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All Outputs (41)

Guidelines and practice: antipsychotics prescribing and physical health monitoring in children and young people, a cohort study using primary care data (2025)
Journal Article
Vinogradova, Y., Jack, R. H., Prasad, V., Coupland, C., Morriss, R., & Hollis, C. (2025). Guidelines and practice: antipsychotics prescribing and physical health monitoring in children and young people, a cohort study using primary care data. BMJ Mental Health, 28(1), 1-8. https://doi.org/10.1136/bmjment-2024-301287

Background: Antipsychotic treatments require physical health monitoring (PHM), especially among children and young people (CYP).
Objective: For CYP aged 5-17, to investigate recorded indications for antipsychotics prescribing and first-treatment dur... Read More about Guidelines and practice: antipsychotics prescribing and physical health monitoring in children and young people, a cohort study using primary care data.

Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial (2023)
Journal Article
Ayling, K., Brown, M., Carlisle, S., Bennett, R., Buchanan, H., Dumbleton, J., Hawkey, C., Hoschler, K., Jack, R. H., Nguyen-Van-Tam, J., Royal, S., Turner, D., Zambon, M., Fairclough, L., & Vedhara, K. (2023). Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial. Health Psychology, 43(2), 77-88. https://doi.org/10.1037/hea0001267

Objective: This trial explored the psychological and immunological effects of two brief interventions, targeting improving positive mood, administered to older adults immediately prior to influenza vaccination. The primary aim was to examine whether... Read More about Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial.

Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data (2023)
Journal Article
Jack, R. H., Joseph, R. M., Hollis, C., Hippisley-Cox, J., Butler, D., Waldram, D., & Coupland, C. (2023). Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data. BMJ Mental Health, 26(1), Article e300855. https://doi.org/10.1136/bmjment-2023-300855

Background There is an increasing demand for mental health services for young people, which may vary across the year.

Objective To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in... Read More about Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records (2023)
Journal Article
Joseph, R. M., Knaggs, R. D., Coupland, C. A., Taylor, A., Vinogradova, Y., Butler, D., Gerrard, L., Waldram, D., Iyen, B., Akyea, R. K., Ashcroft, D. M., Avery, A. J., & Jack, R. H. (2023). Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records. BMC Geriatrics, 23(1), Article 435. https://doi.org/10.1186/s12877-023-04143-2

Background Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of routine medication reviews for old... Read More about Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study (2023)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C. A., Hall, C. L., & Hollis, C. (2023). Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study. eClinicalMedicine, 57, Article 101857. https://doi.org/10.1016/j.eclinm.2023.101857

Background: Since the onset of the coronavirus (COVID-19) pandemic, clinicians have reported an increase in presentations of sudden and new onset tics particularly affecting teenage girls. This population-based study aimed to describe and compare the... Read More about Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study.

Relationship between ethnicity and stage at diagnosis in England: a national analysis of six cancer sites (2023)
Journal Article
Fry, A., White, B., Nagarwalla, D., Shelton, J., & Jack, R. H. (2023). Relationship between ethnicity and stage at diagnosis in England: a national analysis of six cancer sites. BMJ Open, 13(1), Article e062079. https://doi.org/10.1136/bmjopen-2022-062079

Objectives: Cancer stage at diagnosis is a determinant of treatment options and survival. Previous research has shown differences in barriers to presentation with cancer between ethnic groups. The completeness and quality of cancer stage and ethnicit... Read More about Relationship between ethnicity and stage at diagnosis in England: a national analysis of six cancer sites.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., Hippisley-Cox, J., & Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., Hippisley-Cox, J., & Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background
Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Preprint / Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Butler, D., Cipriani, A., Cortese, S., & Hippisley-Cox, J. (2020). Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study. PLoS Medicine, 17(7), Article e1003215. https://doi.org/10.1371/journal.pmed.1003215

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study (2020)
Journal Article
Welch, C. A., Sweeting, M. J., Lambert, P. C., Rutherford, M. J., Jack, R. H., West, D., Adlam, D., & Peake, M. (2020). Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study. British Journal of Cancer, 123, 471–479. https://doi.org/10.1038/s41416-020-0869-8

©2020, The Author(s). Background: The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical re... Read More about Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study.

Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database (2020)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C., Butler, D., Hollis, C., Morriss, R., Knaggs, R. D., Cipriani, A., Cortese, S., & Hippisley-Cox, J. (2020). Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database. BMC Medicine, 18(1), Article 93. https://doi.org/10.1186/s12916-020-01560-7

© 2020 The Author(s). Background: Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in children an... Read More about Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database.

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., Cortese, S., & Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction
Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England. (2018)
Journal Article
Tataru, D., Spencer, K., Bates, A., Wieczorek, A., Jack, R. H., Peake, M. D., Lind, M. J., & Lüchtenborg, M. (2018). Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England. Cancer Epidemiology, 57, 13-23. https://doi.org/10.1016/j.canep.2018.09.001

Objectives: We aimed to determine the geographical variation in the proportion of non-small cell lung cancer (NSCLC) patients undergoing curative treatment and assess the relationship between treatment access rates and survival outcomes.

Methods:... Read More about Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England..

Lung cancer stage-shift following a symptom awareness campaign (2018)
Journal Article
Kennedy, M., Cheyne, L., Darby, M., Plant, P., Milton, R., Robson, J., Gill, A., Malhotra, P., Ashford-Turner, V., Rodger, K., Paramasivam, E., Johnstone, A., Bhartia, B., Karthik, S., Foster, C., Lovatt, V., Hewitt, F., Cresswell, L., Coupland, V. H., Lüchtenborg, M., …Callister, M. E. (2018). Lung cancer stage-shift following a symptom awareness campaign. Thorax, 73(12), 1128-1136. https://doi.org/10.1136/thoraxjnl-2018-211842

Background: Lung cancer outcomes in the UK are worse than in many other developed nations. Symptom awareness campaigns aim to diagnose patients at an earlier stage to improve cancer outcomes.
Methods: An early diagnosis campaign for lung cancer comm... Read More about Lung cancer stage-shift following a symptom awareness campaign.

Apples and pears? A comparison of two sources of national lung cancer audit data in England (2017)
Journal Article
Khakwani, A., Jack, R. H., Vernon, S., Dickinson, R., Wood, N., Harden, S., Beckett, P., Woolhouse, I., & Hubbard, R. B. (2017). Apples and pears? A comparison of two sources of national lung cancer audit data in England. ERJ Open Research, 3(3), 00003-2017. https://doi.org/10.1183/23120541.00003-2017

In 2014, the method of data collection from NHS trusts in England for the National Lung Cancer Audit (NLCA) was changed from a bespoke dataset called LUCADA (Lung Cancer Data). Under the new contract, data are submitted via the Cancer Outcome and Ser... Read More about Apples and pears? A comparison of two sources of national lung cancer audit data in England.

Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England (2016)
Journal Article
Møller, H., Henson, K., Lüchtenborg, M., Broggio, J., Charman, J., Coupland, V. H., Davies, E., Jack, R. H., Sullivan, R., Vedsted, P., Horgan, K., Pearce, N., & Purushotham, A. (2016). Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England. British Journal of Cancer, 115(11), 1408-1415. https://doi.org/10.1038/bjc.2016.335

Background:In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items.Methods:We extracted 86 852 breast cancer records for women resident in E... Read More about Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England.

Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses (2016)
Journal Article
Davies, E. A., Coupland, V. H., Dixon, S., Mokbel, K., & Jack, R. H. (2016). Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses. BMC Cancer, 16(1), Article 421. https://doi.org/10.1186/s12885-016-2439-2

© 2016 The Author(s). Background: Data from providers of private cancer care are not yet formally included in English cancer registration data. This study aimed to test the exchange of breast cancer data from one Hospital Corporation of America Inter... Read More about Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses.

The association of mood disorders with breast cancer survival: An investigation of linked cancer registration and hospital admission data for South East England (2015)
Journal Article
Kanani, R., Davies, E. A., Hanchett, N., & Jack, R. H. (2016). The association of mood disorders with breast cancer survival: An investigation of linked cancer registration and hospital admission data for South East England. Psycho-Oncology, 25(1), 19-27. https://doi.org/10.1002/pon.4037

Background: Data linkage studies find that depression before or after a breast cancer diagnosis predicts reduced survival. This study aimed to determine whether depression or bipolar recorded in routine hospital admission data independently predicts... Read More about The association of mood disorders with breast cancer survival: An investigation of linked cancer registration and hospital admission data for South East England.