All Outputs (188)

Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents (2023)
Journal Article
Albaugh, M. D., Hudziak, J. J., Spechler, P. A., Chaarani, B., Lepage, C., Jeon, S., …Consortium, I. (2023). Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents. Psychiatry Research: Neuroimaging, 330, Article 111614. https://doi.org/10.1016/j.pscychresns.2023.111614

Few studies have examined the association between conduct problems and cerebral cortical development. Herein, we characterize the association between age-related brain change and conduct problems in a large longitudinal, community-based sample of ado... Read More about Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents.

Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study (2023)
Journal Article
Horstman, A. M., Bawden, S. J., Spicer, A., Darwish, N., Goyer, A., Egli, L., …Simpson, E. J. (2023). Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study. American Journal of Clinical Nutrition, 117(4), 709-716. https://doi.org/10.1016/j.ajcnut.2023.01.014

Background: Owing to its role in glucose homeostasis, liver glycogen concentration ([LGly]) can be a marker of altered metabolism seen in disorders that impact the health of children. However, there is a paucity of normative data for this measure in... Read More about Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study.

Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction (2022)
Journal Article
Bawden, S. J., Hoad, C., Kaye, P., Stephenson, M., Dolman, G., James, M. W., …Aithal, G. P. (2023). Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction. Magnetic Resonance Materials in Physics, Biology and Medicine, 36(4), 553-563. https://doi.org/10.1007/s10334-022-01052-0

Objective: Magnetic resonance spectroscopy (MRS) provides a powerful method of measuring fat fraction. However, previous studies have shown that MRS results give lower values compared with visual estimates from biopsies in fibrotic livers. This study... Read More about Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction.

Anxiety onset in adolescents: a machine-learning prediction (2022)
Journal Article
Chavanne, A. V., Paillère Martinot, M. L., Penttilä, J., Grimmer, Y., Conrod, P., Stringaris, A., …IMAGEN consortium. (2022). Anxiety onset in adolescents: a machine-learning prediction. Molecular Psychiatry, https://doi.org/10.1038/s41380-022-01840-z

Recent longitudinal studies in youth have reported MRI correlates of prospective anxiety symptoms during adolescence, a vulnerable period for the onset of anxiety disorders. However, their predictive value has not been established. Individual predict... Read More about Anxiety onset in adolescents: a machine-learning prediction.

Anxiety onset in adolescents: a machine-learning prediction (2022)
Journal Article
Chavanne, A. V., Martinot, M.-L. P., Penttilä, J., Grimmer, Y., Conrod, P., Stringaris, A., …Consortium, I. (2022). Anxiety onset in adolescents: a machine-learning prediction. Molecular Psychiatry, https://doi.org/10.1038/s41380-022-01840-z

Recent longitudinal studies in youth have reported MRI correlates of prospective anxiety symptoms during adolescence, a vulnerable period for the onset of anxiety disorders. However, their predictive value has not been established. Individual predict... Read More about Anxiety onset in adolescents: a machine-learning prediction.

Cortical profiles of numerous psychiatric disorders and normal development share a common pattern (2022)
Journal Article
Cao, Z., Cupertino, R. B., Ottino-Gonzalez, J., Murphy, A., Pancholi, D., Juliano, A., …ENIGMA Addiction Working Group. (2022). Cortical profiles of numerous psychiatric disorders and normal development share a common pattern. Molecular Psychiatry, https://doi.org/10.1038/s41380-022-01855-6

The neurobiological bases of the association between development and psychopathology remain poorly understood. Here, we identify a shared spatial pattern of cortical thickness (CT) in normative development and several psychiatric and neurological dis... Read More about Cortical profiles of numerous psychiatric disorders and normal development share a common pattern.

4-dimensional local radial basis function interpolation of large, uniformly spaced datasets (2022)
Journal Article
Thewlis, J., Stevens, D., Power, H., Giddings, D., Gowland, P., & Vloeberghs, M. (2023). 4-dimensional local radial basis function interpolation of large, uniformly spaced datasets. Computer Methods and Programs in Biomedicine, 228, Article 107235. https://doi.org/10.1016/j.cmpb.2022.107235

Background and Objective: Large, uniformly spaced, complex and time varying datasets derived from high resolution medical image velocimetry can provide a wealth of information regarding small-scale transient physiological flow phenomena and pulsation... Read More about 4-dimensional local radial basis function interpolation of large, uniformly spaced datasets.

Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions (2022)
Journal Article
Hutter, J., Kohli, V., Dellschaft, N., Uus, A., Story, L., Steinweg, J. K., …Rutherford, M. A. (2022). Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions. Scientific Reports, 12(1), Article 18542. https://doi.org/10.1038/s41598-022-22008-3

Pre-labour uterine contractions, occurring throughout pregnancy, are an important phenomenon involving the placenta in addition to the myometrium. They alter the uterine environment and thus potentially the blood supply to the fetus and may thus prov... Read More about Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions.

Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium (2022)
Journal Article
Maitra, R., Horne, C. M., O'Daly, O., Papanastasiou, E., Gaser, C., Banaschewski, T., …IMAGEN Consortium. (2023). Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium. Schizophrenia Bulletin, 49(2), 309-318. https://doi.org/10.1093/schbul/sbac132

Background and Hypothesis
Psychotic Like Experiences (PLEs) are widely prevalent in children and adolescents and increase the risk of developing psychosis. Cortical gyrification characterizes brain development from in utero till about the first 2 ye... Read More about Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium.

A causal association of ANKRD37 with human hippocampal volume (2022)
Journal Article
Xu, J., Xia, X., Li, Q., Dou, Y., Suo, X., Liu, N., …Consortium, I. (2022). A causal association of ANKRD37 with human hippocampal volume. Molecular Psychiatry, 27, 4432-4445. https://doi.org/10.1038/s41380-022-01800-7

Human hippocampal volume has been separately associated with single nucleotide polymorphisms (SNPs), DNA methylation and gene expression, but their causal relationships remain largely unknown. Here, we aimed at identifying the causal relationships of... Read More about A causal association of ANKRD37 with human hippocampal volume.

Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use (2022)
Journal Article
Perkins, E. R., Joyner, K. J., Foell, J., Drislane, L. E., Brislin, S. J., Frick, P. J., …Consortium, T. I. (2022). Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use. Journal of Psychopathology and Clinical Science, 131(7), 793-807. https://doi.org/10.1037/abn0000743

This study explored the generality versus specificity of two trait-liability factors for externalizing problems — disinhibition and callousness — in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperact... Read More about Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use.

Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium (2022)
Journal Article
de Erausquin, G. A., Snyder, H., Brugha, T. S., Seshadri, S., Carrillo, M., Sagar, R., …Vahidy, F. S. (2022). Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 8(1), Article e12348. https://doi.org/10.1002/trc2.12348

Introduction: Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervo... Read More about Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.

Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence (2022)
Journal Article
Nees, F., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Grigis, A., Garavan, H., …on behalf of the IMAGEN Consortium. (2022). Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence. Brain Sciences, 12(9), Article 1187. https://doi.org/10.3390/brainsci12091187

Background: Autistic traits are commonly viewed as dimensional in nature, and as continuously distributed in the general population. In this respect, the identification of predictive values of markers such as subtle autism-related alterations in brai... Read More about Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence.

Swallow Tail Sign: Revisited (2022)
Journal Article
Brammerloh, M., Kirilina, E., Alkemade, A., Bazin, P.-L., Jantzen, C., Jäger, C., …Weiskopf, N. (2022). Swallow Tail Sign: Revisited. Radiology, 305(3), 674-677. https://doi.org/10.1148/radiol.212696

The loss of the radiologic swallow tail sign on MRI scans of the substantia nigra is a promising diagnostic marker of Parkinson disease (1), although its anatom-ic underpinning is unclear. An early influential study showed th... Read More about Swallow Tail Sign: Revisited.

Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning (2022)
Journal Article
Owens, M. M., Albaugh, M. D., Allgaier, N., Yuan, D., Robert, G., Cupertino, R. B., …Hohmann, S. (2022). Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning. Translational Psychiatry, 12(1), Article 188. https://doi.org/10.1038/s41398-022-01956-4

While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempts to identify probable causal relationshi... Read More about Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning.

Autistic traits and alcohol use in adolescents within the general population (2022)
Journal Article
Pijnenburg, L. J., Kaplun, A., de Haan, L., Janecka, M., Smith, L., Reichenberg, A., …IMAGEN Consortium. (2023). Autistic traits and alcohol use in adolescents within the general population. European Child and Adolescent Psychiatry, 32(9), 1633–1642. https://doi.org/10.1007/s00787-022-01970-3

It has been suggested that autistic traits are associated with less frequent alcohol use in adolescence. Our study seeks to examine the relationship between autistic traits and alcohol use in a large adolescent population. Leveraging data from the IM... Read More about Autistic traits and alcohol use in adolescents within the general population.

Pilot Double-Blind Randomised Controlled Trial: Effects of Jejunal Nutrition on Postprandial Distress in Diabetic Gastropathy (J4G Trial) (2022)
Journal Article
Carneiro, L., White, J., Parker, H., Hoad, C., Tucker, E., Marciani, L., …Fox, M. (2022). Pilot Double-Blind Randomised Controlled Trial: Effects of Jejunal Nutrition on Postprandial Distress in Diabetic Gastropathy (J4G Trial). Nutrients, 14(7), Article 1321. https://doi.org/10.3390/nu14071321

Nausea, vomiting and abdominal pain in diabetic patients are often attributed to diabetic gastropathy (DG). Post-pyloric (“jejunal”) enteral nutrition (JN) may improve nutrition and glycaemia in difficult cases. The acute effects of JN on postprandia... Read More about Pilot Double-Blind Randomised Controlled Trial: Effects of Jejunal Nutrition on Postprandial Distress in Diabetic Gastropathy (J4G Trial).

A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood (2022)
Journal Article
Kaiser, A., Holz, N. E., Banaschewski, T., Baumeister, S., Bokde, A. L. W., Desrivières, S., …Nees, F. (2022). A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(11), 1103-1115. https://doi.org/10.1016/j.bpsc.2022.02.003

Background: On a theoretical level, impulsivity represents a multidimensional construct associated with acting without foresight, inefficient inhibitory response control, and alterations in reward processing. On an empirical level, relationships and... Read More about A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood.

Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents (2021)
Journal Article
Ottino-González, J., Albaugh, M. D., Cao, Z., Cupertino, R. B., Schwab, N., Spechler, P. A., …Garavan, H. (2022). Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents. Addiction, 117(5), 1312-1325. https://doi.org/10.1111/add.15772

BACKGROUND AND AIMS: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults wi... Read More about Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., …Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.