All Outputs (58)

17-year trends in radiological disease burden of multiple sclerosis at presentation (2025)
Journal Article
Taylor, M., Alrawashdeh, O., Evangelou, N., & Garjani, A. (2025). 17-year trends in radiological disease burden of multiple sclerosis at presentation. Multiple Sclerosis and Related Disorders, 102, Article 106607. https://doi.org/10.1016/j.msard.2025.106607

At a population level, MS disease progression appears to have slowed in recent years. This study assessed whether earlier detection of people with potentially milder radiological disease is contributing to these observed trends in MS disease course.... Read More about 17-year trends in radiological disease burden of multiple sclerosis at presentation.

Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial (2025)
Journal Article
De Dios Perez, B., Kendrick, D., das Nair, R., Evangelou, N., Newsome, I., & Radford, K. (2025). Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial. PLoS ONE, 20(6), Article e0325570. https://doi.org/10.1371/journal.pone.0325570

Background

People with multiple sclerosis (MS) often leave the workforce prematurely due to MS symptoms and difficulties managing workplace relationships and performance. Vocational rehabilitation (VR) can improve job retention outcomes for people... Read More about Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial.

Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis (2025)
Journal Article
Allen, C. M., Clarke, M. A., Pai, H. V., Cauchi, M., Hawken, J., Htet, Z. M., Allen-Philbey, K., Mohamed, B., Fitzsimmons, D., Das Nair, R., Morgan, P., Partlett, C., Dineen, R. A., Schmierer, K., Tallantyre, E. C., & Evangelou, N. (2025). Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis. Neurology Open Access, 1(2), Article e000017. https://doi.org/10.1212/WN9.0000000000000017

Background and Objectives
The central vein sign (CVS) describes the presence of venules within multiple sclerosis (MS) brain lesions, visible on T2*-weighted MRI. In the upcoming revision of the MS diagnostic criteria, the simplified “rule of 6” (i.... Read More about Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis.

T₁-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI (2025)
Journal Article
Marshall, M., Aphiwatthanasumet, K., Mougin, O., Stadelmann, C., Morgan, P. S., Dineen, R. A., Gowland, P., Evangelou, N., & Clarke, M. A. (2025). T₁-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI. Journal of Neuroimaging, 35(3), Article e70044. https://doi.org/10.1111/jon.70044

Background and Purpose:
Chronic active multiple sclerosis (MS) lesions represent a particularly destructive subset of lesions on pathology. However, their imaging correlates, including paramagnetic rim lesions (PRLs) detected on susceptibility-weig... Read More about T₁-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI.

Key Outcomes for a Vocational Rehabilitation Intervention for People With Multiple Sclerosis: A Nominal Group Technique Study (2025)
Journal Article
De Dios Perez, B., Senior, C., Das Nair, R., Kendrick, D., Evangelou, N., Newsome, I., & Radford, K. (2025). Key Outcomes for a Vocational Rehabilitation Intervention for People With Multiple Sclerosis: A Nominal Group Technique Study. Health Expectations, 28(2), Article e70265. https://doi.org/10.1111/hex.70265

Background: Job retention vocational rehabilitation (VR) interventions for people with multiple sclerosis (MS) can positively impact a person's independence and directly influence health and employment outcomes. However, evaluating the effectiveness... Read More about Key Outcomes for a Vocational Rehabilitation Intervention for People With Multiple Sclerosis: A Nominal Group Technique Study.

Medication use is associated with cognitive deficits in people with multiple sclerosis (2025)
Journal Article
Atiyeh, C., Garjani, A., Gilmartin, C., Tench, C., das Nair, R., Evangelou, N., & Taylor, L. A. (2025). Medication use is associated with cognitive deficits in people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 97, Article 106386. https://doi.org/10.1016/j.msard.2025.106386

Background:

People with multiple sclerosis (pwMS) receive medications with anticholinergic and sedative effects that may contribute to cognitive decline. We studied the short-term effect of these medications and polypharmacy on cognitive deficit... Read More about Medication use is associated with cognitive deficits in people with multiple sclerosis.

Vocational rehabilitation for people with multiple sclerosis in the national health service of the United Kingdom: A realist evaluation (2025)
Journal Article
De Dios Pérez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2025). Vocational rehabilitation for people with multiple sclerosis in the national health service of the United Kingdom: A realist evaluation. PLoS ONE, 20(2), Article e0319287. https://doi.org/10.1371/journal.pone.0319287

Background There is limited evidence about how vocational rehabilitation (VR) for people with multiple sclerosis (MS) can be delivered through the United Kingdom’s (UK) National Health Service (NHS) and how it works. Aim To understand the mechanisms... Read More about Vocational rehabilitation for people with multiple sclerosis in the national health service of the United Kingdom: A realist evaluation.

