All Outputs (7)

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models (2017)
Journal Article
Koch, S., Mueller, S., Foddis, M., Bienert, T., von Elverfeldt, D., Knab, F., …Boehm-Sturm, P. (in press). Atlas registration for edema-corrected MRI lesion volume in mouse stroke models. Journal of Cerebral Blood Flow and Metabolism, https://doi.org/10.1177/0271678X17726635

Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a mathematical framework to correct lesion size for edema which is based on manual delineation of the... Read More about Atlas registration for edema-corrected MRI lesion volume in mouse stroke models.

The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) (2017)
Journal Article
Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V., Deuchar, G. A., Farr, T. D., …Macrae, I. M. (in press). The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of Cerebral Blood Flow and Metabolism, https://doi.org/10.1177/0271678X17709185

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and ani... Read More about The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

Infections up to 76 days after stroke increase disability and death (2017)
Journal Article
Learoyd, A., Woodhouse, L. J., Shaw, L., Sprigg, N., Bereczki, D., Berge, E., …Trueman, R. C. (in press). Infections up to 76 days after stroke increase disability and death. Translational Stroke Research, https://doi.org/10.1007/s12975-017-0553-3

Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke... Read More about Infections up to 76 days after stroke increase disability and death.

Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment (2017)
Journal Article
Dam, K., Füchtemeier, M., Farr, T. D., Boehm-Sturm, P., Foddis, M., Dirnagl, U., …Jadavji, N. M. (2017). Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 321, https://doi.org/10.1016/j.bbr.2016.12.041

Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic(methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levelsof homocysteine. Clinical studies have shown... Read More about Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment.

Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment (2017)
Journal Article
Boehm-Sturm, P., Füchtemeier, M., Foddis, M., Mueller, S., Trueman, R. C., Zille, M., …Farr, T. D. (in press). Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment. Stroke, 48(1), https://doi.org/10.1161/STROKEAHA.116.014394

Background and Purpose�Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter damage. Although this model has attracted attention, our group has struggled to generate a re... Read More about Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment.

Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke (2017)
Journal Article
Ahmed, J., Dwyer, D. E., Farr, T. D., Harrison, D. J., Dunnett, S. B., & Trueman, R. C. (in press). Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow and Metabolism, 37(3), https://doi.org/10.1177/0271678X16684141

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimoto... Read More about Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke.

Recent progress in translational research on neurovascular and neurodegenerative disorders (2017)
Journal Article
Demuth, H.-U., Dijkhuizen, R. M., Farr, T. D., Gelderblom, M., Horsburgh, K., Iadecola, C., …Boltze, J. (2017). Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35(1), https://doi.org/10.3233/RNN-160690

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundament... Read More about Recent progress in translational research on neurovascular and neurodegenerative disorders.