Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers
(2015)
Journal Article
DNA replication?associated mutations are repaired by two components: polymerase proofreading and mismatch repair. The mutation consequences of disruption to both repair components in humans are not well studied. We sequenced cancer genomes from child... Read More about Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.