All Outputs (20)

Reimagining Dementia Care: A Complex Intervention Systematic Review on Optimising Social Prescribing (SP) for People Living With Dementia (PLWD) in the United Kingdom (2025)
Journal Article
Papavasiliou, E., Marshall, J., Allan, L., Bradbury, K., Fox, C., Hawkes, M., Irvine, A., Moniz-Cook, E., Pick, A., Polley, M., Rathbone, A., Reeve, J., Robinson, L., Rook, G., Sadler, E., Wolverson, E., Walker, S., & Cross, J. (2025). Reimagining Dementia Care: A Complex Intervention Systematic Review on Optimising Social Prescribing (SP) for People Living With Dementia (PLWD) in the United Kingdom. Health Expectations, 28(3), Article e70289. https://doi.org/10.1111/hex.70289

Introduction
Dementia is a complex medical condition that poses significant challenges to healthcare systems and support services. People living with dementia (PLWD) often face complex needs, exacerbated by social isolation and difficulty accessing... Read More about Reimagining Dementia Care: A Complex Intervention Systematic Review on Optimising Social Prescribing (SP) for People Living With Dementia (PLWD) in the United Kingdom.

Reimagining Dementia Care: A Complex Intervention Systematic Review on Optimising Social Prescribing (SP) for Carers of People Living With Dementia (PLWD) in the United Kingdom (2025)
Journal Article
Marshall, J., Papavasiliou, E., Allan, L., Bradbury, K., Fox, C., Hawkes, M., Irvine, A., Moniz‐Cook, E., Pick, A., Polley, M., Rathbone, A., Reeve, J., Robinson, D. L., Rook, G., Sadler, E., Wolverson, E., Walker, S., & Cross, J. (2025). Reimagining Dementia Care: A Complex Intervention Systematic Review on Optimising Social Prescribing (SP) for Carers of People Living With Dementia (PLWD) in the United Kingdom. Health Expectations, 28(3), Article e70286. https://doi.org/10.1111/hex.70286

Introduction

Carers of people living with dementia (PLWD) face a range of complex needs, including medical, emotional, social and practical challenges, often exacerbated by social isolation and barriers to accessing support. Social prescribing (SP... Read More about Reimagining Dementia Care: A Complex Intervention Systematic Review on Optimising Social Prescribing (SP) for Carers of People Living With Dementia (PLWD) in the United Kingdom.

Trajectories of functional limitations, health-related quality of life and societal costs in individuals with long COVID: a population-based longitudinal cohort study (2024)
Journal Article
Wang, J., Goodfellow, H., Walker, S., Blandford, A., Pfeffer, P., R Hurst, J., Sunkersing, D., Bradbury, K., Robson, C., Henley, W., & Gomes, M. (2024). Trajectories of functional limitations, health-related quality of life and societal costs in individuals with long COVID: a population-based longitudinal cohort study. BMJ Open, 14(11), Article e088538. https://doi.org/10.1136/bmjopen-2024-088538

Objectives

To examine trajectories of functional limitations, fatigue, health-related quality of life (HRQL) and societal costs of patients referred to long COVID clinics.

Design

A population-based longitudinal cohort study using real-time... Read More about Trajectories of functional limitations, health-related quality of life and societal costs in individuals with long COVID: a population-based longitudinal cohort study.

Social prescribing for people living with dementia (PLWD) and their carers: what works, for whom, under what circumstances and why – protocol for a complex intervention systematic review (2024)
Journal Article
Marshall, J., Papavasiliou, E., Fox, C., Hawkes, M., Irvine, A., Moniz-Cook, E., Pick, A., Polley, M. J., Reeve, J., Robinson, L., Rook, G., Sadler, E., Wolverson, E., Walker, S., & Cross, J. L. (2024). Social prescribing for people living with dementia (PLWD) and their carers: what works, for whom, under what circumstances and why – protocol for a complex intervention systematic review. BMJ Open, 14(4), Article e080551. https://doi.org/10.1136/bmjopen-2023-080551

Introduction Dementia is a complex medical condition that poses significant challenges to healthcare systems and support services. People living with dementia (PLWD) and their carers experience complex needs often exacerbated by social isolation and... Read More about Social prescribing for people living with dementia (PLWD) and their carers: what works, for whom, under what circumstances and why – protocol for a complex intervention systematic review.

Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study (2023)
Journal Article
Walker, S., Goodfellow, H., Pookarnjanamorakot, P., Murray, E., Bindman, J., Blandford, A., Bradbury, K., Cooper, B., L Hamilton, F., R Hurst, J., Hylton, H., Linke, S., Pfeffer, P., Ricketts, W., Robson, C., A Stevenson, F., Sunkersing, D., Wang, J., Gomes, M., Henley, W., & With Covid Recovery Collaboration, L. (2023). Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open, 13(6), Article e069217. https://doi.org/10.1136/bmjopen-2022-069217

Objectives To describe self-reported characteristics and symptoms of treatment-seeking patients with post-COVID-19 syndrome (PCS). To assess the impact of symptoms on health-related quality of life (HRQoL) and patients’ ability to work and undertake... Read More about Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study.

A randomised controlled trial to investigate the clinical effectiveness and cost effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for depressed non-responders to Increasing Access to Psychological Therapies (IAPT) high-intensity therapies: study protocol (2023)
Journal Article
Barnhofer, T., Dunn, B. D., Strauss, C., Ruths, F., Barrett, B., Ryan, M., Ladwa, A., Stafford, F., Fichera, R., Baber, H., McGuinness, A., Metcalfe, I., Harding, D., Walker, S., Ganguli, P., Rhodes, S., Young, A., & Warren, F. (2023). A randomised controlled trial to investigate the clinical effectiveness and cost effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for depressed non-responders to Increasing Access to Psychological Therapies (IAPT) high-intensity therapies: study protocol. Trials, 24, Article 43. https://doi.org/10.1186/s13063-022-06882-w

Background: Major depression represents a pressing challenge for health care. In England, Increasing Access to Psychological Therapies (IAPT) services provide evidence-based psychological therapies in a stepped-care approach to patients with depressi... Read More about A randomised controlled trial to investigate the clinical effectiveness and cost effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for depressed non-responders to Increasing Access to Psychological Therapies (IAPT) high-intensity therapies: study protocol.

Development, deployment and evaluation of digitally enabled, remote, supported rehabilitation for people with long COVID-19 (Living With COVID-19 Recovery): protocol for a mixed-methods study (2022)
Journal Article
Murray, E., Goodfellow, H., Bindman, J., Blandford, A., Bradbury, K., Chaudhry, T., Fernandez-Reyes, D., Gomes, M., Hamilton, F. L., Heightman, M., Henley, W., Hurst, J. R., Hylton, H., Linke, S., Pfeffer, P., Ricketts, W., Robson, C., Singh, R., Stevenson, F. A., Walker, S., & Waywell, J. (2022). Development, deployment and evaluation of digitally enabled, remote, supported rehabilitation for people with long COVID-19 (Living With COVID-19 Recovery): protocol for a mixed-methods study. BMJ Open, 12(2), Article e057408. https://doi.org/10.1136/bmjopen-2021-057408

Introduction Long COVID-19 is a distressing, disabling and heterogeneous syndrome often causing severe functional impairment. Predominant symptoms include fatigue, cognitive impairment ('brain fog'), breathlessness and anxiety or depression. These sy... Read More about Development, deployment and evaluation of digitally enabled, remote, supported rehabilitation for people with long COVID-19 (Living With COVID-19 Recovery): protocol for a mixed-methods study.

Does a screening trial for spinal cord stimulation in patients with chronic pain of neuropathic origin have clinical utility and cost-effectiveness (TRIAL-STIM)? A randomised controlled trial (2020)
Journal Article
Eldabe, S., Duarte, R. V., Gulve, A., Thomson, S., Baranidharan, G., Houten, R., Jowett, S., Sandhu, H., Chadwick, R., Brookes, M., Kansal, A., Earle, J., Bell, J., Robinson, J., Walker, S., Rhodes, S., & Taylor, R. S. (2020). Does a screening trial for spinal cord stimulation in patients with chronic pain of neuropathic origin have clinical utility and cost-effectiveness (TRIAL-STIM)? A randomised controlled trial. PAIN, 161(12), 2820-2829. https://doi.org/10.1097/j.pain.0000000000001977

Spinal cord stimulation (SCS) is an established treatment of chronic neuropathic pain. Although a temporary SCS screening trial is widely used to determine whether a patient should receive permanent SCS implant, its evidence base is limited. We aimed... Read More about Does a screening trial for spinal cord stimulation in patients with chronic pain of neuropathic origin have clinical utility and cost-effectiveness (TRIAL-STIM)? A randomised controlled trial.

