All Outputs (96)

Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation (2022)
Journal Article
Leighton, P. A., Dias, J., & Brearley, S. (2022). Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation. Bone & Joint Open, 3(8), 641-647. https://doi.org/10.1302/2633-1462.38.BJO-2022-0042.R1

Aims To explore individuals’ experience of a scaphoid waist fracture and its subsequent treatment. Methods A purposive sample was created, consisting of 49 participants in the Scaphoid Waist Internal Fixation for Fractures Trial of initial surgery co... Read More about Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation.

Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial (2022)
Journal Article
Topcu, G., Smith, L., Mhizha-Murira, J. R., Goulden, N., Hoare, Z., Drummond, A., …On behalf of the NEuRoMS Collective. (2022). Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies, 8(1), Article 123. https://doi.org/10.1186/s40814-022-01073-5

Background: Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability to work, and quality of life. Addressing cognitive problems is a top 10 research priority for people with MS. Our ongoin... Read More about Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial.

Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial (2022)
Journal Article
Leighton, P., Chalmers, J. R., Batchelor, J., Rogers, A., Akram, P., Haines, R. H., …Thomas, K. S. (2022). Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial. Clinical and Experimental Dermatology, 47(8), 1480-1489. https://doi.org/10.1111/ced.15193

Background: The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better treatment response than potent TCS alone. However, it... Read More about Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., …Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people (2022)
Journal Article
Ong, T., Suazo Di Paola, A., Brookes, C., Drummond, A., Hendrick, P., Leighton, P., …Sahota, O. (2022). ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people. BMJ Open, 12(5), Article e050535. https://doi.org/10.1136/bmjopen-2021-050535

Objective To determine the feasibility of designing and conducting a definitive trial to evaluate the effectiveness of sacral fracture fixation compared with non-surgical management among older people admitted with a lateral compression pelvic fragil... Read More about ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people.

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study (2022)
Journal Article
Bates, J., Stanton, H., Cannings-John, R., Thomas, K. S., Leighton, P., Howells, L. M., …Ingram, J. R. (2022). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study. BMJ Open, 12(4), Article e060815. https://doi.org/10.1136/bmjopen-2022-060815

Background Hidradenitis suppurativa (HS) is a chronic, painful, inflammatory skin disease with estimates of prevalence in the European population of 1%–2%. Despite being a relatively common condition, the evidence base for management of HS is limited... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article
Gordon, A. L., Rick, C., Juszczak, E., Montgomery, A., Howard, R., Guthrie, B., …Tate, V. (2022). The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age and Ageing, 51(3), Article afac052. https://doi.org/10.1093/ageing/afac052

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.

A multidomain decision support tool to prevent falls in older people: the FinCH cluster RCT (2022)
Journal Article
Logan, P. A., Horne, J. C., Allen, F., Armstrong, S. J., Clark, A. B., Conroy, S., …Sims, E. J. (2022). A multidomain decision support tool to prevent falls in older people: the FinCH cluster RCT. Health Technology Assessment, 26(9), 1-136. https://doi.org/10.3310/cwib0236

Background
Falls in care home residents are common, unpleasant, costly and difficult to prevent.

Objectives
The objectives were to evaluate the clinical effectiveness and cost-effectiveness of the Guide to Action for falls prevention in Care Hom... Read More about A multidomain decision support tool to prevent falls in older people: the FinCH cluster RCT.

Working in partnership with the patient community to develop outline trial designs in CF (2021)
Journal Article
Rowbotham, N. J., Smith, S., Davies, G., Leighton, P., Rayner, O., Elliott, Z., …Smyth, A. R. (2022). Working in partnership with the patient community to develop outline trial designs in CF. Journal of Cystic Fibrosis, 21(2), 300-301. https://doi.org/10.1016/j.jcf.2021.12.008

In a collaboration between health professionals and the patient community, we previously identified the Top 10 priorities for clinical research in CF [ [1] ]. Here, we have used a similar approach to explore four of these priorities further and sugge... Read More about Working in partnership with the patient community to develop outline trial designs in CF.

Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation (2021)
Journal Article
Logan, P. A., Horne, J. C., Gladman, J. R., Gordon, A. L., Robertson, K., Sach, T., …Sims, E. (2021). Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation. BMJ, 375, Article e066991. https://doi.org/10.1136/bmj-2021-066991

Objectives To determine the clinical and cost effectiveness of a multifactorial fall prevention programme compared with usual care in long term care homes. Design Multicentre, parallel, cluster randomised controlled trial. Setting Long term care home... Read More about Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation.

Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs (2021)
Journal Article
Collier, F., Howes, R., Rodrigues, J., Thomas, K. S., Leighton, P., & Ingram, J. R. (2021). Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs. BJGP Open, 5(5), 1-8. https://doi.org/10.3399/BJGPO.2021.0051

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes painful discharging nodules and skin tunnels. HS has associations with several systemic diseases, including cardiovascular disease (CVD), anxiety, and depress... Read More about Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs.

Exploring the challenges of accessing medication for patients with cystic fibrosis (2021)
Journal Article
Herbert, S., Rowbotham, N., Smith, S., Wilson, P., Elliott, Z., Leighton, P., …Smyth, A. R. (2022). Exploring the challenges of accessing medication for patients with cystic fibrosis. Thorax, 77(3), 295-297. https://doi.org/10.1136/thoraxjnl-2021-217140

Reducing treatment burden in cystic fibrosis (CF) is the top research priority for patients and clinicians. Difficulty accessing medication is one aspect of treatment burden. We investigated this with an online survey available globally for patients... Read More about Exploring the challenges of accessing medication for patients with cystic fibrosis.

What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic? (2021)
Journal Article
Kulkarni, K., Shah, R., Armaou, M., Leighton, P., Mangwani, J., & Dias, J. (2021). What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic?. Bone & Joint Open, 2(8), 583-593. https://doi.org/10.1302/2633-1462.28.bjo-2021-0056.r1

COVID-19 has compounded a growing waiting list problem, with over 4.5 million patients now waiting for planned elective care in the UK. Views of patients on waiting lists are rarely considered in prioritization. Our primary aim was to understand how... Read More about What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic?.

Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study (2021)
Journal Article
Taha, R., Leighton, P., Bainbridge, C., Montgomery, A., Davis, T., & Karantana, A. (2021). Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study. BMJ Open, 11, Article 046913. https://doi.org/10.1136/bmjopen-2020-046913

Introduction
Metacarpal shaft fractures (MSF) are common traumatic hand injuries that usually affect young people of working age. They place a significant burden on healthcare resources and society, however there is a lack of evidence to guide thei... Read More about Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study.

Learning from a successful process evaluation in care homes (2021)
Journal Article
Allen, F., Darby, J., Cook, M., Evley, R., Godfrey, M., Horne, J., …Robinson, K. (2021). Learning from a successful process evaluation in care homes. Age and Ageing, 50(5), 1850-1853. https://doi.org/10.1093/ageing/afab139

Introduction
process evaluations (PE) are increasingly used in parallel with randomised controlled trials (RCT) to inform the implementation of complex health interventions. This paper explores the learning accrued from conducting a PE within the Fa... Read More about Learning from a successful process evaluation in care homes.

Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review (2021)
Journal Article
Radford, S. J., Clarke, C. G., Shinkins, B., Leighton, P., Taylor, S. A., & Moran, G. W. (2022). Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review. Frontline Gastroenterology, 13(4), 280-286. https://doi.org/10.1136/flgastro-2021-101897

Background: Ultrasound is an alternative to Magnetic Resonance Enterography, and has the potential to significantly reduce waiting times, expedite clinical decision making and improve patient experience. Point of care ultrasound is an advantage of th... Read More about Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review.

Thematic synthesis of the experiences of people with hidradenitis suppurativa: a systematic review* (2021)
Journal Article
Howells, L., Lancasterm, N., McPheem, M., Bundy, C., Ingram, J. R., Leighton, P., …Thomas, K. S. (2021). Thematic synthesis of the experiences of people with hidradenitis suppurativa: a systematic review*. British Journal of Dermatology, 185(5), 921-934. https://doi.org/10.1111/bjd.20523

Background: Although hidradenitis suppurativa (HS) is known to affect quality of life, little summative knowledge exists on how HS impacts people living with the condition. Objectives: To synthesize experiences of people with HS within published qual... Read More about Thematic synthesis of the experiences of people with hidradenitis suppurativa: a systematic review*.

Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences (2021)
Journal Article
Elwick, H., Smith, L., Mhizha-Murira, J. R., Topcu, G., Leighton, P., Drummond, A., …Das Nair, R. (2022). Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences. Neuropsychological Rehabilitation, 32(7), 1456-1474. https://doi.org/10.1080/09602011.2021.1899942

There is a growing consensus that cognitive assessments should form part of routine clinical care in Multiple Sclerosis (MS). However, what remains unclear is which assessments are preferred by “stakeholders” (including people with MS, family members... Read More about Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences.

Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Muller, I., Stuart, B., Sach, T., Hooper, J., Wilczynska, S., Steele, M., …Santer, M. (2021). Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers. BMJ Open, 11(2), Article e045583. https://doi.org/10.1136/bmjopen-2020-045583

Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.

Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review (2021)
Journal Article
Deshmukh, S. R., Mousoulis, C., Marson, B. A., Grindlay, D., Karantana, A., the Core Outcome Set for Hand Fractures and Joint Injuries in Adults Group, …Montgomery, A. A. (2021). Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review. Journal of Hand Surgery (European Volume), 46(5), 488-495. https://doi.org/10.1177/1753193420983719

© The Author(s) 2021. This study identifies the treatment outcome domains used in recently published studies on the treatment of hand fractures and joint injuries with the aim to inform development of a core outcome set. Seven databases were searched... Read More about Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review.