All Outputs (12)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors (2020)
Journal Article
Greco, C., Catania, R., Balacco, D. L., Taresco, V., Musumeci, F., Alexander, C., …Schenone, S. (2020). Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors. Molecules, 25(22), Article 5354. https://doi.org/10.3390/molecules25225354

Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attracti... Read More about Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors.

Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances (2020)
Journal Article
Phan, H., Taresco, V., Penelle, J., & Couturaud, B. (2021). Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances. Biomaterials Science, 9(1), 38-50. https://doi.org/10.1039/d0bm01406k

Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, the presence of redox agents, and temperature. The formulation... Read More about Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances.

Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours (2020)
Journal Article
McCrorie, P., Mistry, J., Taresco, V., Lovato, T., Fay, M., Ward, I., …Rahman, R. (2020). Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours. European Journal of Pharmaceutics and Biopharmaceutics, 157, 108-120. https://doi.org/10.1016/j.ejpb.2020.10.005

Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu... Read More about Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours.

On-line polymerisation monitoring in scCO2: a reliable and inexpensive sampling method in high pressure applications (2020)
Journal Article
Kortsen, K., Pacheco, A. A., Lentz, J. C., Taresco, V., & Howdle, S. M. (2021). On-line polymerisation monitoring in scCO2: a reliable and inexpensive sampling method in high pressure applications. Journal of Supercritical Fluids, 167, Article 105047. https://doi.org/10.1016/j.supflu.2020.105047

A versatile and reliable on-line sampling system for polymerisation reactions in supercritical fluids was developed. By withdrawing a small volume of a high-pressure reaction mixture and expanding it in a controlled volume, reliable kinetic data were... Read More about On-line polymerisation monitoring in scCO2: a reliable and inexpensive sampling method in high pressure applications.

Functional initiators for the ring‐opening polymerization of polyesters and polycarbonates: An overview (2020)
Journal Article
Phan, H., Kortsen, K., Englezou, G., Couturaud, B., Nedoma, A. J., Pearce, A. K., & Taresco, V. (2020). Functional initiators for the ring‐opening polymerization of polyesters and polycarbonates: An overview. Journal of Polymer Science, 58(14), 1911-1923. https://doi.org/10.1002/pol.20200313

Functional ring-opening polymerization (ROP) initiators can instill a wide array of chemical, physical, and biological effects into a polymeric chain. Highlighting the versatility of this “active” initiator approach, a broad range of characteristics... Read More about Functional initiators for the ring‐opening polymerization of polyesters and polycarbonates: An overview.

Synthesis of two-phase polymer particles in supercritical carbon dioxide (2020)
Journal Article
Haddleton, A., Bennett, T. M., Chen, X., Atkinson, R. L., Taresco, V., & Howdle, S. M. (2020). Synthesis of two-phase polymer particles in supercritical carbon dioxide. Polymer Chemistry, 11(31), 5029-5039. https://doi.org/10.1039/d0py00729c

The synthesis of particles with discrete phases using traditional emulsion polymerisation is a well-established process. Phase-separated particles have a wide range of applications, such as in coatings, drug delivery, impact modification and as suppo... Read More about Synthesis of two-phase polymer particles in supercritical carbon dioxide.

Nanoformulation-by-design: an experimental and molecular dynamics study for polymer coated drug nanoparticles (2020)
Journal Article
Styliari, I. D., Taresco, V., Theophilus, A., Alexander, C., Garnett, M., & Laughton, C. (2020). Nanoformulation-by-design: an experimental and molecular dynamics study for polymer coated drug nanoparticles. RSC Advances, 10(33), 19521-19533. https://doi.org/10.1039/d0ra00408a

© The Royal Society of Chemistry 2020. The formulation of drug compounds into nanoparticles has many potential advantages in enhancing bioavailability and improving therapeutic efficacy. However, few drug molecules will assemble into stable, well-def... Read More about Nanoformulation-by-design: an experimental and molecular dynamics study for polymer coated drug nanoparticles.

2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations (2020)
Journal Article
Englezou, G., Kortsen, K., Pacheco, A. A. C., Cavanagh, R., Lentz, J. C., Krumins, E., …Taresco, V. (2020). 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations. Journal of Polymer Science, 58(11), 1571-1581. https://doi.org/10.1002/pol.20200183

2‐methyltetrahydrofuran (2‐MeTHF) is a readily available, inexpensive, neoteric, bio‐based solvent. It has been adopted across a wide range of chemical processes including the batch manufacture of fine chemicals, enzymatic polycondensations and ring... Read More about 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations.

Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery (2020)
Journal Article
Al-Natour, M. A., Yousif, M. D., Cavanagh, R., Abouselo, A., Apebende, E. A., Ghaemmaghami, A., …Alexander, C. (2020). Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery. ACS Macro Letters, 9(3), 431-437. https://doi.org/10.1021/acsmacrolett.9b01014

Copyright © 2020 American Chemical Society. Poly(lactic-co-glycolic acid) (PLGA) is a versatile synthetic copolymer that is widely used in pharmaceutical applications. This is because it is well-tolerated in the body, and copolymers of varying physic... Read More about Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery.

Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme (2020)
Journal Article
Greco, C., Taresco, V., Pearce, A. K., Vasey, C. E., Smith, S., Rahman, R., …Schenone, S. (2020). Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme. ACS Medicinal Chemistry Letters, 11(5), 657-663. https://doi.org/10.1021/acsmedchemlett.9b00530

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor. Residual cells at the tumor margin are responsible for up to 85% of GBM recurrences after standard treatment. Despite this evidence, the identification of compounds active on t... Read More about Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme.

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device (2020)
Journal Article
Vestri, A., Pearce, A. K., Cavanagh, R., Styliari, I. D., Sanders, C., Couturaud, B., …Sagnelli, D. (2020). Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device. Coatings, 10(2), Article 125. https://doi.org/10.3390/coatings10020125

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsul... Read More about Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device.

Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2) (2020)
Journal Article
d’Almeida Gamiero, M., Goddard, A. . R., Taresco, V., & Howdle, S. M. (2020). Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2). Green Chemistry, 22(4), 1308-1318. https://doi.org/10.1039/c9gc04011k

We seek to expand the opportunities to exploit glycerol, a largely untapped renewable feedstock, by exploiting enzymatic catalysis in supercritical carbon dioxide (scCO2). This work highlights a promising and clean approach to bio-renewable amphiphil... Read More about Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2).