All Outputs (35)

The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study (2024)
Journal Article
Swiderski, M., Vinogradova, Y., Knaggs, R. D., Harman, K., Harwood, R. H., Prasad, V., Persson, M. S. M., Figueredo, G., Layfield, C., & Gran, S. (in press). The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study. British Journal of Dermatology, Article ljae416. https://doi.org/10.1093/bjd/ljae416

Background
Bullous pemphigoid (BP) is an autoimmune skin disease that affects mainly older people. Numerous drugs have been previously associated with BP based on case series and small hospital-based studies. More reliable and precise estimates of a... Read More about The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study.

“Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database” (2024)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2024). “Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database”. Journal of Evaluation in Clinical Practice, 30(7), 1429-1435. https://doi.org/10.1111/jep.14045

Background

Electronic health records (EHR) are frequently used for epidemiological research including drug utilisation studies in a defined population such as the population with knee osteoarthritis (KOA). We sought to describe the process of defi... Read More about “Application of five different strategies to define a cohort of patients with knee osteoarthritis in a large primary care database”.

Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis (2024)
Journal Article
Fathima, S., Grainge, M. J., Wainman, H., Swiderski, M., & Gran, S. (2024). Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis. Clinical and Experimental Dermatology, https://doi.org/10.1093/ced/llae183

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN), following drug administration. The study protocol was registered on PROSPERO. The Preferred Reportin... Read More about Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis.

Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma (2024)
Journal Article
Boitor, R. A., Varma, S., Sharma, A., Odedra, S., Elsheikh, S., Eldib, K., Patel, A., Koloydenko, A., Gran, S., De Winne, K., Koljenovic, S., Williams, H. C., & Notingher, I. (2024). Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma. British Journal of Dermatology, 191(3), 428-436. https://doi.org/10.1093/bjd/ljae196

Background

Autofluorescence (AF)–Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The technology does not require tissue fixation, st... Read More about Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article
Leducq, S., Zaki, F., Hollestein, L. M., Apfelbacher, C., Ponna, N. P., Mazmudar, R., & Gran, S. (2024). The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review. Journal of Clinical Epidemiology, 170, Article 111341. https://doi.org/10.1016/j.jclinepi.2024.111341

Objectives
Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article
Leducq, S., Zaki, F., Hollestein, L. M., Apfelbacher, C., Ponna, N. P., Mazmudar, R., & Gran, S. (2024). The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review. Journal of Clinical Epidemiology, 170, Article 111341. https://doi.org/10.1016/j.jclinepi.2024.111341

Objectives
Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention? (2023)
Journal Article
Venables, Z. C., Gran, S., Levell, N. J., Yiu, Z. Z. N., & Proby, C. M. (2024). International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention?. Clinical and Experimental Dermatology, 49(5), 514–516. https://doi.org/10.1093/ced/llad438

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Preprint / Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction
Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

“Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England (2023)
Journal Article
van Bodegraven, B., Vernon, S., Eversfield, C., Board, R., Paul Craig, Gran, S., …BAD-NDRS Steering Committee, B.-N. S. C. (2023). “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England. British Journal of Dermatology, 188(6), 777-784. https://doi.org/10.1093/bjd/ljad033

Background
Providing detailed skin cancer statistics, including incidence and survival, by tumour type and patient characteristics is important for up-to-date epidemiological information.

Objectives
To create a new clinically relevant consensus-... Read More about “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2023). Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data. Pain Practice, https://doi.org/10.1111/papr.13212

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., …Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

MULTIPLE ways to correct for MULTIPLE comparisons in MULTIPLE types of studies (2021)
Journal Article
Hollestein, L. M., Lo, S. N., Leonardi‐Bee, J., Rosset, S., Shomron, N., Couturier, D.-L., & Gran, S. (2021). MULTIPLE ways to correct for MULTIPLE comparisons in MULTIPLE types of studies. British Journal of Dermatology, 185(6), 1081-1083. https://doi.org/10.1111/bjd.20600

Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study) (2021)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., Abdul-Wahab, A., …Thomas, K. S. (2022). Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study). British Journal of Dermatology, 186(2), 341-351. https://doi.org/10.1111/bjd.20689

Background
In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults.

Objectives
To test the diagnostic accuracy of previously agreed consensus criteria and develop... Read More about Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study).

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis (2021)
Journal Article
Hasanaj, A., Zaki, F., Harman, K. E., Grindlay, D., & Gran, S. (2022). Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis. British Journal of Dermatology, 186(2), 359-361. https://doi.org/10.1111/bjd.20759

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that ha... Read More about Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article
Persson, M. S., Harman, K. E., Thomas, K. S., Chalmers, J. R., Vinogradova, Y., Langan, S. M., …Gran, S. (2021). Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study. British Journal of General Practice, 71(713), e904-e911. https://doi.org/10.3399/BJGP.2020.0870

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article
Howells, L., Gran, S., Chalmers, J. R., Stuart, B., Santer, M., Bradshaw, L., …Thomas, K. S. (2021). Do patient characteristics matter when calculating sample size for eczema clinical trials?. Skin Health and Disease, 1(3), Article e42. https://doi.org/10.1002/ski2.42

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records (2021)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2021). Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records. Osteoarthritis and Cartilage, 3(2), Article 100165. https://doi.org/10.1016/j.ocarto.2021.100165

Objective

To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA).

Methods

A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with... Read More about Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records.

A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans (2020)
Journal Article
Durack, A., Gran, S., Gardiner, M., Jain, A., Craythorne, E., Proby, C., …Matin, R. (2021). A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans. British Journal of Dermatology, 184(4), 731-739. https://doi.org/10.1111/bjd.19346

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurr... Read More about A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans.

Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics (2019)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., & Thomas, K. S. (2019). Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics. BMJ Open, 9(8), e028689. https://doi.org/10.1136/bmjopen-2018-028689

Introduction Diagnosing psoriasis in children can be challenging. Early and accurate diagnosis is important to ensure patients receive psoriasis specific treatment and monitoring. It is recognised that the physical, psychological, quality of life, fi... Read More about Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics.

Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016 (2019)
Journal Article
van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., Mureau, M. A., Williams, H., …Hollestein, L. M. (2019). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, 99(12), 1160-1165. https://doi.org/10.2340/00015555-3287

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890... Read More about Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016.