Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

Law, Zhe Kang; Desborough, Michael; Rakkar, Kamini; Bath, Philip M.; Bayraktutan, Ulvi; Sprigg, Nikola

Abstract

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study. Patients with ICH had significantly higher D-dimer and plasmin-alpha-2-antiplasmin complexes compared to HC. At baseline, patients with hematoma progression had higher urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) and lower plasminogen levels, compared to those with no progression. 24-hour and day-7 matrix metalloproteinase-9 (MMP-9) was significantly increased in patients with hematoma progression.

Citation

Law, Z. K., Desborough, M., Rakkar, K., Bath, P. M., Bayraktutan, U., & Sprigg, N. (2020). Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage. Brain Hemorrhages, 1(1), 75-79. https://doi.org/10.1016/j.hest.2019.12.001

• Journal Article Type: Article
• Acceptance Date: Dec 19, 2019
• Online Publication Date: Jan 23, 2020
• Publication Date: Mar 1, 2020
• Deposit Date: Jan 29, 2020
• Publicly Available Date: Jan 29, 2020
• Journal: Brain Hemorrhages
• Print ISSN: 2589-238X
• Electronic ISSN: 2589-238X
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 1
• Pages: 75-79
• DOI: https://doi.org/10.1016/j.hest.2019.12.001
• Public URL: https://nottingham-repository.worktribe.com/output/3794398
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2589238X20300012