All Outputs (69)

Regulation of the reproductive cycle and early pregnancy by relaxin family peptides (2013)
Journal Article
Anand-Ivell, R., & Ivell, R. (2014). Regulation of the reproductive cycle and early pregnancy by relaxin family peptides. Molecular and Cellular Endocrinology, 382(1), https://doi.org/10.1016/j.mce.2013.08.010

The relaxin family of peptide hormones are structurally closely related to one another sharing a heterodimeric A–B structure, like that of insulin. They may also be active as unprocessed B–C–A pro-forms. Relaxin has been shown to pay a key role withi... Read More about Regulation of the reproductive cycle and early pregnancy by relaxin family peptides.

Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model (2013)
Journal Article
Ivell, R., Dai, Y., Mann, N., & Anand-Ivell, R. (2014). Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model. Molecular and Cellular Endocrinology, 382(1), https://doi.org/10.1016/j.mce.2013.04.016

Steroidogenic tissues such as the ovary, testes or adrenal glands are paradoxical in that they often indicate actions of steroid hormones within a dynamic range of ligand concentration in a high nanomolar or even micromolar level, i.e. at the natural... Read More about Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model.

INSL3 as a biomarker of Leydig cell functionality (2013)
Journal Article
Ivell, R., Wade, J. D., & Anand-Ivell, R. (2013). INSL3 as a biomarker of Leydig cell functionality. Biology of Reproduction, 88(6), https://doi.org/10.1095/biolreprod.113.108969

Insulin-like factor 3 (INSL3) is a small peptide hormone made and secreted uniquely by mature Leydig cells in the testes of all mammals. Importantly, this expression and secretion appears to be constitutive and therefore reflects the differentiation... Read More about INSL3 as a biomarker of Leydig cell functionality.

Ovarian expression of Insulin-Like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles (2013)
Journal Article
Satchell, L., Glister, C., Bleach, E. C., Glencross, R. G., Bicknell, A. B., Dai, Y., Anand-Ivell, R., Ivell, R., & Knight, P. G. (2013). Ovarian expression of Insulin-Like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles. Endocrinology, 154(5), https://doi.org/10.1210/en.2012-2232

Insulin-like peptide 3 (INSL3), a major product of testicular Leydig cells, is also expressed by the ovary, but its functional role remains poorly understood. Here, we quantified expression of INSL3 and its receptor RXFP2 in theca interna cell (TIC)... Read More about Ovarian expression of Insulin-Like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles.

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production (2013)
Journal Article
Glister, C., Satchell, L., Bathgate, R. A., Wade, J. D., Dai, Y., Ivell, R., Anand-Ivell, R., Rodgers, R. J., & Knight, P. G. (2013). Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proceedings of the National Academy of Sciences, 110(15), Article E1426-E1435. https://doi.org/10.1073/pnas.1222216110

Bone morphogenetic proteins (BMPs) are firmly implicated as intraovarian regulators of follicle development and steroidogenesis. Here we report a microarray analysis showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (... Read More about Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.

Neohormones as biomarkers of reproductive health (2013)
Journal Article
Anand-Ivell, R., Dai, Y., & Ivell, R. (2013). Neohormones as biomarkers of reproductive health. Fertility and Sterility, 99(4), https://doi.org/10.1016/j.fertnstert.2012.12.023

Neohormone systems are defined as evolutionarily new endocrine or paracrine adaptations that supplement basic physiologic functions and define mammalian success. The relaxin family of peptide hormones are typical neohormones. Because they define the... Read More about Neohormones as biomarkers of reproductive health.

Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring (2013)
Journal Article
Ivell, R., Heng, K., Nicholson, H., & Anand-Ivell, R. (2013). Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring. Asian Journal of Andrology, 15(2), https://doi.org/10.1038/aja.2012.138

Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestatio... Read More about Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring.

Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: Temporal trends and timing of amniocentesis in pregnancy (2012)
Journal Article
Jensen, M. S., Norgaard-Pedersen, B., Toft, G., Hougaard, D. M., Bonde, J. P., Cohen, A., Thulstrup, A. M., Ivell, R., Anand-Ivell, R., Lindh, C. H., & Jönsson, B. A. (2012). Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: Temporal trends and timing of amniocentesis in pregnancy. Environmental Health Perspectives, 120(6), 897-903. https://doi.org/10.1289/ehp.1104522

Background: Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized windows of vulnerability. Objectives: We aimed to detect various phthalate metabolites and perf... Read More about Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: Temporal trends and timing of amniocentesis in pregnancy.

The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats (2011)
Journal Article
Heng, K., Anand-Ivell, R., Teerds, K., & Ivell, R. (2012). The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats. International Journal of Andrology, 35(3), 353-363. https://doi.org/10.1111/j.1365-2605.2011.01231.x

The manner by which endocrine-disrupting xenobiotics, such as phthalates, can induce changes in the development of the male reproductive system still remains largely unknown. Herein, we have explored the application of ethane dimethane sulphonate (ED... Read More about The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats.

Biological role and clinical significance of insulin-like peptide 3 (2011)
Journal Article
Ivell, R., & Anand-Ivell, R. (2011). Biological role and clinical significance of insulin-like peptide 3. Current Opinion in Endocrinology, Diabetes and Obesity, 18(3), 210-216. https://doi.org/10.1097/MED.0b013e3283453fe6

Purpose of Review: Insulin-like peptide 3 (INSL3) is the subject of a fast expanding literature reflecting increasing clinical application, particularly as a diagnostic parameter. This review summarizes the recent INSL3 literature published within th... Read More about Biological role and clinical significance of insulin-like peptide 3.