Exercise training for chronic heart failure (ExTraMATCH II): Why all data are not equal (2019)
Journal Article
Smart, N. A., Taylor, R., Walker, S., Warren, F., Ciani, O., Davos, C. H., & Piepoli, M. (2019). Exercise training for chronic heart failure (ExTraMATCH II): Why all data are not equal. European Journal of Preventive Cardiology, 26(11), 1229-1231. https://doi.org/10.1177/2047487318815314

We, the ExTraMATCH II collaborative, recently completed an individual patient data (IPD) meta-analysis on the effect of exercise-based cardiac rehabilitation (ExCR) on mortality and hospitalisation in patients with heart failure. This analysis consid... Read More about Exercise training for chronic heart failure (ExTraMATCH II): Why all data are not equal.

Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis (2019)
Journal Article
S Taylor, R., Walker, S., Ciani, O., Warren, F., A Smart, N., Piepoli, M., & H Davos, C. (2019). Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis. Health Technology Assessment, 23(25), https://doi.org/10.3310/hta23250

Background
Current national and international guidelines on the management of heart failure (HF) recommend exercise-based cardiac rehabilitation (ExCR), but do not differentiate this recommendation according to patient subgroups.

Objectives
(1)... Read More about Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis.

Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials (2018)
Journal Article
Taylor, R. S., Walker, S., Smart, N. A., Piepoli, M. F., Warren, F. C., Ciani, O., O'Connor, C., Whellan, D., Keteyian, S. J., Coats, A., Davos, C. H., Dalal, H. M., Dracup, K., Evangelista, L., Jolly, K., Myers, J., McKelvie, R. S., Nilsson, B. B., Passino, C., Witham, M. D., …Zwisler, A. D. O. (2018). Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials. European Journal of Heart Failure, 20(12), 1735-1743. https://doi.org/10.1002/ejhf.1311

Aims:
To undertake an individual patient data (IPD) meta-analysis to assess the impact of exercise-based cardiac rehabilitation (ExCR) in patients with heart failure (HF) on mortality and hospitalisation, and differential effects of ExCR according... Read More about Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials.

Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: A Meta-Analysis of Randomized Controlled Trials (2018)
Journal Article
Ciani, O., Piepoli, M., Smart, N., Uddin, J., Walker, S., Warren, F. C., Zwisler, A. D., Davos, C. H., & Taylor, R. S. (2018). Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: A Meta-Analysis of Randomized Controlled Trials. JACC: Heart Failure, 6(7), 596-604. https://doi.org/10.1016/j.jchf.2018.03.017

Objectives: This study sought to validate exercise capacity (EC) as a surrogate for mortality, hospitalization, and health-related quality of life (HRQOL). Background: EC is often used as a primary outcome in exercise-based cardiac rehabilitation (CR... Read More about Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: A Meta-Analysis of Randomized Controlled Trials.

Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis (2018)
Journal Article
Taylor, R. S., Walker, S., Smart, N. A., Piepoli, M. F., Warren, F. C., Ciani, O., Whellan, D., O'Connor, C., Keteyian, S. J., Coats, A., Davos, C. H., Dalal, H. M., Dracup, K., Evangelista, L. S., Jolly, K., Myers, J., Nilsson, B. B., Passino, C., Witham, M. D., & Yeh, G. Y. (2019). Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis. Journal of the American College of Cardiology, 73(12), 1430-1443. https://doi.org/10.1016/j.jacc.2018.12.072

Background:
Previous systematic reviews have indicated that exercise-based cardiac rehabilitation (ExCR) for patients with heart failure (HF) has a beneficial effect on health-related quality-of-life (HRQoL) and exercise capacity. However, there is... Read More about Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis.

Risk of cervical cancer in symptomatic women aged ≥40 in primary care: A case–control study using electronic records (2017)
Journal Article
Walker, S., & Hamilton, W. (2017). Risk of cervical cancer in symptomatic women aged ≥40 in primary care: A case–control study using electronic records. European Journal of Cancer Care, 26(3), Article e12706. https://doi.org/10.1111/ecc.12706

There are approximately 3,000 new UK diagnoses of cervical cancer annually, with many women presenting symptomatically. We aimed to identify and quantify features of cervical cancer in primary care in a case–control study in the UK. Putative features... Read More about Risk of cervical cancer in symptomatic women aged ≥40 in primary care: A case–control study using electronic records.

