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Immunomodulators and advanced therapies for induction of remission in Crohn's disease: a systematic review and network meta-analysis (2025)
Journal Article
Radford, S., & Moran, G. (in press). Immunomodulators and advanced therapies for induction of remission in Crohn's disease: a systematic review and network meta-analysis. Inflammatory Bowel Diseases,

Background: Previous reviews for CD treatment have rarely considered advanced and immunomodulator medical therapies together. Our aim was to compare all therapies for efficacy and safety in induction of remission.
Methods: We searched databases up t... Read More about Immunomodulators and advanced therapies for induction of remission in Crohn's disease: a systematic review and network meta-analysis.

British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025 (2025)
Journal Article
Moran, G. W., Gordon, M., Sinopolou, V., Radford, S. J., Darie, A.-M., Kumar Vuyyuru, S., Alrubaiy, L., Arebi, N., Blackwell, J., Butler, T. D., Chew, T., Cooney, R., De Marco, G., Din, S., Din, S., Feakins, R., Gasparetto, M., Gordon, H., Hansen, R., Kok, K. B., …IBD guideline development group. (2025). British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025. Gut, 74(Suppl 2), s1-s101. https://doi.org/10.1136/gutjnl-2024-334395

In response to recent advancements in inflammatory bowel disease (IBD) management, the British Society of Gastroenterology (BSG) Clinical Services and Standards Committee (CSSC) has commissioned the BSG IBD section to update its guidelines, last revi... Read More about British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025.

Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions (2025)
Journal Article
Gordon, M., Shaban, N., Sinopoulou, V., Vuyyuru, S., Radford, S., Magro, F., Armuzzi, A., Peyrin-Biroulet, L., Jairath, V., & Moran, G. (2025). Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions. Inflammatory Bowel Diseases, https://doi.org/10.1093/ibd/izaf085

Background
When designing clinical trials, interpreting trial outcomes for guideline development or sharing decisions with patients in clinical practice, the clinical outcomes used and the implicit choices on what constitutes a clinically significan... Read More about Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions.

Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease (2025)
Journal Article
Noor, N. M., Radford, S. J., Choodari-Oskooei, B., Gordon, M., Hart, A. L., Hepburn, T., Juszczak, E., Lindsay, J. O., Kennedy, N. A., Parmar, M. K. B., Jairath, V., & Moran, G. W. (2025). Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease. Nature Reviews Gastroenterology and Hepatology, 22, 364-366. https://doi.org/10.1038/s41575-025-01052-0

There is emerging interest in adaptive platform trials for inflammatory bowel disease. In this Comment, we present the results of a workshop that was convened to consider the opportunities and challenges of developing a platform trial in Crohn’s dise... Read More about Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease.

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

P556 Immunomodulator and advanced therapies for Induction of clinical remission and response in Crohn’s disease: A systematic review and network meta-analysis (2024)
Journal Article
Sinopoulou, V., Gordon, M., Vuyyuru, S., Darie, A. M., Radford, S., Shale, M., & Moran, G. (2024). P556 Immunomodulator and advanced therapies for Induction of clinical remission and response in Crohn’s disease: A systematic review and network meta-analysis. Journal of Crohn's and Colitis, 18(Supplement_1), i1085. https://doi.org/10.1093/ecco-jcc/jjad212.0686

Background

Several effective advanced therapies have been approved for the treatment of Crohn’s disease (CD) in the past two decades. Many have used synthesis techniques to study this area, but these rarely consider both advanced and immunomodula... Read More about P556 Immunomodulator and advanced therapies for Induction of clinical remission and response in Crohn’s disease: A systematic review and network meta-analysis.

An examination of resting-state functional connectivity in patients with active Crohn’s disease (2023)
Journal Article
Thapaliya, G., Eldeghaidy, S., Radford, S. J., Francis, S. T., & Moran, G. W. (in press). An examination of resting-state functional connectivity in patients with active Crohn’s disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-net... Read More about An examination of resting-state functional connectivity in patients with active Crohn’s disease.

An examination of resting-state functional connectivity in patients with active Crohn's disease (2023)
Journal Article
Francis, S. T., Moran, G. W., Eldeghaidy, S., Radford, S., & Thapaliya, G. (2023). An examination of resting-state functional connectivity in patients with active Crohn's disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-net... Read More about An examination of resting-state functional connectivity in patients with active Crohn's disease.

Stepping into nursing research: an introduction for gastroenterology and hepatology nurses (2023)
Journal Article
Munnelly, S., Radford, S., Datt, P., Donnelly, L., Fraser, A., Gil-Zaragozano, E., Jack, K., Watson, H., Tariq, I., Shaji, S., & Kemp, K. (2024). Stepping into nursing research: an introduction for gastroenterology and hepatology nurses. Frontline Gastroenterology, 15(2), 137-143. https://doi.org/10.1136/flgastro-2023-102493

In this second part of an introduction to research for gastroenterology and hepatology nurses, we aim to build on the first article that introduced the significance and structure of the National Institute of Health and Care Research (NIHR) clinical r... Read More about Stepping into nursing research: an introduction for gastroenterology and hepatology nurses.

Significance and structure of clinical research in the UK: an introduction for gastroenterology and hepatology nurses (2023)
Journal Article
Olsen, B. J., Kemp, K., Campbell, R., Kumar, S., Monje-Garcia, L., Sebastian, S., Iqbal, T., & Radford, S. J. (2024). Significance and structure of clinical research in the UK: an introduction for gastroenterology and hepatology nurses. Frontline Gastroenterology, 15(2), 170-173. https://doi.org/10.1136/flgastro-2023-102492

This is the first of two articles from the joint British Society of Gastroenterology Nurses association and Research Committee working group. The group is dedicated to signposting and improving access to research for specialist nurses working in gast... Read More about Significance and structure of clinical research in the UK: an introduction for gastroenterology and hepatology nurses.

Systematic Review: Sarcopenia in paediatric inflammatory bowel disease (2023)
Journal Article
Aljilani, B., Tsintzas, K., Jacques, M., Radford, S., & Moran, G. W. (2023). Systematic Review: Sarcopenia in paediatric inflammatory bowel disease. Clinical Nutrition ESPEN, 57, 647-654. https://doi.org/10.1016/j.clnesp.2023.08.009

Background: Low skeletal muscle mass (MM) and deteriorated function (sarcopenia) can be a frequent complication in paediatric inflammatory bowel disease (IBD). Aim: To conduct a systematic review of the paediatric IBD literature on skeletal muscle fu... Read More about Systematic Review: Sarcopenia in paediatric inflammatory bowel disease.

Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study. (2023)
Journal Article
Radford, S., Leighton, P., Coad, J., & Moran, G. (2023). Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study. BMJ Open, 13(6), Article e067528. https://doi.org/10.1136/bmjopen-2022-067528

The study sought to explore and better understand the perceptions and experiences of stakeholders in relation to the use of ultrasound for the assessment of inflammatory bowel disease (IBD) in adults in the UK. A qualitative semistructured interview... Read More about Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study..

Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them (2023)
Journal Article
Kyriacou, M., Radford, S., & Moran, G. W. (2023). Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them. BMJ Open Gastroenterology, 10(1), Article e001139. https://doi.org/10.1136/bmjgast-2023-001139

Refractory ulcerative proctitis presents a huge clinical challenge not only for the patients living with this chronic, progressive condition but also for the professionals who care for them. Currently, there is limited research and evidence-based gui... Read More about Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them.

Crohn’s Disease Patient Experiences and Preferences With Disease Monitoring: An International Qualitative Study (2023)
Journal Article
Rohatinsky, N., Zelinsky, S., Dolinger, M., Christensen, B., Wilkens, R., Radford, S., Dubinsky, M., & Novak, K. (2023). Crohn’s Disease Patient Experiences and Preferences With Disease Monitoring: An International Qualitative Study. Crohn's & Colitis 360, 5(2), Article otad012. https://doi.org/10.1093/crocol/otad012

Background
Strategies incorporating objective disease monitoring in Crohn’s disease (CD), beyond clinical symptoms are important to improve patient outcomes. Little evidence exists to explore patient understanding of CD treatment goals, nor preferen... Read More about Crohn’s Disease Patient Experiences and Preferences With Disease Monitoring: An International Qualitative Study.