The special systems biology of the sperm (2011)
Journal Article
Anand-Ivell, R., & Ivell, R. (2011). The special systems biology of the sperm. Biochemical Journal, 436(3), e3-e5. https://doi.org/10.1042/BJ20110766

Spermatozoa represent a highly specialized cell type, with a minimalist structure designed to fulfil a single principal function: the transport of an intact single-copy haploid genome to the site of fertilization in the oviduct, and consequent zygote... Read More about The special systems biology of the sperm.

INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue (2011)
Journal Article
Anand-Ivell, R., Hiendleder, S., Viñoles, C., Martin, G. B., Fitzsimmons, C., Eurich, A., Hafen, B., & Ivell, R. (2011). INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue. PLoS ONE, 6(5), 1-7. https://doi.org/10.1371/journal.pone.0019821

The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first pha... Read More about INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue.

Relaxin family peptides in the male reproductive system-a critical appraisal (2010)
Journal Article
Ivell, R., Kotula-Balak, M., Glynn, D., Heng, K., & Anand-Ivell, R. (2011). Relaxin family peptides in the male reproductive system-a critical appraisal. Molecular Human Reproduction, 17(2), 71-84. https://doi.org/10.1093/molehr/gaq086

The human genome project has identified, besides ovarian relaxin (RLN), six other relaxin-like molecules (RLN3, H1-RLN, INSL3-6), most of which appear to be expressed in the testis and/or male reproductive system, together with four different G-prote... Read More about Relaxin family peptides in the male reproductive system-a critical appraisal.

Dynamics of INSL3 Peptide Expression in the Rodent Testis (2009)
Journal Article
Anand-Ivell, R., Heng, K., Hafen, B., Setchell, B., & Ivell, R. (2009). Dynamics of INSL3 Peptide Expression in the Rodent Testis. Biology of Reproduction, 81(3), 480-487. https://doi.org/10.1095/biolreprod.109.077552

The Leydig cell-specific factor insulin-like peptide 3 (INSL3) is involved in testicular descent during embryo development, and has been suggested to regulate spermatogenesis and bone metabolism in the adult. Using a new, sensitive assay specific for... Read More about Dynamics of INSL3 Peptide Expression in the Rodent Testis.

Demographic, physical and lifestyle factors associated with androgen status: The Florey Adelaide Male Ageing Study (FAMAS) (2009)
Journal Article
Atlantis, E., Martin, S. A., Haren, M. T., O'Loughlin, P. D., Taylor, A. W., Anand-Ivell, R., Ivell, R., & Wittert, G. A. (2009). Demographic, physical and lifestyle factors associated with androgen status: The Florey Adelaide Male Ageing Study (FAMAS). Clinical Endocrinology, 71(2), 261-272. https://doi.org/10.1111/j.1365-2265.2008.03463.x

Objective Plasma androgen levels are inversely associated with health in men, the age-related decline of which may result from factors other than ageing per se. This study aimed to determine the effects of demographic, physical and lifestyle factors... Read More about Demographic, physical and lifestyle factors associated with androgen status: The Florey Adelaide Male Ageing Study (FAMAS).

Biology of insulin-like factor 3 in human reproduction (2009)
Journal Article
Ivell, R., & Anand-ivell, R. (2009). Biology of insulin-like factor 3 in human reproduction. Human Reproduction Update, 15(4), 463-476. https://doi.org/10.1093/humupd/dmp011

Background: Insulin-like factor 3 (INSL3) is a neohormone that has evolved to address specific mammalian traits, in particular, the first phase of testicular descent towards the scrotum during mid-gestation. Methods: A thorough literature search was... Read More about Biology of insulin-like factor 3 in human reproduction.

Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development (2009)
Journal Article
Rijntjes, E., Swarts, H. J., Anand-Ivell, R., & Teerds, K. J. (2009). Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development. AJP - Endocrinology and Metabolism, 296(2), E305-E314. https://doi.org/10.1152/ajpendo.90750.2008

Transient hypothyroidism induced by propyl-2-thiouracyl blocks postpartum Leydig cell development. In the present study, the effects of chronic hypothyroidism on the formation of this adult-type Leydig cell population were investigated, using a more... Read More about Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development.

Relaxin signalling in primary cultures of human myometrial cells (2008)
Journal Article
Heng, K., Ivell, R., Wagaarachchi, P., & Anand-Ivell, R. (2008). Relaxin signalling in primary cultures of human myometrial cells. Molecular Human Reproduction, 14(10), 603-611. https://doi.org/10.1093/molehr/gan051

In myometrium of pigs and rats, though not humans, relaxin appears to mediate an inhibition of spontaneous and oxytocin-induced contractility, presumably acting through a G-protein coupled receptor (RXFP1) to generate cAMP. In humans, circulating rel... Read More about Relaxin signalling in primary cultures of human myometrial cells.

Insulin-like factor 3 levels in amniotic fluid of human male fetuses (2008)
Journal Article
Anand-Ivell, R., Ivell, R., Driscoll, D., & Manson, J. (2008). Insulin-like factor 3 levels in amniotic fluid of human male fetuses. Human Reproduction, 23(5), 1180-1186. https://doi.org/10.1093/humrep/den038

BACKGROUND: Rodent studies suggest that the peptide hormone insulin-like factor 3 (Insl3) made by the fetal testis is responsible for the first transabdominal phase of testicular descent, and may be affected by xenobiotics to disrupt male reproductiv... Read More about Insulin-like factor 3 levels in amniotic fluid of human male fetuses.

Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures] (2008)
Presentation / Conference Contribution
Anand-Ivell, R., Crofton, K., Ivell, R., Köhrle, J., & Kortenkamp, A. Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures]

This is a panel discussion (pages 222-223) of Kevin M. Crofton's paper Thyroid disrupting chemicals: mechanisms and mixtures.

Summary of main paper:

Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly def... Read More about Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures].