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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, Natalie; Carter, Wayne; Ganesan, Murali; Kirpich, Irina A.; McClain, Criag J.; Petersen, Dennis R.; Shearn, Colin T.; Tomasi, Maria L.; Kharbanda, Kusum

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Authors

Natalie Osna

Murali Ganesan

Irina A. Kirpich

Criag J. McClain

Dennis R. Petersen

Colin T. Shearn

Maria L. Tomasi

Kusum Kharbanda



Abstract

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

Citation

Osna, N., Carter, W., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., …Kharbanda, K. (2016). Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22(27), 6192-6200. https://doi.org/10.3748/wjg.v22.i27.6192

Journal Article Type Article
Acceptance Date Jun 15, 2016
Publication Date Jun 21, 2016
Deposit Date Dec 5, 2016
Publicly Available Date Mar 28, 2024
Journal World Journal of Gastroenterology
Print ISSN 1007-9327
Electronic ISSN 2219-2840
Publisher Baishideng Publishing Group
Peer Reviewed Peer Reviewed
Volume 22
Issue 27
Pages 6192-6200
DOI https://doi.org/10.3748/wjg.v22.i27.6192
Keywords Alcohol; Acetylation; Liver; Carbonylation
methylation; Dysfunction; Methylation; Glycosylation;
Phosphorylation; Ubiquitination; Sumoylation; Betaine;
Post-translational protein modification
Public URL https://nottingham-repository.worktribe.com/output/794138
Publisher URL http://www.wjgnet.com/1007-9327/full/v22/i27/6192.htm

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