Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Bath, Philip M.W.; Christensen, L M; Woodhouse, Lisa J.; Bentsen, L; Appleton, Jason P.; Krarup Hansen, C; Beridze, M.; Thomsen, T T; Christensen, Hanne; Kruuse, C; Dineen, Robert A.; Jensen, H H; Duley, Lelia; Hansen, S S; England, Timothy J.; Petrovic, V; Flaherty, Katie; Beridze, N; Havard, Diane; Kakabadze, N; Heptinstall, Stan; Kherkheulidze, T; James, Marilyn; Kakabadze, D; Krishnan, Kailash; Toidze, I; Markus, H.S.; Lobjanidze, N; Montgomery, Alan A.; Akiashvili, N; Pocock, Stuart J.; ATevdoradze; Randall, Marc; Khizanishvili, N; Ranta, A.; Tsanava, T; Robinson, Thompson G.; Taylor, R; Scutt, Polly; Iniesta, I; Venables, Graham S.; Kok, J; Sprigg, Nikola; Duignan, J; Funnell, M; Cariga, P; Rodriguez, M; Watson, I J; Tennant, S; Macleod, M; Furnace, J; Gow, H; Irvine, J; Joyson, A; Nelson, S; Taylor, V; Smith, M; Bellfield, R; Hairsine, B; Davies, R; Dodd, A; Corrigan, J; Doherty, M; Ahmed, A; Denniss, C; Johnson-Holland, S; Kay, K A; Icart Palau, R; Auld, G; Daboo, P; Erande, R; Grimwood, G; Hove, D; Howaniec, L; Redjep, O; Rangasamay, R; Butt, G; Sandler, D; Reddan, J; Stafford, S; McIlmoyle, J; Maguire, S; Murphy, P; Chambers, J; Guthrie, L; Osborn, M; Steele, A; Burn, M; Benford, A; Misra, A; Hilton, D; O'Brien, E; Amis, E; Finlay, S; Mitchell, J; Geraghty, O; Harvey, K; Hazel, B; Mashate, S; Wilding, P; Sajid, M; Ball, M; Gascoyne, R; Sivakumar, R; Wright, A; Chatterjee, K; Booth, S; Eccleson, H; Kelly, C; Leason, S; Perkins, C; Bruce, D; Brown, E; Clayton, S; Garside, M; Rogers, G; Lawrence, E; Mahmood, S; Watchurst, C; Chadha, D; Glover, L; Holford, L; Smith, K; Walstow, D; Williams, R; O'Shea, L; Goodsell, J; Athulathmudali, C; Barbon, E; Namushi, R; Jacob, P; Johnson, L; Morse, D; McGhee, C; Speirs, O; Atkinson, S; Peacocke, A; Langhorne, P; Graham, R; Wright, F; McAlpine, C; Ravindrane, A; Bajoriene, M; Matter, L; Windebank, S; Giallombardo, E; Dellafera, D; Eglinton, C; Wilson, J; Broughton, D; Chapman, K; Dixon, L; Zaidi, M; Ayes, K; Kessell, J; Manawadu, D; Adegbaju, O; Aeron-Thomas, J; Anderson, K; Brigden, A; Cattermole, E; Good, J; Hassan, S; Khoromana, E; Lee-Carbon, L; Marks, K; Mckenzie, E; Sikondari, N; Cooper, M; Whysall, K; Wynter, I; Bamford, J; Hassan, A; Wanklyn, P; Kambafwile, M; Makawa, L; Waugh, D; Veraque, E; Soliman, M G G; Arif, S; Brown, R; Butler, S; Hewitt, C; Hindle, J; Pusalkar, A; Beadle, H; Chan, K; Siddiqui, M; Dangri, P; Buddha, S; Asokanathan, A; Mistri, A; Eveson, D; Musarrat, K; Manning, L; Anand, S; Christian, P; Khan, S; Patel, C; Sein, M; Banns, J; Gibson, E; Gordon, T; Gruenbeck, Y; Wong, S; Datta, P; Bateman, G; Jackson, L; Needle, A; Duodu, Y; Oliver, R; Padilla-Harris, C; Barber, M; Esson, D; Brodie, F; McInnes, C; Fotherby, K; Butler, D; Morgan, D; Preece, K; Willberry, A; Dent, M; Hammonds, F; Hunt, J; Vernon, C; O'Kane, D; Faola, F; Lai, P; O'Callaghan, J; Smith, C; Price, C; Lakey, R; Riddell, V; Smith, A; Storey, G; Munshi, S; Buck, A; Clarke, J; Gilzeane, N; Godfrey, M; Keshvara, R; Richardson, C; Roffe, J; Ryan, L; Shelton, F; Sunman, W; Tittle, A; Tomlinson, J; Whittamore, K; Wilkes, G; Owusu-Agyei, P; Temple, N; Mangion, D; Hardwick, A; Netherton, K; MohdNor, A; Hyams, B; Norman, S; Persad, N; Ragab, S; Dickson, C; Dube, J; Jinks, E; Knops, K; Wadams, B; Ali, K; Gaylard, J; Spurling, G; Sztriha, L; Ajao, T; Alao, M; KChan, F; Webster, P; HowardT JDobson, P; Hyatt, L; Sims, D; Cunningham, J; Esisi, B; Cassidy, T; Bokhari, M; McClelland, B; Mokoena, B; Gunathilagan, G; Jones, S; Reader, M; Thomas, G; Tilby, S; Findlay, P; Barrett, F; Leslie, F; Ross, S; Shread, I; Okwera, J; Howe, J; Harrington, F; Courtauld, G; Schofield, C; Donnelly, R; Maddula, M; Scott, J; Beavan, J; Muhidden, K; Memon, I; Clarke, M; Hedstrom, A; Mills, L; Hemsley, A; Bowring, A; Boxall, L; Kingwell, H; Keenan, S; Roughan, C; Manoj, A; Cox, P; Fletcher, G; Lopez, P; Emsley, H; Gregary, B; McLoughlin, A; Raj, S; Roffe, C; Abano, N; Barry, A; Butler, A; Carpio, R; Castro, K; Finney, K; Gomm, S; Hiden, J; Grocott, J; Lyjko, S; Maguire, H; Remegoso, A; Sanyal, R; Stevens, S; Natarajan, I; Chembala, J; Muddegowda, G; Warusevitane, A; Blight, A; Balazikova, O; Lawlor, C; Shaw, L; Button, D; Howcroft, D; Lucas, S; Madigan, B; McCann, S; Dixit, A; Barkat, A; Davis, J; Fawcett, M; Finlay, L; Guy, H; Hays, C; Hogg, V; Horsley, E; Hubbuck, C; Pringle, C; Stevenson, C; Storey, K; Thompson, T; Woodward, S; Banerjee, A; Allcock, C; Merotra, S; Douglass, C; Campbell, E; Jarapa, R; Johnes, M; Keaveney, C; Marsden, T; Naing, Z; Perez, J; Shaw, K; Black, T; Anthony, A; Clarke, C; Paterson, J; Deighton, K; Temlett, E; Blank, C; Doyle, C; Duty, S; Gill, K; Harkness, K; Kamara, C; Richards, E; Elfandi, K; Guyler, P; Harman, P; Khuoge, C; Kunhunny, S; Tysoe, S; Moynihan, B; Adedoyin, T; Chopra, N; Dayal, N; Ghatala, R; Jeyaraj, N; Jones, I; Kennedy, F; Kerin, L; Khanom, N; Lewis, S; Maheswaran, S; Montague, L; Niemierko, M; O'Reilly, J; Trippier, S; Watson, F; Wilkinson, P; Young, E; Dizayee, K; Cochrane, H; O'Connell, J; Mokoena, L; Osborne, E; Nair, A; Greig, J; Jenkins, C; Powell, J; Price, F; Chowdhury, M; Brixey, S; Hunt, L; Rands, N; Rose, G; Stoddart, S; Srinivasan, M; Motherwell, N; Shekhar, R; Fuller, T; Lankester, A; Lingwood, P; Rankin, C; Webb, H; Jupp, B; Bell, J; Hann, G; Longland, B; Ovington, C; Bhaskaran, B; Ayres, G; Bailey, C; Bearne, H; Buxton, J; Fitzell, P; Hilaire, C; Kelly, D; Szabo, S; Tomlin, D; Gamble, E; Charles, B; Kumar, R; Fluskey, T; Mellor, Z; Peters, J; Sutton, V; Kenton, A; Martin, I; Nyabadza, S; Ghosh, S; Henry, M; Kumar, B; Bruce, D; Ambulo, C; Crawford, S; Nozedar, T; Platton, M; Cvoro, V; Couser, M; McCormick, K; Wilkinson, D; Javaid, K; Hurdowar, S; Attygalle, T; Sundayi, S; Orugun, O; Crowther, H; Jolly, R; Poultney, U; Azim, A; Krasinska-Chavez, M; White, J; Sengupta, N; Margalef, J; Metiu, M G; Meenakshisundaram, S; Dealing, S; Hargroves, D; Beranova, E; Cowie, L; Rudenko, H; Thomson, A; Verrion, A; Rashed, K; Board, S; Buckley, C; Hayward, D; Jenkins, K; Keeling, E; Rowland-Axe, R; Vickers, C; Wood, D; Lehman, A; Erande, R; Patel, M; Russell, H; Rehman, H; Forrest, D; Farren, P

doi:10.1016/S0140-6736(17)32849-0

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage (2020)
Journal Article
Law, Z. K., Desborough, M., Rakkar, K., Bath, P. M., Bayraktutan, U., & Sprigg, N. (2020). Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage. Brain Hemorrhages, 1(1), 75-79. https://doi.org/10.1016/j.hest.2019.12.001

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center st... Read More about Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage.

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT (2019)
Journal Article
Sprigg, N., Flaherty, K., Appleton, J. P., Al-Shahi Salman, R., Bereczki, D., Beridze, M., …Bath, P. M. (2019). Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. Health Technology Assessment, 23(35), 1-48. https://doi.org/10.3310/hta23350

BACKGROUND: Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. OBJECTIVE: The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous... Read More about Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.

The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved] (2019)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P., Kang Law, Z., …Roberts, I. (2019). The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.3

Introduction: The Anti-fibrinolytics Trialists Collaboration aims to increase knowledge about the effectiveness and safety of anti-fibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article pre... Read More about The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved].

Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial (2019)
Journal Article
van der Worp, H. B., Macleod, M. R., Bath, P. M., Bathula, R., Christensen, H., Colam, B., …the EuroHYP-1 investigators. (2019). Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial. European Stroke Journal, 4(3), 254-262. https://doi.org/10.1177/2396987319844690

© European Stroke Organisation 2019. Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In... Read More about Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.

Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review (2019)
Journal Article
Krishnan, K., Bassilious, K., Eriksen, E., Bath, P. M., Sprigg, N., Brækken, S. K., …Sandset, E. C. (2019). Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review. European Stroke Journal, 4(3), 233-239. https://doi.org/10.1177/2396987319843701

Purpose
Acute vestibular syndrome – vertigo, nausea/vomiting, nystagmus and gait unsteadiness – is common, and differentiating posterior circulation stroke from a peripheral cause can be challenging. The National Institute of Health Stroke Scale (NI... Read More about Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review.

Women in the European Stroke Organisation: one, two, many… – A Top Down and Bottom Up approach (2019)
Journal Article
Sandset, E. C., de Sousa, D. A., Christensen, H., Cordonnier, C., Fischer, U., Katan, M., …Caso, V. (2019). Women in the European Stroke Organisation: one, two, many… – A Top Down and Bottom Up approach. European Stroke Journal, 4(3), 247-253. https://doi.org/10.1177/2396987319841979

Background: An increasing proportion of physicians are women, yet they still face challenges with career advancement. In 2014, the European Stroke Organisation established the goal of increasing the number and participation of women within the societ... Read More about Women in the European Stroke Organisation: one, two, many… – A Top Down and Bottom Up approach.

Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry (2019)
Journal Article
S Anderson, C., Robinson, T. G., Bray, B. D., Paley, L., Sprigg, N., Wang, X., …for the ENCHANTED Investigators and the SSNAP Collaboration. (2019). Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry. International Journal of Stroke, 14(7), 678-685. https://doi.org/10.1177/1747493019841246

© 2019 World Stroke Organization. Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results. Methods: Comparisons were made of baseline and out... Read More about Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry.

Impact of ultra/hyper-acute administration of glyceryl trinitrate on secondary outcome after acute stroke: a meta-analysis of individual patient data from randomised trials (2018)
Presentation / Conference Contribution
Bath, P. M., Woodhouse, L. J., & Sprigg, N. (2018). Impact of ultra/hyper-acute administration of glyceryl trinitrate on secondary outcome after acute stroke: a meta-analysis of individual patient data from randomised trials.

Background Glyceryl trinitrate (GTN) is a candidate reperfusion and hypotensive treatment for hyperacute stroke. We assessed the effect of early administration of GTN (within 6 hours) on secondary outcomes (taken at 3 months post randomisation), acro... Read More about Impact of ultra/hyper-acute administration of glyceryl trinitrate on secondary outcome after acute stroke: a meta-analysis of individual patient data from randomised trials.

Recruitment challenges in MRI studies of acute intracerebral haemorrhage: experience from the TICH-2 MRI substudy (2018)
Presentation / Conference Contribution
Pszczolkowski, S., Bath, P. M., Sprigg, N., & Dineen, R. A. (2018). Recruitment challenges in MRI studies of acute intracerebral haemorrhage: experience from the TICH-2 MRI substudy.

BACKGROUND AND AIMS
Magnetic Resonance Imaging (MRI) is widely used in clinical practice and in trials for ischaemic stroke; however, relatively few large multicentre trials for intracerebral haemorrhage have used MRI. We describe the main recruitme... Read More about Recruitment challenges in MRI studies of acute intracerebral haemorrhage: experience from the TICH-2 MRI substudy.

Results from the tranexamic acid for primary intracerebral haemorrhage-2 (TICH-2) trial (2018)
Presentation / Conference Contribution
Sprigg, N., Flaherty, K., Law, Z. K., Appleton, J. P., Scutt, P., Krishnan, K., & Bath, P. M. (2018). Results from the tranexamic acid for primary intracerebral haemorrhage-2 (TICH-2) trial.

Background: Haematoma expansion leads to worse outcome in intracerebral haemorrhage (ICH). Tranexamic acid (TXA) is a promising haemostatic agent to prevent haematoma expansion and improve outcome after ICH.
Methods: TICH-2 is a multicentre prospect... Read More about Results from the tranexamic acid for primary intracerebral haemorrhage-2 (TICH-2) trial.

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial (2018)
Journal Article
Sprigg, N., Flaherty, K., Appleton, J. P., Al-Shahi Salman, R., Bereczki, D., Beridze, M., …Bath, P. M. (2018). Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet, 391(10135), 2107-2115. https://doi.org/10.1016/S0140-6736%2818%2931033-X

Background
Tranexamic acid (TXA) reduces death due to bleeding after trauma and post-partum haemorrhage. The aim was to assess if tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral 6 haemorrha... Read More about Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST) (2018)
Presentation / Conference Contribution
Appleton, J. P., Hedstrom, A., O'Sullivan, S., May, J., Sprigg, N., Bath, P. M., & England, T. J. (2018, May). Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST). Presented at 4th European Stroke Organisation Conference (ESOC 2018)

Background:
Remote ischaemic per-conditioning (RIC) in experimental ischaemic stroke is neuroprotective. Several neurohumoral, vascular and inflammatory mediators are implicated.
Methods:
The REmote ischaemic Conditioning After Stroke Trial (RECAS... Read More about Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST).

The effect of transdermal glyceryl trinitrate in acute stroke patients with carotid stenosis: data from the Efficacy of Nitric Oxide in Stroke trial (2018)
Presentation / Conference Contribution
Appleton, J., Woodhouse, L., Law, Z., Sprigg, N., & Bath, P. The effect of transdermal glyceryl trinitrate in acute stroke patients with carotid stenosis: data from the Efficacy of Nitric Oxide in Stroke trial. Presented at 4th European Stroke Organisation Conference (ESOC 2018)

Background: There is concern that blood pressure lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the context of carotid stenosis. The effect of glyceryl trinitrate (GTN) on outcome in acute stroke patients with caroti... Read More about The effect of transdermal glyceryl trinitrate in acute stroke patients with carotid stenosis: data from the Efficacy of Nitric Oxide in Stroke trial.

Characteristics and outcomes of patients with or without a bleeding event: results from the triple antiplatelets for reducing dependency in ischaemic stroke (TARDIS) trial (2018)
Presentation / Conference Contribution
Woodhouse, L. J., Flaherty, K., Appleton, J. P., Sprigg, N., & Bath, P. M. Characteristics and outcomes of patients with or without a bleeding event: results from the triple antiplatelets for reducing dependency in ischaemic stroke (TARDIS) trial. Presented at 4th European Stroke Organisation Conference (ESOC 2018)

Background: Several studies showed that hyperglycaemia is associated with poorer prognosis in intracerebral haemorrhage. We explored the characteristics and outcomes of patients with hyperglycaemia in the Tranexamic acid in IntraCerebral Haemorrhage-... Read More about Characteristics and outcomes of patients with or without a bleeding event: results from the triple antiplatelets for reducing dependency in ischaemic stroke (TARDIS) trial.

Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomised controlled trials of vasoactive drugs in acute stroke: the Blood pressure in Acute Stroke Collaboration, stage-3 (BASC-3) (2018)
Journal Article
Sandset, E. C., Sanossian, N., Woodhouse, L. J., Anderson, C., Berge, E., Lees, K. R., Potter, J. F., Robinson, T. G., Sprigg, N., Wardlow, J. M., & Bath, P. M. (2018). Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomised controlled trials of vasoactive drugs in acute stroke: the Blood pressure in Acute Stroke Collaboration, stage-3 (BASC-3). International Journal of Stroke, 13(7), 759-765. https://doi.org/10.1177/1747493018772733

Rationale
Despite several large clinical trials assessing blood pressure lowering in acute stroke, equipoise remains, particularly for ischaemic stroke. The ‘Blood pressure in Acute Stroke Collaboration’ (BASC) commenced in the mid 1990s focusing on... Read More about Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomised controlled trials of vasoactive drugs in acute stroke: the Blood pressure in Acute Stroke Collaboration, stage-3 (BASC-3).

Haemostatic therapies for acute spontaneous intracerebral haemorrhage (2018)
Journal Article
Al-Shahi Salman, R., Law, Z. K., Bath, P. M., Steiner, T., & Sprigg, N. (2018). Haemostatic therapies for acute spontaneous intracerebral haemorrhage. Cochrane Database of Systematic Reviews, Article CD005951. https://doi.org/10.1002/14651858.CD005951.pub4

Background: Outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH) is influenced by haematoma volume; up to one-third of ICHs enlarge within 24 hours of onset. Early haemostatic therapy might improve outcome by limiting haematoma g... Read More about Haemostatic therapies for acute spontaneous intracerebral haemorrhage.

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial (2018)
Journal Article
Al-Shahi Salman, R., Dennis, M. S., Murray, G. D., Innes, K., Drever, J., Dinsmore, L., …Werring, D. J. (2018). The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19(1), Article 162. https://doi.org/10.1186/s13063-018-2542-6

Background

For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is... Read More about The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved] (2018)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P. M., Kang Law, Z., …Roberts, I. (2018). The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.2

© 2018 Ker K et al. Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.... Read More about The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved].

A European, multicentre, phase III, clinical trial of hypothermia for acute ischaemic stroke: EuroHYP-1 (2018)
Presentation / Conference Contribution
Sprigg, N., Bath, P. M., Smithson, J., Lees, K. R., Macleod, M. R., van der Worp, H. B., …Schwab, S. (2018). A European, multicentre, phase III, clinical trial of hypothermia for acute ischaemic stroke: EuroHYP-1.

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial (2017)
Journal Article
Bath, P. M., Christensen, L. M., Woodhouse, L. J., Bentsen, L., Appleton, J. P., Krarup Hansen, C., Beridze, M., Thomsen, T. T., Christensen, H., Kruuse, C., Dineen, R. A., Jensen, H. H., Duley, L., Hansen, S. S., England, T. J., Petrovic, V., Flaherty, K., Beridze, N., Havard, D., Kakabadze, N., …Farren, P. (2018). Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391(10123), 850-859. https://doi.org/10.1016/S0140-6736%2817%2932849-0

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

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