Investigating the Relationship between Home Parenteral Support and Needs-Based Quality of Life in Patients with Chronic Intestinal Failure: A National Multi-Centre Longitudinal Cohort Study (2023)
Journal Article
Jones, D., Lal, S., French, C., Sowerbutts, A. M., Gittins, M., Gabe, S., Brundrett, D., Culkin, A., Calvert, C., Thompson, B., Cooper, S. C., Fletcher, J., Donnellan, C., Forbes, A., Lam, C., Radford, S., Mountford, C. G., Rogers, D., Muggridge, R., Sharkey, L., …Burden, S. (2023). Investigating the Relationship between Home Parenteral Support and Needs-Based Quality of Life in Patients with Chronic Intestinal Failure: A National Multi-Centre Longitudinal Cohort Study. Nutrients, 15(3), Article 622. https://doi.org/10.3390/nu15030622

Home parenteral support (HPS) is an essential but potentially burdensome treatment that can affect quality of life (QoL). The aims of this longitudinal study were to understand whether any changes in HPS over time were associated with QoL. The Parent... Read More about Investigating the Relationship between Home Parenteral Support and Needs-Based Quality of Life in Patients with Chronic Intestinal Failure: A National Multi-Centre Longitudinal Cohort Study.

The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease (2022)
Journal Article
Thapaliya, G., Eldeghaidy, S., Asghar, M., McGing, J., Radford, S., Francis, S., & Moran, G. W. (2022). The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease. Brain Imaging and Behavior, 17(2), 149–160. https://doi.org/10.1007/s11682-022-00742-6

Alterations in grey matter volume (GMV) and cortical thickness (CT) in Crohn’s disease (CD) patients has been previously documented. However, the findings are inconsistent, and not a true representation of CD burden, as only CD patients in remission... Read More about The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease.

Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease (2022)
Journal Article
Ellul, P., Schembri, J., Vella Baldacchino, A., Molnár, T., Resal, T., Allocca, M. A., Furfaro, F., Buono, A. D., Theodoropoulou, A., Fragaki, M., Tsoukali, E., Mantzaris, G. J., Phillips, F. M., Radford, S., Moran, G., Gonzalez, H. A., Sebastian, S., Fousekis, F., Christodoulou, D., Snir, I., …Katsanos, K. (2023). Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease. Journal of Crohn's and Colitis, 17(4), 489-496. https://doi.org/10.1093/ecco-jcc/jjac169

BACKGROUND AND AIMS: Post-inflammatory polyps [PIPs] are considered as indicators of previous episodes of severe inflammation and mucosal ulceration. Inflammatory bowel disease [IBD], namely Crohn's disease [CD] and ulcerative colitis [UC], exhibit a... Read More about Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease.

The impact of Inflammatory Bowel Disease related fatigue on Health-Related Quality of Life: a qualitative semi-structured interview study (2022)
Journal Article
Radford, S. J., Moran, G. W., & Czuber-Dochan, W. (2022). The impact of Inflammatory Bowel Disease related fatigue on Health-Related Quality of Life: a qualitative semi-structured interview study. Journal of Research in Nursing, 27(8), 685-702. https://doi.org/10.1177/17449871211061048

Background: Fatigue is a frequently reported symptom of Inflammatory Bowel Disease (IBD), having a negative impact on Health-Related Quality of Life (HRQoL). Patients’ experiences of this have not been researched in IBD. Methods: Semi-structured inte... Read More about The impact of Inflammatory Bowel Disease related fatigue on Health-Related Quality of Life: a qualitative semi-structured interview study.

Imaging in inflammatory bowel disease: current and future perspectives (2022)
Journal Article
Shaban, N., Hoad, C. L., Naim, I., Alshammari, M., Radford, S. J., Clarke, C., Marciani, L., & Moran, G. (2022). Imaging in inflammatory bowel disease: current and future perspectives. Frontline Gastroenterology, 13(e1), E28-E34. https://doi.org/10.1136/flgastro-2022-102117

The use of cross-sectional imaging and ultrasonography has long complemented endoscopic assessment of inflammatory bowel disease (IBD). Clinical symptoms alone are often not enough to assess disease activity, so a reliance on non-invasive techniques... Read More about Imaging in inflammatory bowel disease: current and future perspectives.