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Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint) (2019)
Other
Andrews, J., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., & Hollis, C. (in press). Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint)

Background: Remote measurement technologies (RMTs) can be used to collect data on a variety of bio-behavioural variables, which may benefit the care of people with central nervous system disorders. While various studies have explored their potential... Read More about Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint).

Qualitative investigation of relatives’ and service users’ experience of mental healthcare for suicidal behaviour in bipolar disorder (2019)
Journal Article
Clements, C., Kapur, N., Jones, S. H., Morriss, R., & Peters, S. (2019). Qualitative investigation of relatives’ and service users’ experience of mental healthcare for suicidal behaviour in bipolar disorder. BMJ Open, 9(11), 1-10. https://doi.org/10.1136/bmjopen-2019-030335

Objective: People with bipolar disorder are known to be at high risk of engaging in suicidal behaviours, and those who die by suicide have often been in recent contact with mental health services. The objective of this study was to explore suicidal b... Read More about Qualitative investigation of relatives’ and service users’ experience of mental healthcare for suicidal behaviour in bipolar disorder.

Extending the use of routine outcome monitoring: Predicting long-term outcomes in cognitive behavioral therapy for severe health anxiety (2019)
Journal Article
Malins, S., Moghaddam, N., Morriss, R., & Schröder, T. (2020). Extending the use of routine outcome monitoring: Predicting long-term outcomes in cognitive behavioral therapy for severe health anxiety. Psychotherapy Research, 30(5), 662-674. https://doi.org/10.1080/10503307.2019.1657250

Objective: Routine outcome monitoring (ROM) is a well-evidenced means of improving psychotherapy’s effectiveness. However, it is unclear how meaningful ROM is for problems that span physical and mental health, such as severe health anxiety. Physical... Read More about Extending the use of routine outcome monitoring: Predicting long-term outcomes in cognitive behavioral therapy for severe health anxiety.

Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis (2019)
Journal Article
Farooqi, A., Khunti, K., Abner, S. C., Gillies, C., Morriss, R., & Seidu, S. (2019). Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 156, Article 107816. https://doi.org/10.1016/j.diabres.2019.107816

Objective: To examine the association of comorbid occurrence of diabetes and depression with risk of cardiovascular endpoints including cardiovascular mortality, coronary heart disease and stroke. Research Design and Methods: A systematic review... Read More about Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis.

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, 179(8), 1084-1093. https://doi.org/10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia. OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.

Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder (2019)
Journal Article
Morriss, R., Xydopoulos, G., Craven, M., Price, L., & Fordham, R. (2019). Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder. Journal of Affective Disorders, 253, 426-437. https://doi.org/10.1016/j.jad.2019.04.020

© 2019 Elsevier B.V. Background: Cranial electrotherapy stimulation (CES) is a well-tolerated neuromodulation treatment with demonstrated trial efficacy in anxiety disorders. The aim of the current study was to demonstrate its clinical and cost effec... Read More about Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder.

Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multi-centre randomised controlled trial (2019)
Journal Article
Morriss, R., Patel, S., Mallins, S., Guo, B., Higton, F., James, M., …Tyrer, H. (2019). Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multi-centre randomised controlled trial. BMC Medicine, 17, 1-13. https://doi.org/10.1186/s12916-019-1253-5

Background: Repeat users of unscheduled health care with severe health anxiety are challenging to engage in psychological help and incur high service costs. We investigated whether clinical and economic outcomes were improved by offering remote cogni... Read More about Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multi-centre randomised controlled trial.

Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition (2018)
Journal Article
Hidalgo-Mazzei, D., Berk, M., Cipriani, A., Cleare, A. J., Florio, A. D., Dietch, D., …Stokes, P. R. A. (2018). Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition. British Journal of Psychiatry, 214(1), 27-35. https://doi.org/10.1192/bjp.2018.257

© The Royal College of Psychiatrists 2018. Background Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to th... Read More about Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition.

Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study (2018)
Journal Article
Kendrick, D., Baker, R., Hill, T., Beckett, K., Coupland, C., Kellezi, B., …Morriss, R. (2018). Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study. Journal of Psychosomatic Research, 112, 15-24. https://doi.org/10.1016/j.jpsychores.2018.06.008

Objective: To quantify psychological morbidity and identify baseline factors associated with depression, anxiety and post-traumatic distress symptoms up to 12 months post-injury. Methods: Multicentre cohort study of 668 adults, aged 16 to 70,... Read More about Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study.

Lamotrigine for people with borderline personality disorder: a RCT (2018)
Journal Article
Crawford, M. J., Sanatinia, R., Barrett, B., Cunningham, G., Dale, O., Ganguli, P., …Reilly, J. G. (2018). Lamotrigine for people with borderline personality disorder: a RCT. Health Technology Assessment, 22(17), 1-68. https://doi.org/10.3310/hta22170

Background: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Pr... Read More about Lamotrigine for people with borderline personality disorder: a RCT.

The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial (2018)
Journal Article
Crawford, M. J., Sanatinia, R., Barrett, B., Cunningham, G., Dale, O., Ganguli, P., …Reilly, J. G. (2018). The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial. American Journal of Psychiatry, 175(8), 756-764. https://doi.org/10.1176/appi.ajp.2018.17091006

Objectives: To examine whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. Method: Multicentre, double-blind, placebo-controlled randomized trial. Between July 2013 to Novembe... Read More about The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial.

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article
Coupland, C., Hill, T., Morriss, R., Moore, M., Arthur, A., & Hippisley-Cox, J. (2018). Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database. BMC Medicine, 16(1), Article 36. https://doi.org/10.1186/s12916-018-1022-x

© 2018 The Author(s). Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. Th... Read More about Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database.

Multiple-therapy-resistant major depressive disorder: a clinically important concept (2018)
Journal Article
McAllistair-Williams, R., Christmas, D. M. B., Cleare, A. J., Currie, A., Gledhill, J., Insole, L., …Young, A. H. (2018). Multiple-therapy-resistant major depressive disorder: a clinically important concept. British Journal of Psychiatry, 212(5), 274-278. https://doi.org/10.1192/bjp.2017.33

Many novel therapeutic options for depression exist which are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinicians is when it might be appropriate to consider such ‘n... Read More about Multiple-therapy-resistant major depressive disorder: a clinically important concept.

The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial (2017)
Journal Article
Kingslake, J., Dias, R., Dawson, G. R., Simon, J., Goodwin, G. M., Harmer, C. J., …Browning, M. (2017). The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial. Trials, 18(1), Article 558. https://doi.org/10.1186/s13063-017-2247-2

Background Antidepressant medication is commonly used to treat depression. However, many patients do not respond to the first medication prescribed and improvements in symptoms are generally only detectable by clinicians 4–6 weeks after the medica... Read More about The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial.

Users’ experiences of an online intervention for Bipolar Disorder: important lessons for design and evaluation (2017)
Journal Article
Dodd, A. L., Mallinson, S., Griffiths, M., Morriss, R., Jones, S. H., & Lobban, F. (2017). Users’ experiences of an online intervention for Bipolar Disorder: important lessons for design and evaluation. Evidence-Based Mental Health, 20(4),

Background: The evidence-base for digital interventions for physical and mental health, including severe and enduring mental health difficulties, is increasing. In a feasibility trial, web-based Enhanced Relapse Prevention (ERPonline) for bipolar dis... Read More about Users’ experiences of an online intervention for Bipolar Disorder: important lessons for design and evaluation.

National survey and analysis of barriers to the utilisation of the 2005 mental capacity act by people with bipolar disorder in England and Wales (2017)
Journal Article
Morriss, R., Mudigonda, M., Bartlett, P., Chopra, A., & Jones, S. (2017). National survey and analysis of barriers to the utilisation of the 2005 mental capacity act by people with bipolar disorder in England and Wales. Journal of Mental Health, 1-8. https://doi.org/10.1080/09638237.2017.1340613

Background: The Mental Capacity Act (2005) (MCA) provides a legal framework for advance planning for both health and welfare in England and Wales for people if they lose mental capacity e.g. through mania or severe depression. Aims: To determine the... Read More about National survey and analysis of barriers to the utilisation of the 2005 mental capacity act by people with bipolar disorder in England and Wales.

Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial (2017)
Journal Article
Tyrer, P., Tyrer, H., Morriss, R., Crawford, M., Cooper, S., Yang, M., …Barrett, B. (in press). Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial. Open Heart, 4(1), Article e000582. https://doi.org/10.1136/openhrt-2016-000582

Objective: To investigate the cost-effectiveness of a modified form of cognitive behaviour therapy for recurrent non-cardiac chest pain. Methods: We tested the effectiveness and cost-effectiveness of a modified form of cognitive behaviour therapy fo... Read More about Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial.

Assessing Feasibility and Acceptability of Web-Based Enhanced Relapse Prevention for Bipolar Disorder (ERPonline): A Randomized Controlled Trial (2017)
Journal Article
Lobban, F., Dodd, A. L., Sawczuk, A. P., Asar, O., Dagnan, D., Diggle, P. J., …Jones, S. (2017). Assessing Feasibility and Acceptability of Web-Based Enhanced Relapse Prevention for Bipolar Disorder (ERPonline): A Randomized Controlled Trial. Journal of Medical Internet Research, 19(3), Article e85. https://doi.org/10.2196/jmir.7008

Background: Interventions that teach people with bipolar disorder (BD) to recognize and respond to early warning signs (EWS) of relapse are recommended but implementation in clinical practice is poor. Objectives: The objective of this study was to te... Read More about Assessing Feasibility and Acceptability of Web-Based Enhanced Relapse Prevention for Bipolar Disorder (ERPonline): A Randomized Controlled Trial.