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Recent progress in translational research on neurovascular and neurodegenerative disorders

Demuth, Hans-Ulrich; Dijkhuizen, Rick M.; Farr, Tracy D.; Gelderblom, Mathias; Horsburgh, Karen; Iadecola, Constantino; Mcleod, Damian D.; Michalski, Dominik; Murphy, Tim H.; Orbe, Josuna; Otte, Willem M.; Petzold, Gabor C.; Plesnila, Nikolaus; Reiser, Georg; Reymann, Klaus G.; Rueger, Maria A.; Saur, Dorothee; Savitz, Sean I.; Schilling, Stephan; Spratt, Neil J.; Turner, Renée J.; Vemuganti, Raghu; Vivien, Denis; Yepes, Manuel; Zille, Marietta; Boltze, Johannes

Authors

Hans-Ulrich Demuth

Rick M. Dijkhuizen

Tracy D. Farr

Mathias Gelderblom

Karen Horsburgh

Constantino Iadecola

Damian D. Mcleod

Dominik Michalski

Tim H. Murphy

Josuna Orbe

Willem M. Otte

Gabor C. Petzold

Nikolaus Plesnila

Georg Reiser

Klaus G. Reymann

Maria A. Rueger

Dorothee Saur

Sean I. Savitz

Stephan Schilling

Neil J. Spratt

Renée J. Turner

Raghu Vemuganti

Denis Vivien

Manuel Yepes

Marietta Zille

Johannes Boltze



Abstract

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.
This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.

Journal Article Type Article
Publication Date Jan 31, 2017
Journal Restorative Neurology and Neuroscience
Print ISSN 0922-6028
Electronic ISSN 1878-3627
Publisher IOS Press
Peer Reviewed Peer Reviewed
Volume 35
Issue 1
APA6 Citation Demuth, H., Dijkhuizen, R. M., Farr, T. D., Gelderblom, M., Horsburgh, K., Iadecola, C., …Boltze, J. (2017). Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35(1), https://doi.org/10.3233/RNN-160690
DOI https://doi.org/10.3233/RNN-160690
Keywords Alzheimer’s disease, brain, cerebral ischemia, cerebral small vessel disease, dementia, experimental therapy, hemorrhage, in vivo imaging, neuroimmunology, neuroprotection, neurorepair, sex differences, stroke, translational research, vascular cognitive i
Publisher URL http://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn160690
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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