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Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning (2013)
Journal Article
Swan, A. L., Hillier, K. L., Smith, J. R., Allaway, D., Liddell, S., Bacardit, J., & Mobasheri, A. (2013). Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning. BMC Musculoskeletal Disorders, 14, Article 349. https://doi.org/10.1186/1471-2474-14-349

Background: Osteoarthritis (OA) is an inflammatory disease of synovial joints involving the loss and degeneration of articular cartilage. The gold standard for evaluating cartilage loss in OA is the measurement of joint space width on standard radiog... Read More about Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning.

Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator (2012)
Journal Article
Mobasheri, A. (2012). Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator. Frontiers in Endocrinology, 3(153), Article 153. https://doi.org/10.3389/fendo.2012.00153

In the skeletal system glucose serves as an essential source of energy for the development, growth, and maintenance of bone and articular cartilage. It is particularly needed for skeletal morphogenesis during embryonic growth and fetal development. G... Read More about Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator.

Intersection of inflammation and herbal medicine in the treatment of osteoarthritis (2012)
Journal Article
Mobasheri, A. (2012). Intersection of inflammation and herbal medicine in the treatment of osteoarthritis. Current Rheumatology Reports, 14(6), https://doi.org/10.1007/s11926-012-0288-9

Herbal remedies and dietary supplements have become an important area of research and clinical practice in orthopaedics and rheumatology. Understanding the risks and benefits of using herbal medicines in the treatment of arthritis, rheumatic diseases... Read More about Intersection of inflammation and herbal medicine in the treatment of osteoarthritis.

Dairy herd health (2012)
Book
Green, M., Bradley, A., Breen, J., Green, L., Hayton, A., Higgins, H., Hudson, C., Huxley, J., & Statham, J. (Eds.). (2012). Dairy herd health. CABI

Dairy herd health is an important and universal topic in large animal veterinary practice and farming, covering both preventive medicine and health promotion. With the move towards large-scale farming, the health of the herd is important as an econom... Read More about Dairy herd health.

Managing herd reproduction (2012)
Book Chapter
Hudson, C., Kerby, M., Statham, J., & Wapenaar, W. (2012). Managing herd reproduction. In Dairy herd health (73-116). CAB International

Keeping an open mind: highlights and controversies of the breast cancer stem cell theory (2012)
Journal Article
Shah, M., & Allegrucci, C. (2012). Keeping an open mind: highlights and controversies of the breast cancer stem cell theory. Breast Cancer: Targets and Therapy, 2012(4), https://doi.org/10.2147/BCTT.S26434

The discovery that breast cancers contain stem-like cells has fuelled exciting research in the last few years. These cells are referred to as breast cancer stem cells (BCSCs) and are thought to be involved in tumor initiation, progression, and metast... Read More about Keeping an open mind: highlights and controversies of the breast cancer stem cell theory.

The challenge of Schmallenberg virus emergence in Europe (2012)
Journal Article
Tarlinton, R., Daly, J. M., Dunham, S. P., & Kydd, J. M. (2012). The challenge of Schmallenberg virus emergence in Europe. Veterinary Journal, 194(1), 10-18. https://doi.org/10.1016/j.tvjl.2012.08.017

The large-scale outbreak of disease across Northern Europe caused by a new orthobunyavirus known as
Schmallenberg virus has caused considerable disruption to lambing and calving. Although advances in
technology and collaboration between veterinary... Read More about The challenge of Schmallenberg virus emergence in Europe.

Reliability of quantitative echocardiography in adult sheep and goats (2012)
Journal Article
Hallowell, G. D., Potter, T. J., & Bowen, I. M. (2012). Reliability of quantitative echocardiography in adult sheep and goats. BMC Veterinary Research, 8(Septem), Article 11. https://doi.org/10.1186/1746-6148-8-181

Background
Echocardiography is a non-invasive method for assessment of the ovine and caprine heart. Complete reference ranges for cardiac dimensions and time indices for both species are not currently available and reliability of these measurements... Read More about Reliability of quantitative echocardiography in adult sheep and goats.

Koala retrovirus endogenisation in action (2012)
Book Chapter
Tarlinton, R. E. (2012). Koala retrovirus endogenisation in action. In G. Witzany (Ed.), Viruses: Essential Agents of Life (283-291). Springer. https://doi.org/10.1007/978-94-007-4899-6_14

Koala retrovirus (KoRV) is a unique example of a retroviral group -currently undergoing the process of endogenisation. While endogenous retroviruses (ERVs) are ubiquitous elements in vertebrate genomes there is currently little understanding of the p... Read More about Koala retrovirus endogenisation in action.

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female (2012)
Journal Article
Dottorini, T., Persampieri, T., Palladino, P., Baker, D. A., Spaccapelo, R., Senin, N., & Crisanti, A. (2013). Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female. FASEB Journal, 27(1), 86-97. https://doi.org/10.1096/fj.12-219444

In Drosophila, the accessory gland proteins (Acps) secreted from the male accessory glands (MAGs) and transferred along with sperm into the female reproductive tract have been implicated in triggering postmating behavioral changes, including refracto... Read More about Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.

A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design (2012)
Journal Article
Higgins, H., Dryden, I. L., & Green, M. J. (2012). A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design. Preventive Veterinary Medicine, 106(2), https://doi.org/10.1016/j.prevetmed.2012.01.017

The two key aims of this research were: (i) to conduct a probabilistic elicitation to quantify the variation in veterinarians’ beliefs regarding the efficacy of systemic antibiotics when used as an adjunct to intra-mammary dry cow therapy and (ii) to... Read More about A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design.

Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census (2012)
Journal Article
Stavisky, J., Brennan, M. L., Downes, M. J., & Dean, R. S. (2012). Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census. BMC Veterinary Research, 8, Article 163. https://doi.org/10.1186/1746-6148-8-163

Background

The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease. Little information exists to describe this population, its dynamics and associated management... Read More about Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census.

Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates (2012)
Journal Article
Redshaw, Z., & Loughna, P. T. (2012). Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates. Differentiation, 84(2), https://doi.org/10.1016/j.diff.2012.06.001

The physiological oxygen concentration of many tissues is far lower than that in which cells are typically cultured in vitro and this may inadvertently influence the proliferation and differentiation potential of many cell types. Muscle derived stem... Read More about Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates.

Geriatric screening in first opinion practice: results from 45 dogs (2012)
Journal Article
Davies, M. (2012). Geriatric screening in first opinion practice: results from 45 dogs. Journal of Small Animal Practice, 53(9), https://doi.org/10.1111/j.1748-5827.2012.01247.x

Objectives
To evaluate and report the results of screening geriatric dogs in a first opinion practice.
Methods
A prospective health screen of dogs over nine-years-old involving history taking, physical examination and urinalysis.
Results
At leas... Read More about Geriatric screening in first opinion practice: results from 45 dogs.

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release (2012)
Journal Article
Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Perez, B., Pengxiang, C., Ghaemmaghami, A. M., Brookes, S. M., Brown, I. H., & Chang, K.-C. (2012). Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release. Journal of Virology, 86(17), https://doi.org/10.1128/JVI.00244-12

Respiratory epithelial cells and macrophages are the key innate immune cells that play an important role in the pathogenesis of influenza A virus infection. We found that these two cell types from both human and pig showed comparable susceptibilities... Read More about Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release.

Altered placental expression of kisspeptin and its receptor in pre-eclampsia (2012)
Journal Article
Cartwright, J. E., & Williams, P. J. (2012). Altered placental expression of kisspeptin and its receptor in pre-eclampsia. Journal of Endocrinology, 214(1), https://doi.org/10.1530/JOE-12-0091

Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy. Roles indicated for kisspeptin in pregnancy include regulating trophoblast invasion and migration d... Read More about Altered placental expression of kisspeptin and its receptor in pre-eclampsia.

Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle (2012)
Journal Article
Egan, S. A., Ward, P. N., Watson, M., Field, T. R., & Leigh, J. A. (in press). Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle. Microbiology, 158, https://doi.org/10.1099/mic.0.055863-0

The regulation and control of gene expression in response to differing environmental stimuli is crucial for successful pathogen adaptation and persistence. The regulatory gene vru of Streptococcus uberis encodes a stand-alone response regulator with... Read More about Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle.