All Outputs (35)

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review (2020)
Journal Article
Schaffert, L.-N., & Carter, W. G. (2020). Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review. Brain Sciences, 10(4), Article 232. https://doi.org/10.3390/brainsci10040232

The accumulation of abnormal protein aggregates represents a universal hallmark of neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate protein structure and function. Dysregulated PTMs may influence the propensity for... Read More about Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review.

The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress (2019)
Journal Article
Al-Ghafari, A., Elmorsy, E., Fikry, E., Alrowaili, M., & Carter, W. G. (2019). The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress. PLoS ONE, 14(11), Article e0225341. https://doi.org/10.1371/journal.pone.0225341

The heavy metals (HMs) lead and cadmium are persistent environmental pollutants capable of inducing ill-health in exposed individuals. One of the primary sites of accumulation and potential damage from HMs is bone, and we therefore examined the acute... Read More about The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress.

A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism (2019)
Journal Article
Jones, J., Dorling, J. L., Clayton, D. J., King, J. A., Carter, W. G., Thackray, A. E., …Stensel, D. J. (2019). A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism. American Journal of Clinical Nutrition, 110(5), 1055-1066. https://doi.org/10.1093/ajcn/nqz188

Copyright © American Society for Nutrition 2019. BACKGROUND: The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is associated with higher acyl-ghrelin (AG) concentrations, higher energy intake, and obesity, although exercise may mitiga... Read More about A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism.

An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress (2019)
Journal Article
Nwidu, L. L., Alikwe, P. C. N., Elmorsy, E., & Carter, W. G. (2019). An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress. Medicines, 6(1), Article 15. https://doi.org/10.3390/medicines6010015

Background: Diets rich in fruits, vegetables, and medicinal plants possess antioxidants potentially capable of mitigating cellular oxidative stress. This study investigated the antioxidant, anti-acetylcholinesterase (AChE), and total phenolic and fla... Read More about An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress.

Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae) (2018)
Journal Article
Lucky, L., Yibali, O., Ekramy, E., & Wayne, C. (2018). Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae). Journal of Basic and Clinical Physiology and Pharmacology, 29(6), 609-619. https://doi.org/10.1515/jbcpp-2017-0058

Background

Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims.
Methods

A hepato-protective role of G. brevis hydromet... Read More about Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae).

In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., Aprioku, J., Siminialayi, I., & Carter, W. (2018). In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria. Medicines, 5(3), Article 71. https://doi.org/10.3390/medicines5030071

This study evaluated Moringa oleifera extracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts of Moringa oleifera were evaluated for inhibition of acetylcholin... Read More about In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria.

Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress (2018)
Journal Article
Nwidu, L. L., Oboma, Y. I., Elmorsy, E., & Carter, W. G. (2018). Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress. Journal of Taibah University Medical Sciences, 13(4), https://doi.org/10.1016/j.jtumed.2018.04.006

Objective: Natural antioxidant products are gaining popularity as treatments for various pathological liver injuries. Musanga cecropioides (Urticaceae) leaf extract is used in ethnomedicine for the management of jaundice and other hepatic ailments in... Read More about Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress.

In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., & Carter, W. (2018). In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria. Malaysian Journal of Medical Sciences, 25(2), https://doi.org/10.21315/mjms2018.25.2.4

Background: Polyherbal standardised extracts used in ethnomedicine of Eastern Nigeria for memory improvements were evaluated for anti-cholinesterases and anti-oxidant properties.

Methods: Anti-cholinesterase, anti-oxidant, and total phenolic and f... Read More about In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria.

Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., Yibala, O. I., & Carter, W. (2018). Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity. Journal of Taibah University Medical Sciences, 13(3), https://doi.org/10.1016/j.jtumed.2018.03.006

Objective

Spondias mombin L. is a tree used in folk medicine in Nigeria for the treatment of hepatitis. This study was carried out to comparatively evaluate the hepatoprotective and antioxidant effects of S. mombin leaf and stem (SML and SMS) meth... Read More about Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity.

Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Almutairi, F. M., Aggour, A. M., & Carter, W. (2017). Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations. Toxicology in Vitro, 44, https://doi.org/10.1016/j.tiv.2017.07.011

Antidepressants are commonly employed for the treatment of major depressive disorders and other psychiatric conditions. We investigated the relatively acute cytotoxic effects of three commonly prescribed antidepressants: fluoxetine, sertraline, and c... Read More about Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations.

Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics (2016)
Journal Article
Elmorsy, E., Attalla, S., Fikry, E., Kocon, A., Turner, R., Christie, D., …Carter, W. (in press). Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics. Human and Experimental Toxicology, https://doi.org/10.1177/0960327116660751

Tuberculosis (TB) is an intractable chronic infection. Disease treatment with anti-TB drugs remains challenging due to drug-induced hepatotoxicity. The toxicity of the anti-TB drugs rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) either alon... Read More about Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics.

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury (2016)
Journal Article
Osna, N., Carter, W., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., …Kharbanda, K. (2016). Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22(27), 6192-6200. https://doi.org/10.3748/wjg.v22.i27.6192

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cel... Read More about Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury (2016)
Journal Article
Carter, W., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., …Kharbanda, K. (2016). Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Biochemical and Biophysical Research Communications, 458(3), https://doi.org/10.1016/j.bbrc.2015.01.158

We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl methyltransferase (PIMT), an enzyme that triggers repair of isoaspartate protein damage. To furt... Read More about Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.

Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms (2013)
Journal Article
Vigneswara, V., Cass, S., Wayne, D., Bolt, E. L., Ray, D. E., & Carter, W. (2013). Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms. PLoS ONE, 8(4), Article e61442. https://doi.org/10.1371/journal.pone.0061442

Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of t... Read More about Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms.

Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides (2008)
Journal Article
Tarhoni, M. H., Lister, T., Ray, D. E., & Carter, W. G. (2008). Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers, 13(4), https://doi.org/10.1080/13547500801973563

We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylcholinesterase (AChE) inhibition. Rat or human plasma... Read More about Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides.