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All Outputs (98)

Mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH): protocol for a prospective, randomised, open-label, blinded-endpoint phase IIb trial (2025)
Journal Article
Krishnan, K., Grace, E., Woodhouse, L., Roffe, C., Dawson, J., England, T. J., Hewson, D. W., Dineen, R. A., Law, Z. K., Pszczolkowski, S., Wells, K., Buck, A., Craig, J., Havard, D., Macleod, M. J., Werring, D. J., Doubal, F., Sprigg, N., & Bath, P. (2025). Mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH): protocol for a prospective, randomised, open-label, blinded-endpoint phase IIb trial. BMJ Open, 15(7), Article e103776. https://doi.org/10.1136/bmjopen-2025-103776

Background Acute intracerebral haemorrhage (ICH) is devastating with a 1 month mortality rate of ~40%. Cerebral oedema can complicate acute ICH and is associated with poor outcome. In patients with large ICH, the accompanying swelling increases mass... Read More about Mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH): protocol for a prospective, randomised, open-label, blinded-endpoint phase IIb trial.

Apparent diffusion coefficient for genetic characterisation of untreated adult gliomas: a meta-analysis stratified by methods (2025)
Journal Article
Bhatti, F., Strobel, J., Tench, C., Grech-Sollars, M., Dineen, R. A., Sollmann, N., & Thust, S. (2025). Apparent diffusion coefficient for genetic characterisation of untreated adult gliomas: a meta-analysis stratified by methods. Neuro-Oncology Advances, 7(1), Article vdaf103. https://doi.org/10.1093/noajnl/vdaf103

Background

Isocitrate dehydrogenase (IDH) mutation and chromosome 1p19q genotyping have become fundamental to the prognostic grouping of adult diffuse gliomas. Apparent diffusion coefficient (ADC) values may enable non-invasive prediction of gliom... Read More about Apparent diffusion coefficient for genetic characterisation of untreated adult gliomas: a meta-analysis stratified by methods.

Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis (2025)
Journal Article
Allen, C. M., Clarke, M. A., Pai, H. V., Cauchi, M., Hawken, J., Htet, Z. M., Allen-Philbey, K., Mohamed, B., Fitzsimmons, D., Das Nair, R., Morgan, P., Partlett, C., Dineen, R. A., Schmierer, K., Tallantyre, E. C., & Evangelou, N. (2025). Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis. Neurology Open Access, 1(2), Article e000017. https://doi.org/10.1212/WN9.0000000000000017

Background and Objectives
The central vein sign (CVS) describes the presence of venules within multiple sclerosis (MS) brain lesions, visible on T2*-weighted MRI. In the upcoming revision of the MS diagnostic criteria, the simplified “rule of 6” (i.... Read More about Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis.

T₁-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI (2025)
Journal Article
Marshall, M., Aphiwatthanasumet, K., Mougin, O., Stadelmann, C., Morgan, P. S., Dineen, R. A., Gowland, P., Evangelou, N., & Clarke, M. A. (2025). T₁-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI. Journal of Neuroimaging, 35(3), Article e70044. https://doi.org/10.1111/jon.70044

Background and Purpose:
Chronic active multiple sclerosis (MS) lesions represent a particularly destructive subset of lesions on pathology. However, their imaging correlates, including paramagnetic rim lesions (PRLs) detected on susceptibility-weig... Read More about T₁-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI.

White Matter Microstructural Alterations in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging (2025)
Journal Article
Alotaibi, A., Alqarras, M., Podlasek, A., Almanaa, A., AlTokhis, A., Aldhebaib, A., Aldebasi, B., Almutairi, M., Tench, C. R., Almanaa, M., Mohammadi-Nejad, A.-R., Constantinescu, C. S., Dineen, R. A., & Lee, S. (2025). White Matter Microstructural Alterations in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging. Medicina, 61(3), Article 455. https://doi.org/10.3390/medicina61030455

Background and objectives:

Type 2 diabetes mellitus (T2DM) affects brain white matter microstructure. While diffusion tensor imaging (DTI) has been used to study white matter abnormalities in T2DM, it lacks specificity for complex white matter tr... Read More about White Matter Microstructural Alterations in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.

Magnetic Resonance Imaging of Inner Ear and Internal Auditory Canal Structures in the Presence of a Cochlear Implant (2025)
Journal Article
Dewey, R. S., Dineen, R. A., Clemence, M., Menon, N., Bowtell, R., Boyle, P., & Hartley, D. E. H. (2025). Magnetic Resonance Imaging of Inner Ear and Internal Auditory Canal Structures in the Presence of a Cochlear Implant. Otology and Neurotology, 46(4), e105-e108. https://doi.org/10.1097/mao.0000000000004445

Objective
To determine whether the internal auditory canal (IAC) can be visualized using magnetic resonance imaging (MRI) in users of a cochlear implant (CI) model that can safely undergo MRI at 3 T.

Patients
Four normally hearing controls and... Read More about Magnetic Resonance Imaging of Inner Ear and Internal Auditory Canal Structures in the Presence of a Cochlear Implant.

Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI (2025)
Journal Article
Sundaresan, V., Zamboni, G., Dineen, R. A., Auer, D. P., Sotiropoulos, S. N., Sprigg, N., Jenkinson, M., & Griffanti, L. (2025). Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI. European Radiology Experimental, 9(1), Article 5. https://doi.org/10.1186/s41747-024-00544-z

Cerebral microbleeds (CMBs) are small, hypointense hemosiderin deposits in the brain measuring 2–10 mm in diameter. As one of the important biomarkers of small vessel disease, they have been associated with various neurodegenerative and cerebrovascul... Read More about Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI.

Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy (ProFATE): a multicentre, blinded-endpoint, randomised clinical trial (2024)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., Bhogal, P., Lynch, J., Booth, T. C., McConachie, N., Lenthall, R., Nair, S., Malik, L., Goddard, T., Carraro Do Nascimento, V., Barrett, E., Jethwa, K., Krishnan, K., Dineen, R. A., & England, T. J. (2024). Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy (ProFATE): a multicentre, blinded-endpoint, randomised clinical trial. Stroke, 56(2), 371-379. https://doi.org/10.1161/STROKEAHA.124.049715

BACKGROUND:

The effect of temporary blood flow arrest during endovascular thrombectomy for acute ischemic stroke is uncertain due to the lack of evidence from randomized controlled trials. We aimed to investigate whether temporary blood flow arre... Read More about Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy (ProFATE): a multicentre, blinded-endpoint, randomised clinical trial.

Diagnostic performance of axial T2-weighted MRI sequence for exclusion of brain tumour in paediatric patients with non-localizing symptoms (2024)
Journal Article
Gerrish, A. C., Malik, L., Swain, C., Thomas, A. G., Jaspan, T., & Dineen, R. A. (2024). Diagnostic performance of axial T2-weighted MRI sequence for exclusion of brain tumour in paediatric patients with non-localizing symptoms. British Journal of Radiology, https://doi.org/10.1093/bjr/tqae244

Objective
To establish diagnostic performance of a single axial T2-weighted sequence for detection of brain tumours in children with non-localizing symptoms, compared to a standard MRI protocol.

Methods
Retrospective analysis of children undergo... Read More about Diagnostic performance of axial T2-weighted MRI sequence for exclusion of brain tumour in paediatric patients with non-localizing symptoms.

Comparison of Echo Planar and Turbo Spin Echo Diffusion‐Weighted Imaging in Intraoperative MRI (2024)
Journal Article
Thorpe, J. C., Thust, S. C., Gillon, C. H., Rowe, S., Swain, C. E., MacArthur, D. C., Howarth, S. P., Avula, S., Morgan, P. S., & Dineen, R. A. (2025). Comparison of Echo Planar and Turbo Spin Echo Diffusion‐Weighted Imaging in Intraoperative MRI. Journal of Magnetic Resonance Imaging, 61(4), 1847-1857. https://doi.org/10.1002/jmri.29614

Background
Diffusion-weighted imaging (DWI) is routinely used in brain tumor surgery guided by intraoperative MRI (IoMRI). However, conventional echo planar imaging DWI (EPI-DWI) is susceptible to distortion and artifacts that affect image quality.... Read More about Comparison of Echo Planar and Turbo Spin Echo Diffusion‐Weighted Imaging in Intraoperative MRI.

Endovascular thrombectomy vs best medical management for late presentation acute ischaemic stroke with large vessel occlusion without CT perfusion or MR imaging selection: A systematic review and meta-analysis (2024)
Journal Article
Dhillon, P. S., Marei, O., Podlasek, A., Butt, W., Rice, H., de Villiers, L., Carraro do Nascimento, V., McConachie, N., Lenthall, R., Nair, S., Malik, L., Bhogal, P., Dineen, R. A., & England, T. J. (2024). Endovascular thrombectomy vs best medical management for late presentation acute ischaemic stroke with large vessel occlusion without CT perfusion or MR imaging selection: A systematic review and meta-analysis. Journal of Stroke and Cerebrovascular Diseases, 33(11), Article 108002. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.108002

Background: The efficacy and safety of endovascular thrombectomy (EVT) beyond 6 hours from stroke onset for patients with large vessel occlusion (LVO) selected without CT perfusion(CTP) or MR imaging(MRI) is undetermined. We conducted a systematic re... Read More about Endovascular thrombectomy vs best medical management for late presentation acute ischaemic stroke with large vessel occlusion without CT perfusion or MR imaging selection: A systematic review and meta-analysis.

Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial (2024)
Journal Article
Law, Z. K., Menon, C. S., Woodhouse, L. J., Appleton, J. P., Al-Shahi Salman, R., Robinson, T., Werring, D., Roffe, C., Dineen, R. A., Bath, P. M., & Sprigg, N. (2025). Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial. European Stroke Journal, 10(1), 206-215. https://doi.org/10.1177/23969873241265939

Introduction:
The Tranexamic acid for IntraCerebral Haemorrhage-2 (TICH-2) trial reported no significant improvement in death and dependency at day 90 despite reductions in haematoma expansion, early neurological deterioration and early death. Howev... Read More about Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial.

Feasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study (2024)
Journal Article
Neves, R., Panek, R., Clarkson, K., Wilne, S., Panagioti, O., Suri, M., Whitehouse, W. P., Fernandez, N. S., Dandapani, M., Glazebrook, C., Dineen, R. A., & Jagani, S. (2024). Feasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study. Cancer Medicine, 13(14), Article e70049. https://doi.org/10.1002/cam4.70049

Background/Objectives: Ataxia telangiectasia (A‐T) is an inherited multisystem disorder with increased sensitivity to ionising radiation and elevated cancer risk. Although other cancer predisposition syndromes have established cancer screening protoc... Read More about Feasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study.

The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial (2024)
Journal Article
Hollingworth, M., Woodhouse, L. J., Law, Z. K., Ali, A., Krishnan, K., Dineen, R. A., Christensen, H., England, T. J., Roffe, C., Werring, D., Peters, N., Ciccone, A., Robinson, T., Członkowska, A., Bereczki, D., Egea-Guerrero, J. J., Ozturk, S., Bath, P. M., & Sprigg, N. (2024). The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial. Neurosurgery, 95(3), 605-616. https://doi.org/10.1227/neu.0000000000002961

BACKGROUND AND OBJECTIVES:
An important proportion of patients with spontaneous intracerebral hemorrhage (ICH) undergo neurosurgical intervention to reduce mass effect from large hematomas and control the complications of bleeding, including hemato... Read More about The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial.

CHIASM-Net: Artificial Intelligence-Based Direct Identification of Chiasmal Abnormalities in Albinism (2023)
Journal Article
Puzniak, R. J., Prabhakaran, G. T., McLean, R. J., Stober, S., Ather, S., Proudlock, F. A., Gottlob, I., Dineen, R. A., & Hoffmann, M. B. (2023). CHIASM-Net: Artificial Intelligence-Based Direct Identification of Chiasmal Abnormalities in Albinism. Investigative Ophthalmology & Visual Science, 64(13), Article 14. https://doi.org/10.1167/iovs.64.13.14

Purpose: Albinism is a congenital disorder affecting pigmentation levels, structure, and function of the visual system. The identification of anatomical changes typical for people with albinism (PWA), such as optic chiasm malformations, could become... Read More about CHIASM-Net: Artificial Intelligence-Based Direct Identification of Chiasmal Abnormalities in Albinism.

Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia (2023)
Journal Article
Woodhouse, L. J., Appleton, J. P., Christensen, H., Dineen, R. A., England, T. J., James, M., Krishnan, K., Montgomery, A. A., Ranta, A., Robinson, T. G., Sprigg, N., & Bath, P. M. (2023). Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia. Scientific Reports, 13, Article 11717. https://doi.org/10.1038/s41598-023-38474-2

Intensive antiplatelet therapy did not reduce recurrent stroke/transient ischaemic attack (TIA) events as compared with guideline treatment in the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial, but did increase th... Read More about Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia.

Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial (2023)
Journal Article
Desborough, M. J. R., Al-Shahi Salman, R., Stanworth, S. J., Havard, D., Woodhouse, L. J., Craig, J., Krishnan, K., Brennan, P. M., Dineen, R. A., Coats, T. J., Hepburn, T., Bath, P. M., Sprigg, N., & for DASH trial investigators, F. D. T. I. (2023). Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial. Lancet Neurology, 22(7), 557-567. https://doi.org/10.1016/S1474-4422%2823%2900157-6

Background: The risk of death from spontaneous intracerebral haemorrhage is increased for people taking antiplatelet drugs. We aimed to assess the feasibility of randomising patients on antiplatelet drug therapy with spontaneous intracerebral haemorr... Read More about Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial.

Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes (2023)
Journal Article
Martinez-Heras, E., Solana, E., Vivó, F., Lopez-Soley, E., Calvi, A., Alba-Arbalat, S., Schoonheim, M. M., Strijbis, E. M., Vrenken, H., Barkhof, F., Rocca, M. A., Filippi, M., Pagani, E., Groppa, S., Fleischer, V., Dineen, R. A., Ballenberg, B., Lukas, C., Pareto, D., Rovira, A., …Llufriu, S. (2023). Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes. Journal of Neurology, Neurosurgery and Psychiatry, 94(11), 916-923. https://doi.org/10.1136/jnnp-2023-331531

Background: We aimed to describe the severity of the changes in brain diffusion-based connectivity as multiple sclerosis (MS) progresses and the microstructural characteristics of these networks that are associated with distinct MS phenotypes.

Met... Read More about Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes.