All Outputs (84)

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, 60(12), 5785-5794. https://doi.org/10.1093/rheumatology/keab254

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation (2020)
Journal Article
Knight, H., Harman, D., Morling, J. R., Aithal, G., Card, T., Guha, I. N., & Bains, M. (2020). Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation. BMJ Open, 10(11), Article e041574. https://doi.org/10.1136/bmjopen-2020-041574

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. OBJECTIVES: The increasing incidence of chronic liver disease (CLD) in the UK may be attributed to a rise in... Read More about Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation.

Disease activity in inflammatory bowel disease is associated with arterial vascular disease (2020)
Journal Article
Card, T. R., Zittan, E., Nguyen, G. C., & Grainge, M. J. (2021). Disease activity in inflammatory bowel disease is associated with arterial vascular disease. Inflammatory Bowel Diseases, 27(5), 629–638. https://doi.org/10.1093/ibd/izaa156

Background and Aims: There is evidence that several inflammatory diseases are associated with increased cardiovascular risk. Whether this is true for inflammatory bowel diseases remains controversial. We aimed to assess this risk corrected for the ef... Read More about Disease activity in inflammatory bowel disease is associated with arterial vascular disease.

Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study (2020)
Journal Article
Grønbæk, L., Otete, H., Ban, L., Crooks, C., Card, T., Jepsen, P., & West, J. (2020). Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study. Liver International, 40(7), 1634-1644. https://doi.org/10.1111/liv.14480

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background & Aims: There are few population-based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not... Read More about Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study.

Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy (2020)
Journal Article
Beg, S., Wronska, E., Araujo, I., González Suárez, B., Ivanova, E., Fedorov, E., …Ragunath, K. (2020). Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy. Gastrointestinal Endoscopy, 91(6), 1322-1327. https://doi.org/10.1016/j.gie.2020.01.026

Backgrounds and aims: A typical capsule endoscopy (CE) case generates tens of thousands of images, with abnormalities often confined to a just few frames. Omni Mode is a novel EndoCapsule software algorithm (Olympus, Tokyo, Japan) that proposes to... Read More about Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy.

Diagnosing dysplasia in Barrett’s oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett’s dysplasia database. (2019)
Journal Article
Nachiappan, A., Ragunath, K., Card, T., & Kaye, P. (2019). Diagnosing dysplasia in Barrett’s oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett’s dysplasia database. Scandinavian Journal of Gastroenterology, 55(1), 9-13. https://doi.org/10.1080/00365521.2019.1706762

Objectives: The role of random, four-quadrant biopsy (i.e. systematic biopsy) in Barrett’s oesophagus surveillance has been questioned given its drawbacks and the emergence of high-resolution endoscopy and advanced imaging modalities. Our study aims... Read More about Diagnosing dysplasia in Barrett’s oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett’s dysplasia database..

Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data (2019)
Journal Article
Card, T., Ungaro, R., Bhayat, F., Blake, A., Hantsbarger, G., & Travis, S. (2020). Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data. Alimentary Pharmacology and Therapeutics, 51(1), 149-157. https://doi.org/10.1111/apt.15538

© 2019 John Wiley & Sons Ltd Background: Vedolizumab is a gut-selective antibody to α4β7integrin approved to treat moderate-to-severe Crohn's disease and ulcerative colitis in adults. Inflammatory bowel disease (IBD) and immunosuppressant use are a... Read More about Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data.

Diagnosis of Barrett’s esophagus and Esophageal Varices using a Magnetically Assisted Capsule Endoscopy system (2019)
Journal Article
Beg, S., Card, T., Warburton, S., Rahman, I., Wilkes, E., White, J., & Ragunath, K. (2020). Diagnosis of Barrett’s esophagus and Esophageal Varices using a Magnetically Assisted Capsule Endoscopy system. Gastrointestinal Endoscopy, 91(4), 773-781.e1. https://doi.org/10.1016/j.gie.2019.10.031

Background and Aims
Magnetically assisted capsule endoscopy (MACE) potentially offers a comfortable, patient friendly, and community-based alternative to gastroscopy (EGD). This pilot study aims to explore whether this approach can be used to accura... Read More about Diagnosis of Barrett’s esophagus and Esophageal Varices using a Magnetically Assisted Capsule Endoscopy system.

Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort (2018)
Journal Article
Quarpong, W., Card, T. R., West, J., Solaymani-Dodaran, M., Logan, R. F., & Grainge, M. J. (2019). Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort. United European Gastroenterology Journal, 7(3), 377-387. https://doi.org/10.1177/2050640618814662

Background: Few studies have determined the very long-term mortality risks in adult and childhood-diagnosed coeliac disease.

Objective: We quantified mortality risks in coeliac disease and determined whether age at diagnosis, or time following di... Read More about Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort.

The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity (2018)
Journal Article
Chu, T. P. C., Grainge, M. J., & Card, T. R. (2018). The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity. Alimentary Pharmacology and Therapeutics, 48(10), 1099-1108. https://doi.org/10.1111/apt.15010

Background: Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism.
Aim: To determine when patients are at high risk of thromboembolic events, including after major surgery, and to guide timing of thromboprophylaxis.
Methods:... Read More about The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity.

All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis (2018)
Journal Article
Abdul-Rahman, A.-K., Card, T. R., Grainge, M. J., & Fleming, K. M. (2018). All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis. Substance Abuse, 39(4), 509-517. https://doi.org/10.1080/08897077.2018.1475318

Background
Although alcohol use disorders (AUD) are known to increase the relative risk of all-cause and some cause-specific mortalities, the absolute mortality rates of the AUD population are unknown. Such knowledge would benefit planners of the pr... Read More about All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis.

Post infectious IBS: defining its clinical features and prognosis using an internet-based survey (2018)
Journal Article
Card, T., Enck, P., Barbara, G., Boeckxstaens, G. E., Santos, J., Azpiroz, F., Mearin, F., Aziz, Q., Marshall, J., & Spiller, R. C. (2018). Post infectious IBS: defining its clinical features and prognosis using an internet-based survey. United European Gastroenterology Journal, 6(8), 1245-1253. https://doi.org/10.1177/2050640618779923

Background: Gastrointestinal infection is an important risk factor for developing IBS. Our aim was to characterise postinfectious IBS (PI-IBS) compared to other IBS patients.
Methods: An internet survey of IBS patients using Rome III diagnostic ques... Read More about Post infectious IBS: defining its clinical features and prognosis using an internet-based survey.

Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data (2018)
Journal Article
Otete, H. E., Deleuran, T., Fleming, K. M., Card, T. R., Aithal, G. P., Jepsen, P., & West, J. (2018). Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data. Journal of Hepatology, 69(3), 697-704. https://doi.org/10.1016/j.jhep.2018.04.002

Background & aims: Cirrhosis is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with alcoholic cirrhosis. Using linked primary and secondary care data from the English and Danish... Read More about Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data.

What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab? (2018)
Journal Article
Card, T. R., Xu, J., Liang, H., & Bhayat, F. (2018). What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab?. Inflammatory Bowel Diseases, 24(5), https://doi.org/10.1093/ibd/izx097

Background: Progressive multifocal leukoencephalopathy is a serious condition linked to certain diseases and immunosuppressant therapies, including the α4 integrin antagonist natalizumab. No cases have been reported to date with vedolizumab, a select... Read More about What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab?.

Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography (2017)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Wilkes, E. A., Card, T. R., Aithal, G. P., & Guha, I. N. (2018). Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography. Alimentary Pharmacology and Therapeutics, 47(4), 504-515. https://doi.org/10.1111/apt.14463

Background: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as type 2 diabetes and obesity may also be important.
Aim: To screen at-... Read More about Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography.

Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis (2017)
Journal Article
Khan, U. T., Walker, A. J., Baig, S., Card, T. R., Kirwan, C. C., & Grainge, M. J. (2017). Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis. BMC Cancer, 17(747), https://doi.org/10.1186/s12885-017-3719-1

Background
Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in breast cancer patients is conflicting. We present data from a large cohort of... Read More about Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis.

The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database. (2017)
Journal Article
Othman, F., Crooks, C. J., & Card, T. R. (in press). The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database. United European Gastroenterology Journal, https://doi.org/10.1177/2050640617695697

Background: Studies have found an association between proton pump inhibitor (PPI) use and Clostridium difficile infection. The purpose of this study was to determine whether the mechanism by which PPIs induce an increased risk of C. difficile infecti... Read More about The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database..

Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article
West, J., Card, T. R., Aithal, G. P., & Fleming, K. M. (2017). Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. Alimentary Pharmacology and Therapeutics, 45(7), 983-990. https://doi.org/10.1111/apt.13961

Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC.
Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.

Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study (2016)
Journal Article
Othman, F., Crooks, C. J., & Card, T. R. (2016). Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study. BMJ, 355, Article i5813. https://doi.org/10.1136/bmj.i5813

Objective
To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association.
Design
Cohort study and self controlled case series.
S... Read More about Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study.

Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England (2016)
Journal Article
England. British Journal of Cancer, 115(7), https://doi.org/10.1038/bjc.2016.250

Background: More than 20% of colorectal cancers are diagnosed following an emergency presentation. We aimed to examine pre-diagnostic primary care consultations and related symptoms comparing patients diagnosed as emergencies with those diagnosed thr... Read More about Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England.