All Outputs (16)

A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches (2023)
Journal Article

Despite the huge potential of magnetic resonance imaging (MRI) in mapping and exploring the brain, MRI measures can often be limited in their consistency, reproducibility and accuracy which subsequently restricts their quantifiability. Nuisance nonbi... Read More about A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches.

Measuring chemical exchange saturation transfer exchange rates in the human brain using a particle swarm optimisation algorithm (2023)
Journal Article

The z‐spectrum contains many pools with different exchange rates and T 2 values, which can make it difficult to interpret in vivo data and complicates the design of experiments aimed at providing sensitivity to one pool. This work aims to characteris... Read More about Measuring chemical exchange saturation transfer exchange rates in the human brain using a particle swarm optimisation algorithm.

Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis (2022)
Journal Article

Background: Iron rims (IRs) surrounding white matter lesions (WMLs) are suggested to predict a more severe disease course. Only small longitudinal cohorts of patients with and without iron rim lesions (IRLs) have been reported so far. Objective: To a... Read More about Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis.

Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI (2021)
Journal Article

An efficient multi-slice inversion–recovery EPI (MS-IR-EPI) sequence for fast, high spatial resolution, quantitative T1 mapping is presented, using a segmented simultaneous multi-slice acquisition, combined with slice order shifting across multiple a... Read More about Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI.

Age-related differences in myeloarchitecture measured at 7 T (2020)
Journal Article

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the grey matter (GM) of the 78 cortical automated anatomical labelling (AAL) regions of the brain, and the underlying white matter in each region, in... Read More about Age-related differences in myeloarchitecture measured at 7 T.

Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging (2019)
Journal Article

Whether the integrity of normal-appearing white matter (NAWM) is preserved in neuromyelitis optica spectrum disorders (NMOSD) is open to debate. To examine whether the tissue integrity of NAWM in NMOSD is compromised compared to that in healthy contr... Read More about Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging.

Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI (2018)
Journal Article

It is commonly assumed that the human auditory cortex is organized similarly to that of macaque monkeys, where the primary region, or “core,” is elongated parallel to the tonotopic axis (main direction of tonotopic gradients), and subdivided across t... Read More about Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI.

Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI (2018)
Journal Article

Improved markers for the progression of Parkinson's disease (PD) are required. Previous work has proven that iron dependent MRI scans can detect the largest Nigrosome (N1) within the substantia nigra (SN) pars compacta and changes in PD. Histopatholo... Read More about Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI.

The z-spectrum from human blood at 7T (2017)
Journal Article

Chemical Exchange Saturation Transfer (CEST) has been used to assess healthy and pathological tissue in both animals and humans. However, the CEST signal from blood has not been fully assessed. This paper presents the CEST and nuclear Overhauser enha... Read More about The z-spectrum from human blood at 7T.

Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More about Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions.

Relationships between cortical myeloarchitecture and electrophysiological networks (2016)
Journal Article

The human brain relies upon the dynamic formation and dissolution of a hierarchy of functional networks to support ongoing cognition. However, how functional connectivities underlying such networks are supported by cortical microstructure remains poo... Read More about Relationships between cortical myeloarchitecture and electrophysiological networks.

Quantitative analysis of the z-spectrum using a numerically simulated look-up table: application to the healthy human brain at 7T (2016)
Journal Article

Purpose: To develop a method that fits a multipool model to z-spectra acquired from non–steady state sequences, taking into account the effects of variations in T1 or B1 amplitude and the results estimating the parameters for a four-pool model to des... Read More about Quantitative analysis of the z-spectrum using a numerically simulated look-up table: application to the healthy human brain at 7T.

Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions (2016)
Journal Article

Comparison of pulsed three-dimensional CEST acquisition schemes at 7 tesla: steady state versus pseudosteady state (2016)
Journal Article

Purpose: To compare two pulsed, volumetric chemical exchange saturation transfer (CEST) acquisition schemes: steady state (SS) and pseudosteady state (PS) for the same brain coverage, spatial/spectral resolution and scan time. Methods: Both schemes... Read More about Comparison of pulsed three-dimensional CEST acquisition schemes at 7 tesla: steady state versus pseudosteady state.

Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence (2015)
Journal Article

Purpose To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical g... Read More about Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence.

Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex (2013)
Journal Article

Ultra-high-field (UHF) MRI is ideally suited for structural and functional imaging of the brain. High-resolution structural MRI can be used to map the anatomical boundaries between functional domains of the brain by identifying changes related to the... Read More about Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex.