diagnosed T2DM patients' perceptions on disease know... Read More about Explorative Research on Health Literacy and Self-care Management in Patients with Type 2 Diabetes Mellitus.

Magnesium isoglycyrrhizinate reduces hepatic lipotoxicity through regulating metabolic abnormalities (2021)
Journal Article
Lu, L., Hao, K., Hong, Y., Liu, J., Zhu, J., Jiang, W., …Peng, Y. (2021). Magnesium isoglycyrrhizinate reduces hepatic lipotoxicity through regulating metabolic abnormalities. International Journal of Molecular Sciences, 22(11), Article 5884. https://doi.org/10.3390/ijms22115884

The excessive accumulation of lipids in hepatocytes induces a type of cytotoxicity called hepatic lipotoxicity, which is a fundamental contributor to liver metabolic diseases (such as NAFLD). Magnesium isoglycyrrhizinate (MGIG), a magnesium salt of t... Read More about Magnesium isoglycyrrhizinate reduces hepatic lipotoxicity through regulating metabolic abnormalities.

Enhancing employability opportunities for Pharmacy students; a case study of processes to implement competency‐based education in Pharmacy in Kenya (2021)
Journal Article
Ruparelia, J., McMullen, J., Anderson, C., Munene, D., & Arakawa, N. (2021). Enhancing employability opportunities for Pharmacy students; a case study of processes to implement competency‐based education in Pharmacy in Kenya. Higher Education Quarterly, 75(4), 608-617. https://doi.org/10.1111/hequ.12319

This paper challenges the western concept of graduate employability as a measure of student success through a case study of a collaboration between pharmacy colleagues in universities in Nairobi, Kenya and Nottingham, UK. As Pharmacy programmes globa... Read More about Enhancing employability opportunities for Pharmacy students; a case study of processes to implement competency‐based education in Pharmacy in Kenya.

Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding (2021)
Journal Article
Radvar, E., Griffanti, G., Tsolaki, E., Bertazzo, S., Nazhat, S. N., Addison, O., …Elsharkawy, S. (2021). Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding. Advanced NanoBiomed Research, 1(8), Article 2100042. https://doi.org/10.1002/anbr.202100042

Physiological calcification plays an essential part in the development of the skeleton and teeth; however, the occurrence of calcification in soft tissues such as the brain, heart, and kidneys associates with health impacts, creating a massive social... Read More about Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding.

Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease (2021)
Journal Article
Yao, H., Uras, G., Zhang, P., Xu, S., Yin, Y., Liu, J., …Xu, J. (2021). Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease. Journal of Medicinal Chemistry, 64(11), 7483-7506. https://doi.org/10.1021/acs.jmedchem.1c00160

Based on a multitarget strategy, a series of novel tacrine–pyrimidone hybrids were identified for the potential treatment of Alzheimer’s disease (AD). Biological evaluation results demonstrated that these hybrids exhibited significant inhibitory acti... Read More about Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease.

The association between incident vertebral deformities, health-related quality of life and functional impairment: a 10.7-year cohort study (2021)
Journal Article
Shah, A., Wu, F., Jones, G., Cicuttini, F., Toh, L., & Laslett, L. (2021). The association between incident vertebral deformities, health-related quality of life and functional impairment: a 10.7-year cohort study. Osteoporosis International, 32(11), 2247-2255. https://doi.org/10.1007/s00198-021-06004-3

We aimed to describe longitudinal changes in health-related quality of life (HRQoL) measures associated with incident vertebral deformities (VDs) over 10.7 years. Incident VDs are associated with clinically significant functional impairment in men, a... Read More about The association between incident vertebral deformities, health-related quality of life and functional impairment: a 10.7-year cohort study.

High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS (2021)
Journal Article
Hook, A. L., Hogwood, J., Gray, E., Mulloy, B., & Merry, C. L. (2021). High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS. Communications Chemistry, 4, Article 67. https://doi.org/10.1038/s42004-021-00506-1

Glycosaminoglycans (GAGs) are important biopolymers that differ in the sequence of saccharide units and in post polymerization alterations at various positions, making these complex molecules challenging to analyse. Here we describe an approach that... Read More about High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS.

Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release (2021)
Journal Article
Adala, I., Ramis, J., Ntone Moussinga, C., Janowski, I., Amer, M. H., Bennett, A. J., …Rose, F. R. (2021). Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release. Journal of Materials Chemistry B, 9(20), 4120-4133. https://doi.org/10.1039/d1tb00129a

Effective regenerative medicine requires delivery systems which can release multiple components at appropriate levels and at different phases of tissue growth and repair. However, there are few biomaterials and encapsulation techniques that are fully... Read More about Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release.

Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles (2021)
Journal Article
Trindade, G. F., Wang, F., Im, J., He, Y., Balogh, A., Scurr, D., …Roberts, C. J. (2021). Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles. Communications Materials, 2(1), Article 47. https://doi.org/10.1038/s43246-021-00151-0

Inkjet printing of metal nanoparticles allows for design flexibility, rapid processing and enables the 3D printing of functional electronic devices through co-deposition of multiple materials. However, the performance of printed devices, especially t... Read More about Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles.

Is Europe also facing an opioid crisis? ‐ A survey of European Pain Federation chapters (2021)
Journal Article
Häuser, W., Buchser, E., Finn, D., Dom, G., Fors, E., Heiskanen, T., …Morlion, B. (2021). Is Europe also facing an opioid crisis? ‐ A survey of European Pain Federation chapters. European Journal of Pain, 25(8), 1760-1769. https://doi.org/10.1002/ejp.1786

Background There is considerable public interest in whether Europe is facing an opioid crisis comparable to the one in the United States and the contribution of opioid prescriptions for pain to a potential opioid crisis. Methods A task force... Read More about Is Europe also facing an opioid crisis? ‐ A survey of European Pain Federation chapters.

Inkjet 3D Printing of Polymers Resistant to Fungal Attachment (2021)
Journal Article
He, Y., Vallières, C., Alexander, M. R., Wildman, R. D., & Avery, S. V. (2021). Inkjet 3D Printing of Polymers Resistant to Fungal Attachment. Bio-protocol, 11(9), Article e4016. https://doi.org/10.21769/BioProtoc.4016

Inkjet 3D printing is an additive manufacturing method that allows the user to produce a small batch of customized devices for comparative study versus commercial products. Here, we describe the use of a commercial 2D ink development system (Dimatix... Read More about Inkjet 3D Printing of Polymers Resistant to Fungal Attachment.