Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, Natalie; Carter, Wayne; Ganesan, Murali; Kirpich, Irina A.; McClain, Criag J.; Petersen, Dennis R.; Shearn, Colin T.; Tomasi, Maria L.; Kharbanda, Kusum

Abstract

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

Citation

Osna, N., Carter, W., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L., & Kharbanda, K. (2016). Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22(27), 6192-6200. https://doi.org/10.3748/wjg.v22.i27.6192

• Journal Article Type: Article
• Acceptance Date: Jun 15, 2016
• Publication Date: Jun 21, 2016
• Deposit Date: Dec 5, 2016
• Publicly Available Date: Dec 5, 2016
• Journal: World Journal of Gastroenterology
• Print ISSN: 1007-9327
• Electronic ISSN: 2219-2840
• Publisher: Baishideng Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 27
• Pages: 6192-6200
• DOI: https://doi.org/10.3748/wjg.v22.i27.6192
• Keywords: Alcohol; Acetylation; Liver; Carbonylation; methylation; Dysfunction; Methylation; Glycosylation;; Phosphorylation; Ubiquitination; Sumoylation; Betaine;; Post-translational protein modification
• Public URL: https://nottingham-repository.worktribe.com/output/794138
• Publisher URL: http://www.wjgnet.com/1007-9327/full/v22/i27/6192.htm
• Contract Date: Dec 5, 2016