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On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children (2022)
Journal Article
Feys, O., Corvilain, P., Aeby, A., Sculier, C., Holmes, N., Brookes, M., Goldman, S., Wens, V., & De Tiège, X. (2022). On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children. Radiology, 304(2), 429-434. https://doi.org/10.1148/radiol.212453

Background Magnetoencephalography (MEG) is an established method used to detect and localize focal interictal epileptiform discharges (IEDs). Current MEG systems house hundreds of cryogenic sensors in a rigid, one-size-fits-all helmet, which results... Read More about On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children.

Using OPM-MEG in contrasting magnetic environments (2022)
Journal Article
Hill, R. M., Devasagayam, J., Holmes, N., Boto, E., Shah, V., Osborne, J., Safar, K., Worcester, F., Mariani, C., Dawson, E., Woolger, D., Bowtell, R., Taylor, M. J., & Brookes, M. J. (2022). Using OPM-MEG in contrasting magnetic environments. NeuroImage, 253, Article 119084. https://doi.org/10.1016/j.neuroimage.2022.119084

Magnetoencephalography (MEG) has been revolutionised by optically pumped magnetometers (OPMs). “OPM-MEG” offers higher sensitivity, better spatial resolution, and lower cost than conventional instrumentation based on superconducting quantum interfere... Read More about Using OPM-MEG in contrasting magnetic environments.

Magnetic field design in a cylindrical high-permeability shield: The combination of simple building blocks and a genetic algorithm (2022)
Journal Article
Packer, M., Hobson, P. J., Davis, A., Holmes, N., Leggett, J., Glover, P., Hardwicke, N. L., Brookes, M. J., Bowtell, R., & Fromhold, T. M. (2022). Magnetic field design in a cylindrical high-permeability shield: The combination of simple building blocks and a genetic algorithm. Journal of Applied Physics, 131(9), Article 093902. https://doi.org/10.1063/5.0071986

Magnetically sensitive experiments and newly developed quantum technologies with integrated high-permeability magnetic shields require increasing control of their magnetic field environment and reductions in size, weight, power, and cost. However, ma... Read More about Magnetic field design in a cylindrical high-permeability shield: The combination of simple building blocks and a genetic algorithm.

Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children (2022)
Journal Article
Boto, E., Shah, V., Hill, R. M., Rhodes, N., Osborne, J., Doyle, C., Holmes, N., Rea, M., Leggett, J., Bowtell, R., & Brookes, M. J. (2022). Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children. NeuroImage, 252, Article 119027. https://doi.org/10.1016/j.neuroimage.2022.119027

Optically-pumped magnetometers (OPMs) are an established alternative to superconducting sensors for magnetoencephalography (MEG), offering significant advantages including flexibility to accommodate any head size, uniform coverage, free movement duri... Read More about Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children.

Optimised hybrid shielding and magnetic field control for emerging quantum technologies (2021)
Presentation / Conference Contribution
Hobson, P. J., Packer, M., Holmes, N., Davis, A., Patel, P., Holmes, D., Harrison, R., Chalmers, J., Styles, B., Woolger, D., Sims, D., Brookes, M. J., & Fromhold, T. M. (2021, September). Optimised hybrid shielding and magnetic field control for emerging quantum technologies. Presented at SPIE PHOTONEX, Glasgow, United Kingdom

The accurate control of magnetic fields is a cornerstone of multiple emerging quantum technologies. These technologies often require passive high permeability magnetic shielding and internal active field-generating coils to create their own bespoke m... Read More about Optimised hybrid shielding and magnetic field control for emerging quantum technologies.

Practical real-time MEG-based neural interfacing with optically pumped magnetometers (2021)
Journal Article
Wittevrongel, B., Holmes, N., Boto, E., Hill, R., Rea, M., Libert, A., Khachatryan, E., Van Hulle, M. M., Bowtell, R., & Brookes, M. J. (2021). Practical real-time MEG-based neural interfacing with optically pumped magnetometers. BMC Biology, 19(1), Article 158. https://doi.org/10.1186/s12915-021-01073-6

Background: Brain-computer interfaces decode intentions directly from the human brain with the aim to restore lost functionality, control external devices or augment daily experiences. To combine optimal performance with wide applicability, high-qual... Read More about Practical real-time MEG-based neural interfacing with optically pumped magnetometers.

Magnetic Field Mapping and Correction for Moving OP-MEG (2021)
Journal Article
Mellor, S., Tierney, T. M., O'Neill, G. C., Alexander, N., Seymour, R. A., Holmes, N., Lopez, J. D., Hill, R. M., Boto, E., Rea, M., Roberts, G., Leggett, J., Bowtell, R., Brookes, M. J., Maguire, E. A., Walker, M. C., & Barnes, G. R. (2022). Magnetic Field Mapping and Correction for Moving OP-MEG. IEEE Transactions on Biomedical Engineering, 69(2), 528-536. https://doi.org/10.1109/TBME.2021.3100770

Background: Optically pumped magnetometers (OPMs) have made moving, wearable magnetoencephalography (MEG) possible. The OPMs typically used for MEG require a low background magnetic field to operate, which is achieved using both passive and active ma... Read More about Magnetic Field Mapping and Correction for Moving OP-MEG.

Precision magnetic field modelling and control for wearable magnetoencephalography (2021)
Journal Article
Rea, M., Holmes, N., Hill, R. M., Boto, E., Leggett, J., Edwards, L. J., David 4 Woolger, Dawson, E., Shah, V., Osborne, J., Bowtell, R., & Brookes, M. J. (2021). Precision magnetic field modelling and control for wearable magnetoencephalography. NeuroImage, 241, Article 118401. https://doi.org/10.1016/j.neuroimage.2021.118401

Optically-pumped magnetometers (OPMs) are highly sensitive, compact magnetic field sensors, which offer a viable alternative to cryogenic sensors (superconducting quantum interference devices – SQUIDs) for magnetoencephalography (MEG). With the promi... Read More about Precision magnetic field modelling and control for wearable magnetoencephalography.

Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system (2021)
Journal Article
Brookes, M. J., Boto, E., Rea, M., Shah, V., Osborne, J., Holmes, N., Hill, R. M., Leggett, J., Rhodes, N., & Bowtell, R. (2021). Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system. NeuroImage, 236, Article 118025. https://doi.org/10.1016/j.neuroimage.2021.118025

The optically pumped magnetometer (OPM) is a viable means to detect magnetic fields generated by human brain activity. Compared to conventional detectors (superconducting quantum interference devices) OPMs are small, lightweight, flexible, and operat... Read More about Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system.

Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder (2020)
Journal Article
Packer, M., Hobson, P., Holmes, N., Leggett, J., Glover, P., Brookes, M., Bowtell, R., & Fromhold, T. (2020). Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder. Physical Review Applied, 14(5), Article 054004. https://doi.org/10.1103/PhysRevApplied.14.054004

Magnetic shields that use both active and passive components to enable the generation of a tailored low-field environment are required for many applications in science, engineering, and medical imaging. Until now, accurate field nulling, or field gen... Read More about Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder.

Mouth magnetoencephalography: A unique perspective on the human hippocampus (2020)
Journal Article
Tierney, T. M., Levy, A., Barry, D. N., Meyer, S. S., Shigihara, Y., Everatt, M., Mellor, S., Lopez, J. D., Bestmann, S., Holmes, N., Roberts, G., Hill, R. M., Boto, E., Leggett, J., Shah, V., Brookes, M. J., Bowtell, R., Maguire, E. A., & Barnes, G. R. (2021). Mouth magnetoencephalography: A unique perspective on the human hippocampus. NeuroImage, 225, Article 117443. https://doi.org/10.1016/j.neuroimage.2020.117443

Traditional magnetoencephalographic (MEG) brain imaging scanners consist of a rigid sensor array surrounding the head; this means that they are maximally sensitive to superficial brain structures. New technology based on optical pumping means that we... Read More about Mouth magnetoencephalography: A unique perspective on the human hippocampus.

Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system (2020)
Journal Article
Hill, R. M., Boto, E., Rea, M., Holmes, N., Leggett, J., Coles, L. A., Papastavrou, M., Everton, S., Hunt, B. A., Sims, D., Osborne, J., Shah, V., Bowtell, R., & Brookes, M. J. (2020). Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system. NeuroImage, 219, Article 116995. https://doi.org/10.1016/j.neuroimage.2020.116995

© 2020 The Authors Magnetoencephalography (MEG) is a powerful technique for functional neuroimaging, offering a non-invasive window on brain electrophysiology. MEG systems have traditionally been based on cryogenic sensors which detect the small extr... Read More about Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system.