Consensus‐Based Guidelines for Communicating a Misdiagnosis of Multiple Sclerosis to Reduce Psychological Distress (2024)
Journal Article
Baufeldt, A. L., Evangelou, N., Moghaddam, N., Gresswell, M., & das Nair, R. (2024). Consensus‐Based Guidelines for Communicating a Misdiagnosis of Multiple Sclerosis to Reduce Psychological Distress. Brain and Behavior, 14(10), Article e70109. https://doi.org/10.1002/brb3.70109

Background
Multiple sclerosis (MS) misdiagnosis is common, and when discovered, frequently leads to substantial disruption to patients’ lives and anxiety for clinicians. Our objective was to develop expert consensus-based guidelines about how to com... Read More about Consensus‐Based Guidelines for Communicating a Misdiagnosis of Multiple Sclerosis to Reduce Psychological Distress.

Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study (2024)
Journal Article
De Dios Perez, B., Holmes, J., Elder, T., Lindley, R., Evangelou, N., das Nair, R., Senior, C., Booth, V., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2025). Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study. Disability and Rehabilitation, 47(12), 3124-3136. https://doi.org/10.1080/09638288.2024.2417031

Purpose: To implement a job retention vocational rehabilitation (VR) intervention (MSVR) for people with multiple sclerosis (MS) and their employers in the UK National Health Service (NHS). Methods: Multicentre, single-arm feasibility study with post... Read More about Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study.

Providing emotional support during the process of multiple sclerosis diagnosis (PrEliMS): A feasibility randomised controlled trial (2024)
Journal Article
Das Nair, R., Mhizha-Murira, J. R., Topcu, G., Tindall, T., Bale, C., Moghaddam, N., Scheffler-Ansari, G., Drummond, A., Fitzsimmons, D., & Evangelou, N. (2024). Providing emotional support during the process of multiple sclerosis diagnosis (PrEliMS): A feasibility randomised controlled trial. Clinical Rehabilitation, 38(11), 1506-1520. https://doi.org/10.1177/02692155241284781

Objectives
To evaluate the feasibility and acceptability of an emotional support programme for newly diagnosed people with multiple sclerosis.

Design
Three-arm, mixed methods, randomised controlled trial comparing usual care, versus usual care p... Read More about Providing emotional support during the process of multiple sclerosis diagnosis (PrEliMS): A feasibility randomised controlled trial.

Prognostic significance of paramagnetic rim lesions in multiple sclerosis: A systematic review. (2024)
Journal Article
Toru Asahina, A., Lu, J., Chugh, P., Sharma, S., Sharma, P., Tan, S., Kovoor, J., Stretton, B., Gupta, A., Sorby-Adams, A., Goh, R., Harroud, A., Clarke, M. A., Evangelou, N., Patel, S., Dwyer, A., Agzarian, M., Bacchi, S., & Slee, M. (2024). Prognostic significance of paramagnetic rim lesions in multiple sclerosis: A systematic review. Journal of Clinical Neuroscience, 129, 110810. https://doi.org/10.1016/j.jocn.2024.110810

The diagnostic potential of paramagnetic rim lesions (PRLs) has been previously established; however, the prognostic significance of these lesions has not previously been consistently described. This study aimed to establish the prognostic role of PR... Read More about Prognostic significance of paramagnetic rim lesions in multiple sclerosis: A systematic review..

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Journal Article
De Dios Perez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2024). A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom. BMC Health Services Research, 24, Article 995. https://doi.org/10.1186/s12913-024-11424-y

Background
To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS).

Methods
Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales (2024)
Journal Article
Nicholas, R., Tallantyre, E. C., Witts, J., Marrie, R. A., Craig, E. M., Knowles, S., Pearson, O. R., Harding, K., Kreft, K., Hawken, J., Ingram, G., Morgan, B., Middleton, R. M., Robertson, N., Evangelou, N., Allen, K., Schmierer, K., Galea, I., Craner, M., Chataway, J., …Sharrack, B. (2024). Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales. Journal of Neurology, Neurosurgery and Psychiatry, 95(11), 1032-1035. https://doi.org/10.1136/jnnp-2024-333532

Background

Identification of multiple sclerosis (MS) cases in routine healthcare data repositories remains challenging. MS can have a protracted diagnostic process and is rarely identified as a primary reason for admission to the hospital. Diffic... Read More about Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales.