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial) (2017)
Journal Article
Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Williams, H. C., Dean, T., Burrows, N. P., Pollock, I., Duley, L., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Mitchell, E. J., Cowdell, F., …MacCallum, S. (2017). Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). PLoS Medicine, 14(4), Article e1002280. https://doi.org/10.1371/journal.pmed.1002280

© 2017 Thomas et al. Background: The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to st... Read More about Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial).

Risk of breast cancer in symptomatic women in primary care: A case-control study using electronic records (2014)
Journal Article
Walker, S., Hyde, C., & Hamilton, W. (2014). Risk of breast cancer in symptomatic women in primary care: A case-control study using electronic records. British Journal of General Practice, 64(629), e788-e795. https://doi.org/10.3399/bjgp14X682873

Background Breast cancer is the most common cancer in the UK. GPs are encouraged to refer all women whose symptoms may represent cancer, rather than selecting those at highest risk.

Aim To identify and quantify features of breast cancer in primary... Read More about Risk of breast cancer in symptomatic women in primary care: A case-control study using electronic records.

Risk of uterine cancer in symptomatic women in primary care: case–control study using electronic records (2013)
Journal Article
Walker, S., Hyde, C., & Hamilton, W. (2013). Risk of uterine cancer in symptomatic women in primary care: case–control study using electronic records. British Journal of General Practice, 63(614), e643-e648. https://doi.org/10.3399/bjgp13X671632

Background: Uterine cancer is the fourth most common cancer in women in the UK, with approximately 7700 new diagnoses and 1700 deaths annually.

Aim: To identify and quantify features of uterine cancer in primary care. Design and setting: Case-con... Read More about Risk of uterine cancer in symptomatic women in primary care: case–control study using electronic records.

Risk factors for suicide in Hungary: A case-control study (2009)
Journal Article
Almasi, K., Belso, N., Kapur, N., Webb, R., Cooper, J., Hadley, S., Kerfoot, M., Dunn, G., Sotonyi, P., Rihmer, Z., & Appleby, L. (2009). Risk factors for suicide in Hungary: A case-control study. BMC Psychiatry, 9, Article 45. https://doi.org/10.1186/1471-244X-9-45

Background: Hungary previously had one of the highest suicide rates in the world, but experienced major social and economic changes from 1990 onwards. We aimed to investigate the antecedents of suicide in Hungary. We hypothesised that suicide in Hung... Read More about Risk factors for suicide in Hungary: A case-control study.

Suicidal behaviour in youths with depression treated with new-generation antidepressants: Meta-analysis (2006)
Journal Article
Dubicka, B., Hadley, S., & Roberts, C. (2006). Suicidal behaviour in youths with depression treated with new-generation antidepressants: Meta-analysis. British Journal of Psychiatry, 189(5), 393-398. https://doi.org/10.1192/bjp.bp.105.011833

Background: Concern exists that antidepressants can cause suicidality in youths with depression.

Aims: To determine the pooled risk of self-harm and suicidal behaviour from randomised trials of newer antidepressants.

Method: A meta-analysis w... Read More about Suicidal behaviour in youths with depression treated with new-generation antidepressants: Meta-analysis.

Telephone administered cognitive behaviour therapy for treatment of obsessive compulsive disorder: Randomised controlled non-inferiority trial (2006)
Journal Article
Lovell, K., Cox, D., Haddock, G., Jones, C., Raines, D., Garvey, R., Roberts, C., & Hadley, S. (2006). Telephone administered cognitive behaviour therapy for treatment of obsessive compulsive disorder: Randomised controlled non-inferiority trial. British Medical Journal, 333(7574), 883-886. https://doi.org/10.1136/bmj.38940.355602.80

Objectives: To compare the effectiveness of cognitive behaviour therapy delivered by telephone with the same therapy given face to face in the treatment of obsessive compulsive disorder.

Design: Randomised controlled non-inferiority trial.

Se... Read More about Telephone administered cognitive behaviour therapy for treatment of obsessive compulsive disorder: Randomised controlled non-inferiority trial.