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Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis (2024)
Journal Article
Fathima, S., Grainge, M. J., Wainman, H., Swiderski, M., & Gran, S. (2024). Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis. Clinical and Experimental Dermatology, https://doi.org/10.1093/ced/llae183

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN), following drug administration. The study protocol was registered on PROSPERO. The Preferred Reportin... Read More about Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis.

Diagnostic accuracy of autofluorescence -Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma (2024)
Journal Article
Boitor, R. A., Varma, S., Sharma, A., Odedra, S., Elsheikh, S., Eldib, K., …Notingher, I. (2024). Diagnostic accuracy of autofluorescence -Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma. British Journal of Dermatology, https://doi.org/10.1093/bjd/ljae196

Background Autofluorescence (AF)–Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The technology does not require tissue fixation, st... Read More about Diagnostic accuracy of autofluorescence -Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article
Leducq, S., Zaki, F., Hollestein, L. M., Apfelbacher, C., Prasanna Ponna, N., Mazmudar, R., & Gran, S. (2024). The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review. Journal of Clinical Epidemiology, 170, Article 111341. https://doi.org/10.1016/j.jclinepi.2024.111341

Objectives Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. (0000). The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

“Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England (2023)
Journal Article
van Bodegraven, B., Vernon, S., Eversfield, C., Board, R., Paul Craig, Gran, S., …BAD-NDRS Steering Committee, B. S. C. (2023). “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England. British Journal of Dermatology, 188(6), 777-784. https://doi.org/10.1093/bjd/ljad033

Background Providing detailed skin cancer statistics, including incidence and survival, by tumour type and patient characteristics is important for up-to-date epidemiological information. Objectives To create a new clinically relevant consensus-... Read More about “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2023). Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data. Pain Practice, https://doi.org/10.1111/papr.13212

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., …Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study) (2021)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., Abdul-Wahab, A., …Thomas, K. S. (2022). Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study). British Journal of Dermatology, 186(2), 341-351. https://doi.org/10.1111/bjd.20689

Background In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults. Objectives To test the diagnostic accuracy of previously agreed consensus criteria and develop... Read More about Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study).

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis (2021)
Journal Article
Hasanaj, A., Zaki, F., Harman, K. E., Grindlay, D., & Gran, S. (2022). Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis. British Journal of Dermatology, 186(2), 359-361. https://doi.org/10.1111/bjd.20759

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that ha... Read More about Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article
Persson, M. S., Harman, K. E., Thomas, K. S., Chalmers, J. R., Vinogradova, Y., Langan, S. M., …Gran, S. (2021). Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study. British Journal of General Practice, 71(713), e904-e911. https://doi.org/10.3399/BJGP.2020.0870

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

The global incidence of bullous pemphigoid: a systematic review and meta-analysis (2021)
Journal Article
Persson, M. S., Begum, N., Grainge, M. J., Harman, K. E., Grindlay, D., & Gran, S. (2022). The global incidence of bullous pemphigoid: a systematic review and meta-analysis. British Journal of Dermatology, 186(3), 414-425. https://doi.org/10.1111/bjd.20743

Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study... Read More about The global incidence of bullous pemphigoid: a systematic review and meta-analysis.

Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study (2021)
Journal Article
Kirby, L., Gran, S., Orekoya, F., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study. British Journal of Dermatology, 185(5), 1063-1065. https://doi.org/10.1111/bjd.20583

Increasing evidence suggests the pathogenesis of male genital lichen sclerosus (LS) is driven by chronic, occluded exposure of susceptible epithelium to the irritant effect of urine (1, 2). It is not clear how this can be extrapolated to females, how... Read More about Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article
Howells, L., Gran, S., Chalmers, J. R., Stuart, B., Santer, M., Bradshaw, L., …Thomas, K. S. (2021). Do patient characteristics matter when calculating sample size for eczema clinical trials?. Skin Health and Disease, 1(3), Article e42. https://doi.org/10.1002/ski2.42

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis (2021)
Journal Article
Cunliffe, A., Gran, S., Ali, U., Grindlay, D., Lax, S., Williams, H., & Burden-Teh, E. (2021). Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis. Skin Health and Disease, 1(2), Article e29. https://doi.org/10.1002/ski2.29

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis.

Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records (2021)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2021). Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records. Osteoarthritis and Cartilage, 3(2), Article 100165. https://doi.org/10.1016/j.ocarto.2021.100165

Objective To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA). Methods A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with... Read More about Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records.

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis (2021)
Journal Article
Kirby, L., Gran, S., Kreuser-Genis, I., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis. Skin Health and Disease, 1(1), Article e13. https://doi.org/10.1002/ski2.13

Background Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epith... Read More about Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis.

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England (2021)
Journal Article
Persson, M., Harman, K., Thomas, K., Chalmers, J., Vinogradova, Y., Langan, S., …Gran, S. (2021). Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England. BMC Medical Research Methodology, 21(1), Article 22. https://doi.org/10.1186/s12874-021-01212-1

Background Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size of the pool of potential part... Read More about Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England (2020)
Journal Article
Persson, M. S., Harman, K. E., Vinogradova, Y., Langan, S. M., Hippisley-Cox, J., Thomas, K. S., & Gran, S. (2020). Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England. BMJ Open, 10(7), e035934. https://doi.org/10.1136/bmjopen-2019-035934

Objectives: The validity of bullous pemphigoid and pemphigus vulgaris recording in routinely collected healthcare data in the UK is unknown. We assessed the positive predictive value (PPV) for bullous pemphigoid and pemphigus vulgaris primary care Re... Read More about Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England.