All Outputs (4)

Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication (2025)
Journal Article
Romero, M., Luckett, J., Dubern, J.-F., Figueredo, G. P., Ison, E., Carabelli, A. M., Scurr, D. J., Hook, A. L., Kammerling, L., Da Silva, A. C., Xue, X., Blackburn, C., Carlier, A., Vasilevich, A., Sudarsanam, P. K., Vermeulen, S., Winkler, D. A., Ghaemmaghami, A. M., De Boer, J., Alexander, M. R., & Williams, P. (2025). Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication. Nature Communications, 16(1), Article 5295. https://doi.org/10.1038/s41467-025-60567-x

Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed... Read More about Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.

Biotin receptor-mediated intracellular delivery of synthetic polypeptide-protein complexes (2023)
Journal Article
Li, H., Bruce, G., Childerhouse, N., Keegan, G., Mantovani, G., & Stolnik, S. (2023). Biotin receptor-mediated intracellular delivery of synthetic polypeptide-protein complexes. Journal of Controlled Release, 357, 333-341. https://doi.org/10.1016/j.jconrel.2023.03.051

Pulmonary delivery offers a non-invasive route for the administration of biotherapeutics. In this context, understanding and control of a transport into, and across cellular barriers is central to the design of delivery systems. Here, we report our s... Read More about Biotin receptor-mediated intracellular delivery of synthetic polypeptide-protein complexes.

Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B (2018)
Journal Article
Tan Sui Ling, J., Roberts, C., & Billa, N. (2018). Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B. Pharmaceutical Development and Technology, 24(4), 504-512. https://doi.org/10.1080/10837450.2018.1515225

This study describes the properties of an amphotericin B-containing mucoadhesive nanostructured lipid carrier (NLC), with the intent to maximize uptake within the gastrointestinal tract. We have reported previously that lipid nanoparticles can signif... Read More about Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B.

H-IPSE is a pathogen-secreted host nucleus-infiltrating protein (Infiltrin) expressed exclusively by the Schistosoma haematobium egg stage (2017)
Journal Article
Pennington, L. F., Alouffi, A., Mbanefo, E. C., Ray, D., Heery, D. M., Jardetzky, T. S., Hsieh, M. H., & Falcone, F. H. (2017). H-IPSE is a pathogen-secreted host nucleus-infiltrating protein (Infiltrin) expressed exclusively by the Schistosoma haematobium egg stage. Infection and Immunity, 85(12), Article e00301-17. https://doi.org/10.1128/iai.00301-17

Urogenital schistosomiasis, caused by the parasitic trematode Schistosoma haematobium, affects over 112 million people worldwide. As with Schistosoma mansoni infections, the pathology of urogenital schistosomiasis is related mainly to the egg stage,... Read More about H-IPSE is a pathogen-secreted host nucleus-infiltrating protein (Infiltrin) expressed exclusively by the Schistosoma haematobium egg stage.