Real‐world persistence of multiple sclerosis disease‐modifying therapies (2024)
Journal Article
Tallantyre, E. C., Dobson, R., Froud, J. L. J., St John, F. A., Anderson, V. M., Arun, T., Buckley, L., Evangelou, N., Ford, H. L., Galea, I., George, S., Gray, O. M., Hibbert, A. M., Hu, M., Hughes, S. E., Ingram, G., Kalra, S., Lim, C. E., Mathews, J. T. M., McDonnell, G. V., …Robertson, N. P. (2024). Real‐world persistence of multiple sclerosis disease‐modifying therapies. European Journal of Neurology, 31(7), Article e16289. https://doi.org/10.1111/ene.16289

Background and purpose: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real‐world rates of persistence on disease‐modifying therapies (DMTs) for p... Read More about Real‐world persistence of multiple sclerosis disease‐modifying therapies.

The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study (2024)
Journal Article
De Dios Perez, B., Pritchard, C., Powers, K., das Nair, R., Evangelou, N., Ford, H., Tallantyre, E., Dobson, R., & Radford, K. (2024). The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study. International Journal of Ms Care, 26(Q3), 174-186. https://doi.org/10.7224/1537-2073.2023-049

Background: The COVID-19 pandemic led to approximately half of the working population in the United Kingdom being unable to work temporarily. This study aims to understand the employment needs and experiences of people with multiple sclerosis (MS) in... Read More about The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study.

Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination (2023)
Journal Article
Zaloum, S. A., Wood, C. H., Tank, P., Upcott, M., Vickaryous, N., Anderson, V., Baker, D., Chance, R., Evangelou, N., George, K., Giovannoni, G., Harding, K. E., Hibbert, A., Ingram, G., Jolles, S., Kang, A. S., Loveless, S., Moat, S. J., Richards, A., Robertson, N. P., …Tallantyre, E. C. (2023). Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination. Multiple Sclerosis Journal, 29(8), 979-989. https://doi.org/10.1177/13524585231185247

Background:

People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear.

Objective:

To report CO... Read More about Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination.

Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study (2023)
Journal Article
Papathanasiou, A., Hibbert, A., Tallantyre, E., Harding, K., Selvam, A. P., Morgan, M., Quainton, C., Talaei, M., Arun, T., Ingram, G., Law, G. R., & Evangelou, N. (2023). Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study. Neurological Sciences, 44(10), 3629-3635. https://doi.org/10.1007/s10072-023-06838-1

Background: Annualized relapse rate (ARR) is used as an outcome measure in multiple sclerosis (MS) clinical trials. Previous studies demonstrated that ARR has reduced in placebo groups between 1990 and 2012. This study aimed to estimate real-world AR... Read More about Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study.

ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. (2023)
Journal Article
Jacobs, B. M., Schalk, L., Dunne, A., Scalfari, A., Nandoskar, A., Gran, B., Mein, C. A., Sellers, C., Spilker, C., Rog, D., Visentin, E., Bezzina, E. L., Uzochukwu, E., Tallantyre, E., Wozniak, E., Sacre, E., Hassan-Smith, G., Ford, H. L., Harris, J., Bradley, J., …Dobson, R. (2023). ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. BMJ Open, 13(5), Article e071656. https://doi.org/10.1136/bmjopen-2023-071656

Purpose Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The gene... Read More about ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK..

An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis (2023)
Journal Article
Dumitrescu, L., Papathanasiou, A., Coclitu, C., Garjani, A., Evangelou, N., Constantinescu, C. S., Popescu, B. O., & Tanasescu, R. (2023). An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis. Expert Opinion on Pharmacotherapy, 24(4), 495-509. https://doi.org/10.1080/14656566.2023.2178898

Multiple sclerosis (MS) is an immune-mediated disorder of the CNS manifested by recurrent attacks of neurological symptoms (related to focal inflammation) and gradual disability accrual (related to progressive neurodegeneration and neuroinflammation)... Read More about An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis.

Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study (2023)
Journal Article
Tindall, T., Topcu, G., Thomas, S., Bale, C., Evangelou, N., Drummond, A., & das Nair, R. (2023). Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study. Health Expectations, 26(2), 858-868. https://doi.org/10.1111/hex.13711

Background: Diagnosing multiple sclerosis (MS) can be a lengthy process, which can impact psychological wellbeing, condition management, and future engagement with health services. Therefore, providing timely and appropriate emotional support may imp... Read More about Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study.