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Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography (2019)
Journal Article

To allow wearable magnetoencephalography (MEG) recordings to be made on unconstrained subjects the spatially inhomogeneous remnant magnetic field inside the magnetically shielded room (MSR) must be nulled. Previously, a large bi-planar coil system wh... Read More about Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography.

Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI (2018)
Journal Article

It is commonly assumed that the human auditory cortex is organized similarly to that of macaque monkeys, where the primary region, or “core,” is elongated parallel to the tonotopic axis (main direction of tonotopic gradients), and subdivided across t... Read More about Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI.

Exploring the relative efficacy of motion artefact correction techniques for EEG data acquired during simultaneous fMRI (2018)
Journal Article

Simultaneous EEG-fMRI allows multi-parametric characterisation of brain function, in principle enabling a more complete understanding of brain responses; unfortunately the hostile MRI environment severely reduces EEG data quality. Simply eliminating... Read More about Exploring the relative efficacy of motion artefact correction techniques for EEG data acquired during simultaneous fMRI.

Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function (2018)
Journal Article
Tierney, T. M., Holmes, N., Meyer, S. S., Boto, E., Roberts, G., Leggett, J., …Barnes, G. R. (2018). Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function. NeuroImage, 181, 513-520. https://doi.org/10.1016/j.neuroimage.2018.07.035

Recent work has demonstrated that Optically Pumped Magnetometers (OPMs) can be utilised to create a wearable Magnetoencephalography (MEG) system that is motion robust. In this study, we use this system to map eloquent cortex using a clinically valida... Read More about Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function.

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography (2018)
Journal Article
Holmes, N., Leggett, J., Boto, E., Roberts, G., Hill, R. M., Tierney, T. M., …Bowtell, R. (2018). A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography. NeuroImage, 181, 760-774. https://doi.org/10.1016/j.neuroimage.2018.07.028

Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements to be made during recording. The small dynamic range of these sensors however... Read More about A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

Microstructural imaging of the human brain with a ‘super-scanner’: 10 key advantages of ultra-strong gradients for diffusion MRI (2018)
Journal Article
Jones, D., Alexander, D., Bowtell, R. W., Cercignani, M., Dell'Acqua, F., McHugh, D., …Tax, C. (2018). Microstructural imaging of the human brain with a ‘super-scanner’: 10 key advantages of ultra-strong gradients for diffusion MRI. NeuroImage, 182, 8-38. https://doi.org/10.1016/j.neuroimage.2018.05.047

The key component of a microstructural diffusion MRI ‘super-scanner’ is a dedicated high-strength gradient system that enables stronger diffusion weightings per unit time compared to conventional gradient designs. This can, in turn, drastically short... Read More about Microstructural imaging of the human brain with a ‘super-scanner’: 10 key advantages of ultra-strong gradients for diffusion MRI.

Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet (2018)
Journal Article
Cronin, M., & Bowtell, R. W. (2018). Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet. Scientific Reports, 8, Article 6259. https://doi.org/10.1038/s41598-018-24650-2

Magnetic susceptibility is an important source of contrast in magnetic resonance imaging (MRI), with spatial variations in the susceptibility of tissue affecting both the magnitude and phase of the measured signals. This contrast has generally been i... Read More about Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet.

Moving magnetoencephalography towards real-world applications with a wearable system (2018)
Journal Article
Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., …Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, 657-661. https://doi.org/10.1038/nature26147

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessibl... Read More about Moving magnetoencephalography towards real-world applications with a wearable system.

On the potential of a new generation of magnetometers for MEG: A beamformer simulation study (2016)
Journal Article
Boto, E., Bowtell, R. W., Kruger, P., Fromhold, T. M., Morris, P. G., Meyer, S. S., …Brookes, M. J. (2016). On the potential of a new generation of magnetometers for MEG: A beamformer simulation study. PLoS ONE, 11(8), Article e0157655. https://doi.org/10.1371/journal.pone.0157655

Magnetoencephalography (MEG) is a sophisticated tool which yields rich information on the spatial, spectral and temporal signatures of human brain function. Despite unique potential, MEG is limited by a low signal-to-noise ratio (SNR) which is caused... Read More about On the potential of a new generation of magnetometers for MEG: A beamformer simulation study.

Global signal modulation of single-trial fMRI response variability: effect on positive vs negative BOLD response relationship (2016)
Journal Article
Mayhew, S. D., Mullinger, K. J., Ostwald, D., Porcaro, C., Bowtell, R. W., Bagshaw, A. P., & Francis, S. T. (2016). Global signal modulation of single-trial fMRI response variability: effect on positive vs negative BOLD response relationship. NeuroImage, 133, https://doi.org/10.1016/j.neuroimage.2016.02.077

In functional magnetic resonance imaging (fMRI), the relationship between positive BOLD responses (PBRs) and negative BOLD responses (NBRs) to stimulation is potentially informative about the balance of excitatory and inhibitory brain responses in se... Read More about Global signal modulation of single-trial fMRI response variability: effect on positive vs negative BOLD response relationship.

Vertex Stimulation as a Control Site for Transcranial Magnetic Stimulation: A Concurrent TMS/fMRI Study (2015)
Journal Article

Background A common control condition for transcranial magnetic stimulation (TMS) studies is to apply stimulation at the vertex. An assumption of vertex stimulation is that it has relatively little influence over on-going brain processes involved in... Read More about Vertex Stimulation as a Control Site for Transcranial Magnetic Stimulation: A Concurrent TMS/fMRI Study.

Effects of white matter microstructure on phase and susceptibility maps (2015)
Journal Article
Wharton, S., & Bowtell, R. W. (in press). Effects of white matter microstructure on phase and susceptibility maps. Magnetic Resonance in Medicine, 173(3), https://doi.org/10.1002/mrm.25189

Purpose: To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM). Methods: The frequency offsets in a WM tissue... Read More about Effects of white matter microstructure on phase and susceptibility maps.