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Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicenter randomised trial (2021)
Journal Article
Wang, Y., Claiborne Johnston, S., Bath, P. M., Meng, X., Jing, J., Xie, X., …Li, H. (2021). Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicenter randomised trial. Stroke and Vascular Neurology, 6(2), Article e000791. https://doi.org/10.1136/svn-2020-000791

Background: In patients with a minor ischaemic stroke or transient ischaemic attack (TIA), separate trials have shown that dual antiplatelet therapy with clopidogrel plus aspirin (clopidogrel–aspirin) or ticagrelor plus aspirin (ticagrelor–aspirin) a... Read More about Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicenter randomised trial.

Quantitative CT radiomics-based models for prediction of haematoma expansion and poor functional outcome in primary intracerebral haemorrhage (2021)
Journal Article
Pszczolkowski, S., Manzano-Patron, J. P., Law, Z. K., Krishnan, K., Ali, A., Bath, P. M., …Dineen, R. A. (2021). Quantitative CT radiomics-based models for prediction of haematoma expansion and poor functional outcome in primary intracerebral haemorrhage. European Radiology, 31, 7945-7959. https://doi.org/10.1007/s00330-021-07826-9

Objectives To test radiomics-based features extracted from noncontrast CT of patients with spontaneous intracerebral haemorrhage for prediction of haematoma expansion and poor functional outcome and compare them with radiological signs and clinica... Read More about Quantitative CT radiomics-based models for prediction of haematoma expansion and poor functional outcome in primary intracerebral haemorrhage.

The “Flying Intervention Team”: A Novel Stroke Care Concept for Rural Areas (2021)
Journal Article
Hubert, G. J., Kraus, F., Maegerlein, C., Platen, S., Friedrich, B., Kain, H.-U., …Haberl, R. L. (2021). The “Flying Intervention Team”: A Novel Stroke Care Concept for Rural Areas. Cerebrovascular Diseases, 50(4), 375–382. https://doi.org/10.1159/000514845

Background: Endovascular treatment of large vessel occlusion in acute ischemic stroke patients is difficult to establish in remote areas, and time dependency of treatment effect increases the urge to develop health care concepts for this population.... Read More about The “Flying Intervention Team”: A Novel Stroke Care Concept for Rural Areas.

Corrigendum: Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis (2020)
Journal Article
Appleton, J. P., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Bath, P. M. (2020). Corrigendum: Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis. Frontiers in Neurology, 11, Article 625572. https://doi.org/10.3389/fneur.2020.625572

Joanna M. Wardlaw was not included as an author in the published article. The corrected Author Contributions and Funding statements appear below. AUTHOR CONTRIBUTIONS JA performed the literature search, pooled analyses, statistical analysis and inter... Read More about Corrigendum: Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis.

Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial (2020)
Journal Article
Desborough, M. J., Al-Shahi Salman, R., Stanworth, S. J., Havard, D., Brennan, P. M., Dineen, R. A., …DASH trial investigators. (2020). Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial. BMJ Open, 10(11), Article e037555. https://doi.org/10.1136/bmjopen-2020-037555

Introduction Intracerebral haemorrhage (ICH) can be devastating and is a common cause of death and disability worldwide. Pre-ICH antiplatelet drug use is associated with a 27% relative increase in 1 month case fatality compared with patients not usin... Read More about Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial.

Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial (2020)
Journal Article
Beishon, L., Woodhouse, L. J., Bereczki, D., Christensen, H. K., Collins, R., Gommans, J., …Bath, P. M. (2021). Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial. Stroke and Vascular Neurology, 6(2), 180-186. https://doi.org/10.1136/svn-2020-000498

Introduction Nitrate-induced headache is common and may signify responsive cerebral vasculature. We assessed the relationship between nitrate headache and outcome in patients with acute stroke. Materials and methods Patients were those randomised to... Read More about Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial.

Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study (2020)
Journal Article
Bath, P. M., Woodhouse, L. J., Suntrup-Krueger, S., Likar, R., Koestenberger, M., Warusevitane, A., …Dziewas, R. (2020). Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study. eClinicalMedicine, 28, Article 100608. https://doi.org/10.1016/j.eclinm.2020.100608

Background: Neurogenic dysphagia is common and has no definitive treatment. We assessed whether pharyngeal electrical stimulation (PES) is associated with reduced dysphagia. Methods: The PHAryngeal electrical stimulation for treatment of neurogenic D... Read More about Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study.

Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis (2020)
Journal Article
Appleton, J. P., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Bath, P. M. (2020). Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis. Frontiers in Neurology, 11, Article 584038. https://doi.org/10.3389/fneur.2020.584038

Background: Thrombolysis, with or without thrombectomy, for acute ischaemic stroke is associated with an increased risk of intracranial bleeding. We assessed whether treatment with glyceryl trinitrate (GTN), a nitric oxide donor, may influence the as... Read More about Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis.

Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol (2020)
Journal Article
Wardlaw, J. M., Doubal, F., Brown, R., Backhouse, E., Woodhouse, L., Bath, P., …R4VaD Investigators. (2021). Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol. European Stroke Journal, 6(1), 89-101. https://doi.org/10.1177/2396987320953312

Background: Stroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding of prevalence, trajec... Read More about Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol.

