Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis

Hasanaj, Arbi; Zaki, Faaris; Harman, Karen E.; Grindlay, Douglas; Gran, S.

doi:10.1111/bjd.20759

Incidence rates of bullous pemphigoid, herpes zoster, and urticaria following the start of the COVID-19 vaccination programme in the UK: a population-based cohort study (2025)
Journal Article
Swiderski, M., Lewis, S., Vinogradova, Y., Ridd, M. J., Yiu, Z. Z. N., Lloyd-Lavery, A., Prasad, V., & Gran, S. (2025). Incidence rates of bullous pemphigoid, herpes zoster, and urticaria following the start of the COVID-19 vaccination programme in the UK: a population-based cohort study. British Journal of Dermatology, https://doi.org/10.1093/bjd/ljaf237

Background

Several population-based studies have reported an increased risk of serious skin conditions following COVID-19 vaccinations, but their population samples were not representative. Accurately estimating these risks is important for infor... Read More about Incidence rates of bullous pemphigoid, herpes zoster, and urticaria following the start of the COVID-19 vaccination programme in the UK: a population-based cohort study.

Skin cancers are the most common cancer in England (2025)
Journal Article
van Bodegraven, B., Ahmed, S., Ardern-Jones, M., Gran, S., Harwood, C., Millington, G., Mistry, K., Proby, C., Vernon, S., & Venables, Z. C. (in press). Skin cancers are the most common cancer in England. Clinical and Experimental Dermatology, https://doi.org/10.1093/ced/llaf163

Dear Editor, When asking a search engine, ‘What is the most common cancer in England?’ all the top results give an answer that excludes keratinocyte cancers (KCs), which is the group term for basal cell carcinomas (BCCs) and cutaneous squamous cell c... Read More about Skin cancers are the most common cancer in England.

The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study (2024)
Journal Article
Swiderski, M., Vinogradova, Y., Knaggs, R. D., Harman, K., Harwood, R. H., Prasad, V., Persson, M. S. M., Figueredo, G., Layfield, C., & Gran, S. (2025). The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study. British Journal of Dermatology, 192(3), 440-449. https://doi.org/10.1093/bjd/ljae416

Background
Bullous pemphigoid (BP) is an autoimmune skin disease that affects mainly older people. Numerous drugs have been previously associated with BP based on case series and small hospital-based studies. More reliable and precise estimates of a... Read More about The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study.

Expert opinion on characteristics of vulval lichen sclerosus: initial identification of important clinical features through an international electronic Delphi consensus study (2024)
Journal Article
Simpson, R. C., Birchall, M., Daniels, J., Gran, S., Kirtschig, G., & Thomas, K. S. (2025). Expert opinion on characteristics of vulval lichen sclerosus: initial identification of important clinical features through an international electronic Delphi consensus study. Clinical and Experimental Dermatology, 50(3), 590-596. https://doi.org/10.1093/ced/llae393

Background Lichen sclerosus (LS) is a chronic inflammatory condition that mainly affects genital skin. It causes distressing symptoms that impact daily quality of life, as well as progressive anatomical changes and a potential risk of cancer. Vulval... Read More about Expert opinion on characteristics of vulval lichen sclerosus: initial identification of important clinical features through an international electronic Delphi consensus study.

Association between prescribed oral antidiabetic medication for type 2 diabetes mellitus and risk of skin cancer: a systematic review and meta-analysis (2024)
Journal Article
Simpson, C., Leducq, S., Venables, Z., Yiu, Z. Z., Rhodes, L. E., Idris, I., & Gran, S. (2024). Association between prescribed oral antidiabetic medication for type 2 diabetes mellitus and risk of skin cancer: a systematic review and meta-analysis. British Journal of Dermatology, 192(1), 165-167. https://doi.org/10.1093/bjd/ljae341

P078 Establishing diagnostic criteria for vulval lichen sclerosus (SHELLS): an international electronic-Delphi consensus study (2024)
Journal Article
Simpson, R., Birchall, M., Daniels, J., Gran, S., Kirtschig, G., & Thomas, K. (2024). P078 Establishing diagnostic criteria for vulval lichen sclerosus (SHELLS): an international electronic-Delphi consensus study. British Journal of Dermatology, 191(Supplement_1), i51-i51. https://doi.org/10.1093/bjd/ljae090.105

Lichen sclerosus (LS) is a chronic inflammatory condition mainly affecting genital skin. It causes distressing symptoms that impact daily quality of life, results in progressive anatomical changes and has a potential risk of cancer. There is no defin... Read More about P078 Establishing diagnostic criteria for vulval lichen sclerosus (SHELLS): an international electronic-Delphi consensus study.

“Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database” (2024)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2024). “Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database”. Journal of Evaluation in Clinical Practice, 30(7), 1429-1435. https://doi.org/10.1111/jep.14045

Background

Electronic health records (EHR) are frequently used for epidemiological research including drug utilisation studies in a defined population such as the population with knee osteoarthritis (KOA). We sought to describe the process of defi... Read More about “Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database”.

Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis (2024)
Journal Article
Fathima, S., Grainge, M. J., Wainman, H., Swiderski, M., & Gran, S. (2024). Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis. Clinical and Experimental Dermatology, 49(12), 1699-1704. https://doi.org/10.1093/ced/llae183

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN), following drug administration. The study protocol was registered on PROSPERO. The Preferred Reportin... Read More about Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis.

Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma (2024)
Journal Article
Boitor, R. A., Varma, S., Sharma, A., Odedra, S., Elsheikh, S., Eldib, K., Patel, A., Koloydenko, A., Gran, S., De Winne, K., Koljenovic, S., Williams, H. C., & Notingher, I. (2024). Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma. British Journal of Dermatology, 191(3), 428-436. https://doi.org/10.1093/bjd/ljae196

Background

Autofluorescence (AF)–Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The technology does not require tissue fixation, st... Read More about Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article
Leducq, S., Zaki, F., Hollestein, L. M., Apfelbacher, C., Ponna, N. P., Mazmudar, R., & Gran, S. (2024). The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review. Journal of Clinical Epidemiology, 170, Article 111341. https://doi.org/10.1016/j.jclinepi.2024.111341

Objectives
Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention? (2023)
Journal Article
Venables, Z. C., Gran, S., Levell, N. J., Yiu, Z. Z. N., & Proby, C. M. (2024). International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention?. Clinical and Experimental Dermatology, 49(5), 514–516. https://doi.org/10.1093/ced/llad438

005 Association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Journal Article
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., Persson, M. S. M., Figueredo, G., Layfield, C., & Gran, S. (2023). 005 Association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study. British Journal of Dermatology, 188(Supplement_4), Article ljad113.005. https://doi.org/10.1093/bjd/ljad113.005

Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease, manifested by painful itching of the skin and mucous membranes. Despite high mortality, poor quality of life and increasing incidence in older people, BP can be overlooked... Read More about 005 Association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Preprint / Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., Persson, M. S., Figueredo, G., Layfield, C., & Gran, S. The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction
Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

“Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England (2023)
Journal Article
van Bodegraven, B., Vernon, S., Eversfield, C., Board, R., Paul Craig, Gran, S., Harwood, C. A., Keohane, S., Levell, N. J., Matin, R. N., Proby, C., Rajan, N., Rous, B., Ascott, A., Millington, G. W., Venables, Z. C., & BAD-NDRS Steering Committee, B.-N. S. C. (2023). “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England. British Journal of Dermatology, 188(6), 777-784. https://doi.org/10.1093/bjd/ljad033

Background
Providing detailed skin cancer statistics, including incidence and survival, by tumour type and patient characteristics is important for up-to-date epidemiological information.

Objectives
To create a new clinically relevant consensus-... Read More about “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2023). Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data. Pain Practice, https://doi.org/10.1111/papr.13212

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., Ahmed, I., & Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

MULTIPLE ways to correct for MULTIPLE comparisons in MULTIPLE types of studies (2021)
Journal Article
Hollestein, L. M., Lo, S. N., Leonardi‐Bee, J., Rosset, S., Shomron, N., Couturier, D.-L., & Gran, S. (2021). MULTIPLE ways to correct for MULTIPLE comparisons in MULTIPLE types of studies. British Journal of Dermatology, 185(6), 1081-1083. https://doi.org/10.1111/bjd.20600

Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study) (2021)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., Abdul-Wahab, A., Bewley, A., Burrows, N., Darne, S., Gach, J. E., Katugampola, R., Jury, C. S., Kuet, K.-H., Llewellyn, J., McPherson, T., Ravenscroft, J. C., Taibjee, S., Wilkinson, C., & Thomas, K. S. (2022). Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study). British Journal of Dermatology, 186(2), 341-351. https://doi.org/10.1111/bjd.20689

Background
In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults.

Objectives
To test the diagnostic accuracy of previously agreed consensus criteria and develop... Read More about Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study).

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis (2021)
Journal Article
Hasanaj, A., Zaki, F., Harman, K. E., Grindlay, D., & Gran, S. (2022). Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis. British Journal of Dermatology, 186(2), 359-361. https://doi.org/10.1111/bjd.20759

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that ha... Read More about Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

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