All Outputs (7)

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide (2019)
Journal Article
Sodano, F., Cavanagh, R., Pearce, A. K., Lazzarato, L., Rolando, B., Fraix, A., …Sortino, S. (2020). Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide. Biomaterials Science, 8(5), 1329-1344. https://doi.org/10.1039/c9bm01644a

© 2020 The Royal Society of Chemistry. Combinations of conventional chemotherapeutics with unconventional anticancer agents such as reactive oxygen and nitrogen species may offer treatment benefits for cancer therapies. Here we report a novel polymer... Read More about Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide.

A simple and efficient method for polymer coating of iron oxide nanoparticles (2019)
Journal Article
Abushrida, A., Elhuni, I., Taresco, V., Marciani, L., Stolnik, S., & Garnett, M. C. (2020). A simple and efficient method for polymer coating of iron oxide nanoparticles. Journal of Drug Delivery Science and Technology, 55, Article 101460. https://doi.org/10.1016/j.jddst.2019.101460

Iron oxide nanoparticles (IONP) have many possible uses including as MRI contrast agents, for drug delivery and cell labelling, but need to be stabilised and to be rendered biocompatible through appropriate coatings. Many current coatings are subopti... Read More about A simple and efficient method for polymer coating of iron oxide nanoparticles.

Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites (2019)
Journal Article
Francolini, I., Taresco, V., Martinelli, A., & Piozzi, A. (2020). Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites. Enzyme and Microbial Technology, 132, Article 109439. https://doi.org/10.1016/j.enzmictec.2019.109439

Lipase-immobilized nanomaterials with high activity and stable reusability would have a great impact in different fields. However, developing such materials has proven to be challenging. Herein, polymer (pAcDED)-coated magnetic nanoparticles (MNPs) d... Read More about Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites.

Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update (2019)
Journal Article
Swainson, S. M., Styliari, I. D., Taresco, V., & Garnett, M. C. (2019). Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers, 11(10), 1561. https://doi.org/10.3390/polym11101561

The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile “polymeric-tool” in the broad field of drug delivery. The step-growth po... Read More about Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update.

Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments (2019)
Journal Article
Phan, H., Minut, R. I., McCrorie, P., Vasey, C., Larder, R. R., Krumins, E., …Pearce, A. K. (2019). Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments. Journal of Polymer Science Part A: Polymer Chemistry, 57(17), 1801-1810. https://doi.org/10.1002/pola.29451

The production of well-defined and reproducible poly-meric nanoparticles (NPs), in terms of size and stability in biological environments, is undoubtedly a fundamental challenge in the formulation of novel and more effective nanomedicines. The adopti... Read More about Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments.

Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials (2019)
Journal Article
Sagnelli, Cavanagh, Xu, Swainson, Blennow, Duncan, …Howdle. (2019). Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials. Coatings, 9(8), Article 482. https://doi.org/10.3390/coatings9080482

Starch is one of the most abundant polysaccharides on the earth and it is the most important source of energy intake for humans. Thermoplastic starch (TPS) is also widely used for new bio-based materials. The blending of starch with other molecules m... Read More about Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials.

Penetration and uptake of Nanoparticles in 3D tumour spheroids (2019)
Journal Article
Tchoryk, A., Taresco, V., Argent, R., Ashford, M. B., Gellert, P., Stolnik, S., …Garnett, M. C. (2019). Penetration and uptake of Nanoparticles in 3D tumour spheroids. Bioconjugate Chemistry, 30(5), 1371-1384. https://doi.org/10.1021/acs.bioconjchem.9b00136

Animal models are effective for assessing tumour localisation of nanosystems, but difficult to use for studying penetration beyond the vasculature. Here, we have used well-characterised HCT116 colorectal cancer spheroids to study the effect of nanopa... Read More about Penetration and uptake of Nanoparticles in 3D tumour spheroids.