Clinical management of cerebral small vessel disease: a call for a holistic approach (2020)
Journal Article
Clancy, U., Appleton, J. P., Arteaga, C., Doubal, F. N., Bath, P. M., & Wardlaw, J. M. (2021). Clinical management of cerebral small vessel disease: a call for a holistic approach. Chinese Medical Journal, 134(2), 127-142. https://doi.org/10.1097/cm9.0000000000001177

Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive impairment, ischemic or hemorrhagic stroke, problems with mobility, and neuropsychiatric symptoms. The brain damage, seen as focal white and deep grey matter l... Read More about Clinical management of cerebral small vessel disease: a call for a holistic approach.

Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial (2020)
Journal Article
Minhas, J. S., Wang, X., Lindley, R. I., Delcourt, C., Song, L., Woodward, M., …Robinson, T. G. (2021). Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial. Journal of Hypertension, 39(2), 280-285. https://doi.org/10.1097/hjh.0000000000002640

Objective: Limited data exist on the optimum level of systolic blood pressure (BP) in thrombolyzed patients with acute ischemic stroke (AIS). We aimed to determine the effects of intensive BP lowering, specifically in patients with severe AIS who par... Read More about Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial.

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel (2020)
Journal Article
Appleton, J. P., Richardson, C., Dovlatova, N., May, J., Sprigg, N., Heptinstall, S., & Bath, P. M. (2021). Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel. Stroke and Vascular Neurology, 6(1), 103-108. https://doi.org/10.1136/svn-2020-000346

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel. The... Read More about Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel.

Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine (2020)
Journal Article
Scutt, P., Woodhouse, L. J., Montgomery, A. A., & Bath, P. M. .. (2020). Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine. BMJ Open, 10(9), Article e038765. https://doi.org/10.1136/bmjopen-2020-038765

Objectives Meta-analysis based on individual patient data (IPD) from randomised trials is superior to using published summary data since it facilitates subgroup and multiple variable analyses. Guidelines and funders expect that researchers share IPD... Read More about Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine.

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future (2020)
Journal Article
Mok, V. C., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P., …Scheltens, P. (2020). Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future. Alzheimer's and Dementia, 16(11), 1571-1581. https://doi.org/10.1002/alz.12143

We have provided an overview on the profound impact of COVID‐19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health‐care settings, including hospital, out‐pat... Read More about Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future.

Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial (2020)
Journal Article
Evans, S. R., Knutsson, M., Amarenco, P., Albers, G. W., Bath, P. M., Denison, H., …Johnston, S. C. (2020). Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clinical Trials, 17(6), 617-626. https://doi.org/10.1177/1740774520941441

Background/Aims: Standard approaches to trial design and analyses can be inefficient and non-pragmatic. Failure to consider a range of outcomes impedes evidence-based interpretation and reduces power. Traditional approaches synthesizing information o... Read More about Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial.

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis (2020)
Journal Article
Lim, S. T., Thijs, V., Murphy, S. J. X., Fernandez-Cadenas, I., Montaner, J., Offiah, C., …McCabe, D. J. H. (2020). Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis. Journal of Neurology, https://doi.org/10.1007/s00415-020-09932-y

Background The prevalence of ex vivo ‘high on-treatment platelet reactivity (HTPR)’ and its relationship with recurrent vascular events/outcomes in patients with ischaemic cerebrovascular disease (CVD) is unclear. Methods A systematic review and... Read More about Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis.

The Landscape of Videofluoroscopy in the UK: A Web-Based Survey (2020)
Journal Article
Benfield, J. K., Michou, E., Everton, L. F., Mills, C., Hamdy, S., Bath, P. M., & England, T. J. (2020). The Landscape of Videofluoroscopy in the UK: A Web-Based Survey. Dysphagia, https://doi.org/10.1007/s00455-020-10130-1

Videofluoroscopy (VFS) is considered one of the gold-standard assessments of swallowing. Whilst guidelines for the application and conduct of VFS exist, their translation into clinical practice remain challenging. To build a greater understanding on... Read More about The Landscape of Videofluoroscopy in the UK: A Web-Based Survey.

Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients (2020)
Journal Article
Everton, L. F., Benfield, J. K., Hedstrom, A., Wilkinson, G., Michou, E., England, T. J., …Hamdy, S. (2020). Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients. Scientific Reports, 10, Article 7268. https://doi.org/10.1038/s41598-020-64208-9

Post stroke dysphagia (PSD) is common and associated with poor outcome. The Dysphagia Severity Rating Scale (DSRS), which grades how severe dysphagia is based on fluid and diet modification and supervision requirements for feeding, is used for clinic... Read More about Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients.

Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan (2020)
Journal Article
Mair, G., Chappell, F., Martin, C., Dye, D., Bath, P. M., Muir, K. W., …Wardlaw, J. M. (2020). Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan. AMRC Open Research, 2, Article 20. https://doi.org/10.12688/amrcopenres.12904.1

Background: Artificial intelligence-based software may automatically detect ischaemic stroke lesions and provide an Alberta Stroke Program Early CT score (ASPECTS) on CT, and identify arterial occlusion and provide a collateral score on CTA. Large-sc... Read More about Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan.