All Outputs (2)

Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3 (2018)
Journal Article
Humphry, N. J., & Wheatley, S. P. (2018). Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3. Biology Open, 7(10), 037374. https://doi.org/10.1242/bio.037374

Survivin expression is pivotal to life and death at the cellular level. For
the past decade its pro-survival activity has been attributed to its
essential role in cell proliferation and its ability to inhibit apoptosis.
However, a growing body of... Read More about Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3.

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis (2018)
Journal Article
Wall, R. J., Ferguson, D. J. P., Freville, A., Franke-Fayard, B., Brady, D., Zeeshan, M., Bottrill, A. R., Wheatley, S., Fry, A. M., Janse, C. J., Yamano, H., Holder, A. A., Guttery, D. S., & Tewari, R. (in press). Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Scientific Reports, 8(1), Article 5610. https://doi.org/10.1038/s41598-018-23871-9

The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contributes to... Read More about Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.